Raman spectroscopy based analysis inside photonic-crystal fibers

Маркин, А. В.; Markina, Natalia E.; Goryacheva, Irina Yu.

doi:10.1016/j.trac.2017.01.003

Cited by 29 publications

(13 citation statements)

References 78 publications

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“…FERS based on HC-PCFs was further exploited in combination with SERS [107]. Yet, it remains to be proven whether these approaches will be practicable for drug monitoring.…”

Section: Fiber-enhanced Raman Spectroscopy For Drug Monitoringmentioning

confidence: 99%

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Recent advances in nano-photonic techniques for pharmaceutical drug monitoring with emphasis on Raman spectroscopy

Knebl

Frosch

2019

Nanophotonics

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Innovations in Raman spectroscopic techniques provide a potential solution to current problems in pharmaceutical drug monitoring. This review aims to summarize the recent advances in the field. The developments of novel plasmonic nanoparticles continuously push the limits of Raman spectroscopic detection. In surface-enhanced Raman spectroscopy (SERS), these particles are used for the strong local enhancement of Raman signals from pharmaceutical drugs. SERS is increasingly applied for forensic trace detection and for therapeutic drug monitoring. In combination with spatially offset Raman spectroscopy, further application fields could be addressed, e.g. in situ pharmaceutical quality testing through the packaging. Raman optical activity, which enables the thorough analysis of specific chiral properties of drugs, can also be combined with SERS for signal enhancement. Besides SERS, micro- and nano-structured optical hollow fibers enable a versatile approach for Raman signal enhancement of pharmaceuticals. Within the fiber, the volume of interaction between drug molecules and laser light is increased compared with conventional methods. Advances in fiber-enhanced Raman spectroscopy point at the high potential for continuous online drug monitoring in clinical therapeutic diagnosis. Furthermore, fiber-array based non-invasive Raman spectroscopic chemical imaging of tablets might find application in the detection of substandard and counterfeit drugs. The discussed techniques are promising and might soon find widespread application for the detection and monitoring of drugs in various fields.

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“…FERS based on HC-PCFs was further exploited in combination with SERS [107]. Yet, it remains to be proven whether these approaches will be practicable for drug monitoring.…”

Section: Fiber-enhanced Raman Spectroscopy For Drug Monitoringmentioning

confidence: 99%

“…Adapted from Frosch et al [47], reproduced with the kind permission of the American Chemical Society, Copyright (2013) American Chemical Society. for the detection of model substances, biomarkers, or cells for biomedical applications but not yet for approved pharmaceuticals [107].…”

Section: Fiber-enhanced Raman Spectroscopy For Drug Monitoringmentioning

confidence: 99%

Recent advances in nano-photonic techniques for pharmaceutical drug monitoring with emphasis on Raman spectroscopy

Knebl

Frosch

2019

Nanophotonics

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“…The Raman intensity I stokes can be increased by increasing the excitation frequency ω 0 , the laser power I 0 , or the number of molecules N, which contribute to the Raman signal [38]. The last approach is exploited in fiber-enhanced Raman spectroscopy (FERS), where the light is guided in the hollow fiber [38][39][40][41][42][43][44][45][46][47][48] and can strongly interact with the drug molecules over an extended interaction length [49][50][51][52][53][54] (Figure 1). Within the last decades, a lot of effort was invested in studying the fiber enhancement effect of photonic crystal fibers [55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70][71][72][73].…”

Section: Introductionmentioning

confidence: 99%

Highly Sensitive Detection of the Antibiotic Ciprofloxacin by Means of Fiber Enhanced Raman Spectroscopy

et al. 2019

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Sepsis and septic shock exhibit a rapid course and a high fatality rate. Antibiotic treatment is time-critical and precise knowledge of the antibiotic concentration during the patients’ treatment would allow individual dose adaption. Over- and underdosing will increase the antimicrobial efficacy and reduce toxicity. We demonstrated that fiber enhanced Raman spectroscopy (FERS) can be used to detect very low concentrations of ciprofloxacin in clinically relevant doses, down to 1.5 µM. Fiber enhancement was achieved in bandgap shifted photonic crystal fibers. The high linearity between the Raman signals and the drug concentrations allows a robust calibration for drug quantification. The needed sample volume was very low (0.58 µL) and an acquisition time of 30 s allowed the rapid monitoring of ciprofloxacin levels in a less invasive way than conventional techniques. These results demonstrate that FERS has a high potential for clinical in-situ monitoring of ciprofloxacin levels.

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“…Photochemical approach has been used to synthesize Ag nanostructures suspended in solution by directly exposing on growth solution 19,24–26 . Recently, several studies combining SERS activity with optical fibre for directional development SERS optical fibre probe of biochemical compact optical fibre sensors using in outdoor fields have been recognized 27–29 . Ag nanoparticles have been modified on the silanized surface which was created by functionalizing SERS optical fibre probe 30–32 or the Ag nanoparticles have been synthesized on the fiber taper surface through chemical deposition method 33 .…”

Section: Introductionmentioning

confidence: 99%

Detection of Permethrin pesticide using silver nano-dendrites SERS on optical fibre fabricated by laser-assisted photochemical method

Pham

Hoang

Hai

et al. 2019

Sci Rep

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Permethrin, 3-Phenoxybenzyl (1 RS)-cis,trans-3-(2,2-dichlorovinyl)- 2,2-dimethylcyclopropanecarboxylate, has a wide range of applications like insecticide, insect repellent and prevents mosquito-borne diseases, such as dengue fever and malaria in tropical areas. In this work, we develop a prominent monitoring method for the detection of permethrin pesticide using surface-enhanced Raman scattering (SERS) optical fibre substrates. The novel SERS-active optical fibre substrates were grown and deposited silver (Ag) nano-dendrites on the end of multi-mode fibre core by laser-assisted photochemical method. The characteristic of the Ag-nanostructures could be controlled by the experimental conditions, namely, laser illumination time. Ag nanoparticles optical fibre substrates and Ag nano-dendrites optical fibre substrates were prepared with laser illumination time of 3 min and 8 min, respectively. The achieved SERS-activity optical fibre substrates were tested with Rhodamine 6G aqueous solutions. We demonstrate that the SERS activity coupled with Ag nano-dendrites optical fibre substrate has higher Raman enhancement factor due to the creation of many of hot-spots for amplifying Raman signals. Besides, the stability and reproducibility of the Ag nano-dendrites optical fibre substrate were also evaluated with stored time of 1000 hours and relative standard deviation of less than 3%. The Ag nano-dendrite optical fibre substrate was selected for detection of permethrin pesticide in the concentration range of 0.1 ppm–20 ppm with limit of quantification (LOQ) of 0.1 ppm and calculated limit of detection (LOD) of 0.0035 ppm, proving its great potential for direct, rapid detection and monitoring of permethrin.

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Raman spectroscopy based analysis inside photonic-crystal fibers

Cited by 29 publications

References 78 publications

Recent advances in nano-photonic techniques for pharmaceutical drug monitoring with emphasis on Raman spectroscopy

Recent advances in nano-photonic techniques for pharmaceutical drug monitoring with emphasis on Raman spectroscopy

Highly Sensitive Detection of the Antibiotic Ciprofloxacin by Means of Fiber Enhanced Raman Spectroscopy

Detection of Permethrin pesticide using silver nano-dendrites SERS on optical fibre fabricated by laser-assisted photochemical method

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