Raman spectroscopy – Basic principle, instrumentation and selected applications for the characterization of drugs of abuse

Bumbrah, Gurvinder Singh; Sharma, Rakesh Mohan

doi:10.1016/j.ejfs.2015.06.001

Cited by 198 publications

(131 citation statements)

References 31 publications

Supporting

Mentioning

130

Contrasting

Unclassified

Order By: Relevance

“…However, this overlap can increase the Raman intensities and decrease the detection limits, but a significant fluorescence background is revealed. This background can be very stronger than the Raman signals, but using the prepared substrates, significant enhancement of SERS will be achieved (ISERS ∝ E 4 while Iemission ∝ E 2 ) and simultaneously the fluorescence quenching occurred [18].…”

Section: A Uv-vis Absorption and Fluorescence Emission Spectra Analysismentioning

confidence: 99%

Surface Enhanced Raman Scattering of Crystal Violet with Low Concentrations Using Self-Assembled Silver and Gold-Silver Core-Shell Nanoparticles

Morovvati

Malekfar

2019

IJOP

View full text Add to dashboard Cite

The active substrates in surface enhancedRaman scattering (SERS) spectroscopy were prepared through selfassembly of nanoparticles on functionalized glasses. Colloidal silver nanoparticles (Ag NPs) were prepared chemically in two different sizes by reduction of AgNO3 using trisodium citrate and sodium borohydride. Gold-silver core-shell nanoparticles were also prepared to compare between the optical behaviors of their silver shell and Ag NPs. Absorption spectra of nanoparticles were measured by ultravioletvisible (UV-Vis.) spectroscopy, and their approximate sizes were determined by dynamic light scattering (DLS). The core-shell nanoparticles were approximately the same size as the largest Ag NPs (35 nm) and had the same maximum absorption wavelength. The potential of these substrates for detection applications was investigated with 1 M and 0.1 mM solutions of Raman-active molecule of crystal violet (CV) dye. The Raman enhancement signal was recorded for 0.1 mM solution with 532 nm laser wavelength, and the obtained spectra enhancement factor (EF) was calculated. EF values indicated that although the silver and gold-silver core-shell nanoparticles had the same surface plasmon resonance, the substrate with smaller Ag NPs had the highest enhancement factor compared to other substrates, which was 9.510 3 , and the coreshell substrate even had a slightly lower enhancement factor in compare with the large Ag NPs.

show abstract

Section: A Uv-vis Absorption and Fluorescence Emission Spectra Analysismentioning

confidence: 99%

Surface Enhanced Raman Scattering of Crystal Violet with Low Concentrations Using Self-Assembled Silver and Gold-Silver Core-Shell Nanoparticles

Morovvati

Malekfar

2019

IJOP

View full text Add to dashboard Cite

show abstract

“…The difference frequency of incident radiation and the intensity of the dispersion signals originates Stokes and anti-Stokes lines, as shown in Figure 1. These phenomena define the basic principle for the variants presented in Table 1 (5,9). The instrumental versatility of Raman spectroscopy includes interferometric dispersive systems, single channel multichannel detection systems, and microscope coupled systems (Table 1).…”

Section: Main Variants Of Raman Spectroscopymentioning

confidence: 99%

“…Each photon occurs in a different vibrational mode, and this frequency difference refers to the separation of the vibrational energy level of the molecules. The dispersion signals origins from the inelastic movement between the incident monochromatic radiation and vibrational molecular motions, providing a unique signature for each substance (1,(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Raman Spectroscopy for Quantitative Analysis in the Pharmaceutical Industry

2020

View full text Add to dashboard Cite

Raman spectroscopy is a very promising technique increasingly used in the pharmaceutical industry. Due to its development and improved instrumental versatility achieved over recent decades and through the application of chemometric methods, this technique has become highly precise and sensitive for the quantification of drug substances. Thus, it has become fundamental in identifying critical variables and their clinical relevance in the development of new drugs. In process monitoring, it has been used to highlight in-line real-time analysis, and it has been used more commonly since 2004 when the Food and Drug Administration (FDA) launched Process Analytical Technology (PAT), integrated with the concepts of Pharmaceutical Current Good Manufacturing Practices (CGMPs) for the 21st Century. The present review presents advances in the application of this tool in the development of pharmaceutical products and processes in the last six years.

show abstract

“…Raman spectroscopy is scattering spectroscopy (Bumbrah & Sharma, ; Chalmers, Edwards, & Hargreaves, ; Shea, ). As the chemical composition and molecular structure of a sample can be reflected at molecular levels, the positions of Raman bands can directly reflect the energy of the chemical bond vibrations.…”

Section: Principles Of Hmimentioning

confidence: 99%

Principles of Hyperspectral Microscope Imaging Techniques and Their Applications in Food Quality and Safety Detection: A Review

Sun

2019

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

Hyperspectral imaging (HSI) techniques play an important role in the food industry for providing rapid, nondestructive, and chemical‐free detection method, whereas a microscope can provide detailed information about the microstructure of a food item. As an emerging imaging spectroscopy technique, hyperspectral microscope imaging (HMI) technique combines the advantages of HSI with microscopic imaging and has been gradually applied in the food industry. This review introduces the principles of different kinds of HMI techniques, such as fluorescence HMI, visible/near‐infrared HMI, Raman HMI, and infrared HMI. Moreover, detailed applications of HMI techniques are summarized, including evaluation of structures of nutrients, and detection of microorganisms and residues. On the other hand, some challenges and future trends in the applications of these techniques are also discussed. It is concluded that by integrating HSI with microscopy, HMI can not only provide both spectral and spatial information about food substances but also provide their chemical information at the molecular or cellular level. Therefore, HMI techniques have great potentials in nondestructive evaluation of structures of nutrients, and detection of microorganisms and residues for the food industry.

show abstract

Raman spectroscopy – Basic principle, instrumentation and selected applications for the characterization of drugs of abuse

Cited by 198 publications

References 31 publications

Surface Enhanced Raman Scattering of Crystal Violet with Low Concentrations Using Self-Assembled Silver and Gold-Silver Core-Shell Nanoparticles

Surface Enhanced Raman Scattering of Crystal Violet with Low Concentrations Using Self-Assembled Silver and Gold-Silver Core-Shell Nanoparticles

Raman Spectroscopy for Quantitative Analysis in the Pharmaceutical Industry

Principles of Hyperspectral Microscope Imaging Techniques and Their Applications in Food Quality and Safety Detection: A Review

Contact Info

Product

Resources

About