Raman probes based on optically-poled double-clad fiber and coupler

Brunetti, Anna Chiara; Margulis, Walter; Rottwitt, Karsten

doi:10.1364/oe.20.028563

Cited by 5 publications

(5 citation statements)

References 33 publications

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“…The 532 nm Raman excitation light has traveled through only a portion of the fiber and thereby generated less contaminating signal [434]. The Morris group avoided the glass problem by using a fluorocarbon probe.…”

Section: Challengesmentioning

confidence: 99%

Raman spectroscopy: techniques and applications in the life sciences

Shipp¹,

Sinjab²,

Notingher³

2017

Adv. Opt. Photon.

255

189

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Raman spectroscopy is an increasingly popular technique in many areas including biology and medicine.It is based on Raman scattering, a phenomenon in which incident photons lose or gain energy via interactions with vibrating molecules in a sample. These energy shifts can be used to obtain information regarding molecular composition of the sample with very high accuracy. Applications of Raman spectroscopy in the life sciences have included quantification of biomolecules, hyperspectral molecular imaging of cells and tissue, medical diagnosis, and others. This review briefly presents the physical origin of Raman scattering explaining the key classical and quantum mechanical concepts. Variations of the Raman effect will also be considered, including resonance, coherent, and enhanced Raman scattering. We discuss the molecular origins of prominent bands often found in the Raman spectra of biological samples. Finally, we examine several variations of Raman spectroscopy techniques in practice, looking at their applications, strengths, and challenges. This review is intended to be a starting resource for scientists new to Raman spectroscopy, providing theoretical background and practical examples as the foundation for further study and exploration.

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Section: Challengesmentioning

confidence: 99%

Raman spectroscopy: techniques and applications in the life sciences

Shipp¹,

Sinjab²,

Notingher³

2017

Adv. Opt. Photon.

255

189

View full text Add to dashboard Cite

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“…1(a). Laser light propagates in the core of a double-clad fibre 34, 35 (DCF) to the micro-chamber and excites the fluorescent particles or cells delivered by the Input capillary one at a time. Particles are focused into a single stream at the centre of the input capillary by using Elasto-inertial microfluidics.…”

Section: Resultsmentioning

confidence: 99%

“…The DCF transmits the excitation light in the core to the micro-chamber and the collected emission and scattering in the inner cladding to the detection system. The light travelling in the inner cladding of the DCF is coupled out to a multimode fibre (MMF) with an efficiency ~50% using a home-made proximity coupler 34 (DCF coupler, (A) in Fig. 5).…”

Section: Methodsmentioning

confidence: 99%

“…Light is delivered to the micro-chamber through an optical fibre. Fluorescence and scattered light is collected with the same fibre, whereby the cells can be identified 34 . In contrast to previous work, stable single-stream focusing in PEO fluids is achieved at high Reynolds numbers and high flow rates, enabling accurate high-throughput cytometry.…”

Section: Introductionmentioning

confidence: 99%

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High performance micro-flow cytometer based on optical fibres

Etcheverry

Faridi

Ramachandraiah

et al. 2017

Sci Rep

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Flow cytometry is currently the gold standard for analysis of cells in the medical laboratory and biomedical research. Fuelled by the need of point-of-care diagnosis, a significant effort has been made to miniaturize and reduce cost of flow cytometers. However, despite recent advances, current microsystems remain less versatile and much slower than their large-scale counterparts. In this work, an all-silica fibre microflow cytometer is presented that measures fluorescence and scattering from particles and cells. It integrates cell transport in circular capillaries and light delivery by optical fibres. Single-stream cell focusing is performed by Elasto-inertial microfluidics to guarantee accurate and sensitive detection. The capability of this technique is extended to high flow rates (up to 800 µl/min), enabling a throughput of 2500 particles/s. The robust, portable and low-cost system described here could be the basis for a point-of-care flow cytometer with a performance comparable to commercial systems.

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“…This paper shows that DCFs can increase the pointing accuracy tolerance while improving the received power *sarah.a.tedder@nasa.gov; phone 1 216 433-6591; nasa.gov Power Meter stability. This is because a DCF can transmit through a single mode fiber core and receive light through a multimode cladding within the same cable and using the same optical axis 5 . This paper will compare measured pointing accuracy tolerance and received power stability of DCFs to single mode and multimode fibers in a 20 meter free space optical link.…”

Section: Introductionmentioning

confidence: 99%

Exploration of double clad fibers for increased stability of bidirectional free space optical links

Tedder

Schoenholz

Berkson

et al. 2018

Free-Space Laser Communication and Atmospheric Propagation XXX

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Bidirectional, high data rate, low size, weight, and power (SWaP), and low cost free space optical links are needed for space and aeronautic communication applications to send and receive large volumes of data. We are exploring design strategies for optical transceivers to reduce SWaP and cost through increased misalignment tolerance (pointing requirement reduction) and sharing the optical transmit and receive paths (imposing optical symmetry). In applications where the detector is fiber coupled, the receive fiber numerical aperture is the main driver of the pointing accuracy requirement. Increasing the numerical aperture of the receive fiber reduces the pointing requirement. In an optically symmetric design, the fibers both transmit and receive the light. Hence, increasing the receive fiber numerical aperture requires a similar increase of the transmit fiber. Unfortunately, increasing the transmit fiber numerical aperture causes instability in received power over small misalignments. Double clad fibers offer a solution. These fibers transmit from a single mode core and receive light in a larger numerical aperture. Results show that as transceiver fibers, double clad fibers have an improved misalignment tolerance and a higher stability for small changes in misalignment when compared to single mode fibers and multimode fibers. Also, double clad fibers are shown to match the performance of an asymmetrical link design with a single mode transmit fiber and a multimode receive fiber.

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Raman probes based on optically-poled double-clad fiber and coupler

Cited by 5 publications

References 33 publications

Raman spectroscopy: techniques and applications in the life sciences

Raman spectroscopy: techniques and applications in the life sciences

High performance micro-flow cytometer based on optical fibres

Exploration of double clad fibers for increased stability of bidirectional free space optical links

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