Raman spectrometer for the automated scan of large painted surfaces

Mencaglia, A. A.; Osticioli, Iacopo; Ciofini, Daniele; Gallo, L.R.

doi:10.1063/1.5088039

Cited by 10 publications

(6 citation statements)

References 41 publications

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“…Miniaturized Raman spectroscopy systems have been demonstrated to have excellent or lab-equivalent performance 35 and optimizing these systems for SARS-CoV-2 detection might be feasible. For mass screening purposes, multisample trays could be introduced and a digital micromirror device 36 or a laser scanner 37 might be used for rapid Raman probing and identification of the virus among many clinical samples.…”

Section: Discussionmentioning

confidence: 99%

Machine learning detects SARS-CoV-2 and variants rapidly on DNA aptamer metasurfaces

Torun

Bilgin

İlgü

et al. 2021

Preprint

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COVID-19 is detected using reverse transcription polymerase chain reaction (RT-PCR) of nasal swabs. A very sensitive and rapid detection technique using easily-collected fluids like saliva must be developed for safe and precise mass testing. Here, we introduce a metasurface platform for direct sensing of COVID-19 from unprocessed saliva. We computationally screen gold metasurfaces out of a pattern space of 2100 combinations for strongly-enhanced light-virus interaction with machine learning and use it to investigate the presence and concentration of the SARS-CoV-2. We use machine learning to identify the virus from Raman spectra with 95.2% sensitivity and specificity on 36 PCR positive and 33 negative clinical samples and to distinguish wild-type, alpha, and beta variants. Our results could pave the way for effective, safe and quantitative preventive screening and identification of variants.

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Section: Discussionmentioning

confidence: 99%

Machine learning detects SARS-CoV-2 and variants rapidly on DNA aptamer metasurfaces

Torun

Bilgin

İlgü

et al. 2021

Preprint

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“…Raman system was extensively described in references [5,6,16]. Briefly, the laser source (1064 nm) coupled with an optical fibre produced the beam excitation, which was focused on the sample through an aspheric lens.…”

Section: Raman Systemmentioning

confidence: 99%

Development of a novel probe for measuring emissivity and temperature during Raman spectroscopy

Calvagna

Mencaglia

Osticioli

et al. 2022

J. Phys.: Conf. Ser.

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In this work, an innovative tool to perform real-time measurements of emissivity and temperature of a given material surface under CW laser irradiation was developed. In the radiative energy balance, the emissivity represents the complementary component of the reflectance, thus, its measurement can be exploited to calculate the temperature at the target surface from infrared emission measurements provided by a suitable sensor. A miniaturized photothermal sensing line was designed as an accessory of Raman probes for driving thermal control loops in order to prevent overheating during the spectroscopic acquisition. To demonstrate its effectiveness and reliability, it was integrated with in a home-made Raman instrument (exc. 1064 nm) and associated software to achieve an automated online thermal control. Temperature rise during Raman spectroscopy can induce chemical alterations of the material under analysis and seriously affect its original spectral features. In several applications, such photothermal side effects can represent a serious problem to be carefully controlled in order to safeguard the integrity of the material and its spectral fingerprint. A thorough experimentation of the novel tool was carried out on photothermally sensitive materials such as red lead and massicot powders, traditionally used as pigments since ancient times. Finally, the compactness of the components and the fast response time made this system particularly suitable for nondestructive in-situ investigations.

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“…Lauwers et al [ 150 ] reported the applicability of a commercial fibre‐optics Raman spectrometer combined to stepper motors to perform Raman mappings and aimed towards the implementation of the appropriate post‐treatment tools for creating molecular images. Mencaglia et al [ 151 ] created a Raman scanner, applicable for on‐field applications equipped with a 1064‐nm laser and a sensor monitoring the temperature.…”

Section: Developmentsmentioning

confidence: 99%

In situ Raman spectroscopy for cultural heritage studies

Rousaki

Vandenabeele

2021

J Raman Spectroscopy

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Raman spectroscopy is considered as one of the most appreciated analytical techniques in the cultural heritage research field, thanks to some of its favourable characteristics such as the relatively quick time of analysis, identification of both inorganic and organic molecules. The necessity of conducting the research non-destructively on-site and directly on the artefact brought the technique out of the laboratory. Since 2004, when the first non-commercial mobile Raman instrument for in situ applications on cultural heritage objects was realized, years of continuous technical and instrumental developments have passed. Today, on-site Raman spectroscopy is considered as a cornerstone technique for the documentation of materials of works of art and the assessment of their conservation state without jeopardizing the integrity of the artefact. This paper reviews some of the breakthroughs of Raman analysis of cultural heritage objects, conducted on field (museum environment, outdoors and archaeological complexes).

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Raman spectrometer for the automated scan of large painted surfaces

Cited by 10 publications

References 41 publications

Machine learning detects SARS-CoV-2 and variants rapidly on DNA aptamer metasurfaces

Machine learning detects SARS-CoV-2 and variants rapidly on DNA aptamer metasurfaces

Development of a novel probe for measuring emissivity and temperature during Raman spectroscopy

In situ Raman spectroscopy for cultural heritage studies

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