Raman opportunities in the field of pathological calcifications

Lucas, Ivan T.; Bazin, Dominique; Daudon, Michel

doi:10.5802/crchim.110

Cited by 13 publications

(7 citation statements)

References 192 publications

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“…Nevertheless, they both can be identified and investigated through FT-IR spectroscopy. ACCP was recently, reported in breast calcifications [98] and is observed alongside CA, as it is considered as its precursor. This association of ACCP and CA in BMCs is revealed by the presence of a shoulder at 1032 cm −1 in the phosphate absorption band [99].…”

Section: Ir Spectroscopy and Bmc Chemical Speciationmentioning

confidence: 97%

Multiscale approach to provide a better physicochemical description of women breast microcalcifications

Petay¹,

Cherfan²,

Bouderlique³

et al. 2022

Comptes Rendus. Chimie

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Despite the incidence of breast cancer among women, mammography and anatomopathology investigations are still the gold standard method for preventive screening and diagnosis. Several criteria are used to diagnose precisely the severity of the pathology like the distribution and shape of breast microcalcifications (BMCs). However, the link between the different chemical phases of BMCs and the cancer stage remains unclear. As BMCs physicochemical speciation has the potential to help clinicians during their diagnosis, this study aims to propose a methodology using advanced spectroscopical analysis techniques to finely characterize BMCs and uncover the relationship between

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Section: Ir Spectroscopy and Bmc Chemical Speciationmentioning

confidence: 97%

Multiscale approach to provide a better physicochemical description of women breast microcalcifications

Petay¹,

Cherfan²,

Bouderlique³

et al. 2022

Comptes Rendus. Chimie

Self Cite

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“…It also allowed us to determine the chemical phase in which some of the metals are engaged, such as Ti cations which can be present as anatase or rutile (Frank et al, 2012). Spectra were collected using a micro-Raman system (LabRam HR-800 Evolution, Horiba, Japan) with a 785 nm laser excitation wavelength, 100Â objective (Olympus, numerical aperture 0.9) and 300 grooves per mm grating (Lucas et al, 2022;Tamosaityte et al, 2021;Carden et al, 2003).…”

Section: Characterization Techniquesmentioning

confidence: 99%

“…We have also applied this methodology to skin (Colboc et al, 2016(Colboc et al, , 2019a(Colboc et al, ,b, 2020(Colboc et al, , 2022a as described below. Elemental composition and distribution of chemical elements can be determined using X-ray fluorescence (XRF) (Rouzie `re et al, 2016;Reguer et al, 2016), while chemical analyses are performed using a combination of Raman (Lucas et al, 2022) and X-ray absorption spectroscopy (mainly XANES, X-ray absorption near-edge structure) (Bazin et al, 2022a).…”

Section: Introductionmentioning

confidence: 99%

Chemical characterization of inks in skin reactions to tattoo

Colboc¹,

Bazin²,

Réguer³

et al. 2022

J Synchrotron Radiat

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Skin reactions are well described complications of tattooing, usually provoked by red inks. Chemical characterizations of these inks are usually based on limited subjects and techniques. This study aimed to determine the organic and inorganic composition of inks using X-ray fluorescence spectroscopy (XRF), X-ray absorption spectroscopy (XANES) and Raman spectroscopy, in a cohort of patients with cutaneous hypersensitivity reactions to tattoo. A retrospective multicenter study was performed, including 15 patients diagnosed with skin reactions to tattoos. Almost half of these patients developed skin reactions on black inks. XRF identified known allergenic metals – titanium, chromium, manganese, nickel and copper – in almost all cases. XANES spectroscopy distinguished zinc and iron present in ink from these elements in endogenous biomolecules. Raman spectroscopy showed the presence of both reported (azo pigments, quinacridone) and unreported (carbon black, phtalocyanine) putative organic sensitizer compounds, and also defined the phase in which Ti was engaged. To the best of the authors' knowledge, this paper reports the largest cohort of skin hypersensitivity reactions analyzed by multiple complementary techniques. With almost half the patients presenting skin reaction on black tattoo, the study suggests that black modern inks should also be considered to provoke skin reactions, probably because of the common association of carbon black with potential allergenic metals within these inks. Analysis of more skin reactions to tattoos is needed to identify the relevant chemical compounds and help render tattoo ink composition safer.

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“…Some of them are "classics" i.e. Raman and Infra-Red spectroscopies [136][137][138][139], Second Harmonic Generation (SHG), Scanning and Transmission Electron Microscopy (SEM and TEM) [80,[140][141][142], µX-ray fluorescence [143][144][145][146][147], µ X-ray diffraction [148][149][150][151][152][153] or Nuclear Magnetic Resonance (NMR) [154][155][156][157][158][159].…”

Section: Characterization By Physicochemical Techniquesmentioning

confidence: 99%

Foreword to microcrystalline pathologies: combining clinical activity and fundamental research at the nanoscale

Bazin¹,

Daudon²,

Frochot³

et al. 2022

Comptes Rendus. Chimie

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This contribution underlines the key role of physicochemical characterisation techniques in the area of medical research. The starting point centres on the Mid-InfraRed platform located at the Tenon hospital and dedicated to multidisciplinary functional investigations. In the last two decades, we have enhanced this platform by creating a network combining researchers from varied disciplines such as physicists, chemists, and clinicians. The resultant research dynamism is underscored by metrics such as 71 references in Pubmed and 129 in Web of Science, and the high impact of the journals in which we have published (New England Journal of Medicine, Kidney International, Chemical Review. . . ). It is of paramount importance to disseminate these physicochemical techniques among young doctors, and to establish collaborations with appropriate private companies.

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Raman opportunities in the field of pathological calcifications

Cited by 13 publications

References 192 publications

Multiscale approach to provide a better physicochemical description of women breast microcalcifications

Multiscale approach to provide a better physicochemical description of women breast microcalcifications

Chemical characterization of inks in skin reactions to tattoo

Foreword to microcrystalline pathologies: combining clinical activity and fundamental research at the nanoscale

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