Raman spectroscopy and U‐Net deep neural network in antiresorptive drug‐related osteonecrosis of the jaw
Levi Matthies,
Medhanie T. Gebrekidan,
Andreas S. Braeuer
et al.
Abstract:ObjectiveApplication of an optical method for the identification of antiresorptive drug‐related osteonecrosis of the jaw (ARONJ).MethodsWe introduce shifted‐excitation Raman difference spectroscopy followed by U‐Net deep neural network refinement to determine bone tissue viability. The obtained results are validated through established histological methods.ResultsDiscrimination of osteonecrosis from physiological tissues was evaluated at 119 distinct measurement loci in 40 surgical specimens from 28 patients. … Show more
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