Raman scattering of Cisplatin near silver nanoparticles

Surface-enhanced raman scattering nanostructures potential for biomedical applications

“…33 With the aid of the computer control of the size of the unit and the distance of intergaps precisely, effective SERS-active substrates from Au NPs and Aunanohole arrays were effectively achieved. Figure 1 shows different Aunanohole arrays with various diameters of units and the distances of intergaps and Table 1 lists the relevant nanoholearrays dimensions for comparison, where D: unit diameters, S: intergap distances, N surface is the number of 4-MBAmolecules adsorbed on the SERS-active area where the laser spot is irradiated, and EF: EF=I surface N solution /I solution N surface .I surface and I solution are 1077 cm -1 band intensities from the NP and nanohole array substrate and solution sample, respectively.N solution is defined as the number of 4-mercaptobenzoic acid (4-MBA) molecules irradiated with the spot of laser, calculated as 5.34×10 8 with 78.5 µm 2 of the size area of a laser spot and a packing density of 6.8×10 14 4-MBA molecules/cm 2 . Meanwhile, 4-MBA was taken as probe molecules, and self-assembled on Aunanoarrays to generate SERS spectra for the calculation of the enhancement to sure the influence of the size of the unit and the distance of the intergapson the SERS signals from various arrays.…”

“…The dielectric constant of the metal, determined the frequency of the surface plasma resonance, is the key to the SERS effects detected from only a few metals such as alkali metals, Au, Ag, and Cu. [12][13][14][15][16] With the mechanism of SERS extensive exploring, SERS have an effective nanoscale effects in the field of nanoscience. When the nanostructures are agglomerated or distributed uniformly, the relevant intensity of SERS will be significantly decreased, for example, nanoparticles, nanorods, nanobranches and nano wires as the size of the constructed structures is much smaller than 10 nm or much larger than 100 nm.…”

Remarkably Intricate Raman Spectra of Platinum(II)–Ligand Skeletal Modes in Diamminedihalido Complexes

“…Many properties of cis -diamminedichloridoplatinum­(II) ( cis -[Pt­(NH 3 ) 2 Cl 2 ], cisplatin) have been studied in detail over the past half century due to its immense therapeutic importance. , Vibrational spectroscopy has long provided crucial quantitative information on this key compound, starting with pioneering infrared spectra by Poulet and Nakamoto up to modern surface-enhanced Raman spectroscopy and silver-nanoparticle enhanced Raman spectra, inelastic neutron scattering, , as well as in situ and gas-phase studies using ammonia modes as sensitive structural probes. − Good vibrational spectra, along with precise solid-state structures, are the most important experimental quantities directly comparable to computational results. Numerous electronic structure calculations presenting optimized structures, vibrational frequencies, and sometimes also infrared and Raman spectra of cisplatin have been published over the past 25 years. ,− Such calculations are an important starting point for modeling the behavior of cisplatin in cells. , Detailed crystal structures of cis -[Pt­(NH 3 ) 2 Cl 2 ] at variable temperature have been published, allowing the comparison with calculated structures.…”

“…Many properties of cis-diamminedichloridoplatinum(II) (cis-[Pt(NH 3 ) 2 Cl 2 ], cisplatin) have been studied in detail over the past half century due to its immense therapeutic importance. 1,2 Vibrational spectroscopy has long provided crucial quantitative information on this key compound, starting with pioneering infrared spectra by Poulet 3 and Nakamoto 4 up to modern surface-enhanced Raman spectroscopy and silver-nanoparticle enhanced Raman spectra, 5 inelastic neutron scattering, 6,7 as well as in situ and gas-phase studies using ammonia modes as sensitive structural probes. 8−12 Good vibrational spectra, along with precise solid-state structures, are the most important experimental quantities directly comparable to computational results.…”