Raman-on-chip device and detection fibres with fibre Bragg grating for analysis of solutions and particles

Dochow, Sebastian; Becker, Martin; Spittel, Ron; Beleites, Claudia; Stanca, Sarmiza Elena; Latka, Ines; Schuster, Kay; Kobelke, Jens; Unger, Sonja; Henkel, Thomas; Mayer, Günter; Albert, Jens; Rothhardt, Manfred; Krafft, Christoph; Popp, Jürgen

doi:10.1039/c2lc41169e

Cited by 31 publications

(21 citation statements)

References 16 publications

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“…Raman micro‐spectroscopy has been used for the identification of microorganism . It is now being considered a suitable detection probe with lab‐on‐chip to produce an efficient clinical diagnostic tool . Recently, it has been reported for the prediction of dengue virus infection and plasmodium viral infection in human sera/plasma .…”

Section: Introductionmentioning

confidence: 99%

Qualitative analysis of desi ghee, edible oils, and spreads using Raman spectroscopy

Ali

Nawaz

Saleem

et al. 2016

J. Raman Spectrosc.

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Keeping in view the importance of dietary fats in modulating disease risk, a study was planned to compare edible oils, spreads, and desi ghee based on fatty acid composition through Raman spectroscopy. The double bonds in unsaturated oils tend to react more with oxygen causing oxidative stress in living cells; therefore, the excessive use of processed vegetable oils may pose risk for human health. In the spectral analysis, Raman peaks at 1063 and 1127 cm−1 represent out‐of‐phase and in‐phase aliphatic CC stretch for saturated fatty acids. The peak at 1300 cm−1, labeled for alkane, decreases with increase in the double bond contents (unsaturation). Further, the Raman peak at 1655 cm−1 showed a monotonic increase as a function of unsaturation. The double bond contents in the Raman spectra from 1650–1657 cm−1 represent unsaturated fatty acids that changes during the synthesis of spreads and banaspati ghee. Desi ghee, extracted from cow and buffalo milk, showed distinctive Raman peaks at 1650 and 1655 cm−1, which originates because of isomers of conjugated linoleic acid. These Raman shifts differentiated desi ghee from other artificially produced banaspati ghee, spreads, and oils. Conjugated linoleic acid has proved to be anti‐carcinogenic, anti‐inflammatory, and anti‐allergic properties; therefore, the limited use of desi ghee may reduce the risk of cardiac diseases. Principal component analysis has been applied on the Raman spectra that clearly differentiated desi ghee, mono‐unsaturated extra virgin olive oil, and extra virgin olive oil spread from other oils, oil mixtures, spreads, and ghee. In addition, principal component analysis has been blindly applied successfully on 13 unknown samples to classify them with reference to the known ghee sample. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Introductionmentioning

confidence: 99%

Qualitative analysis of desi ghee, edible oils, and spreads using Raman spectroscopy

Ali

Nawaz

Saleem

et al. 2016

J. Raman Spectrosc.

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“…This approach is called Raman-on-chip (ROC) because fibers are used for excitation of Raman spectra, trapping of particles and collection of inelastically scattered light [12]. As no microscope is required the ROC approach is a promising platform for miniaturization and system integration.…”

Section: Raman Spectrum Of Tweezed Polystyrene Beadmentioning

confidence: 99%

Multi-core fiber with integrated fiber Bragg grating for background free Raman sensing

et al. 2013

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The combination of Raman spectroscopy with fiber optic probes enables analyzing the biochemical composition of tissues without markers in a non-destructive way. A small diameter (1 mm) fiber optic probe with one excitation fiber, 11 detection fibers and integrated filters (Emvision, USA) was recently coupled to a Raman spectrometer (Kaiser Optical Systems) to study excised arteries ex vivo and rabbit arteries in vivo. The current contribution introduces a novel fiber optic Raman probe with in-line fiber Bragg gratings (FBGs) as notch filter in the collection path. Multi-core single-mode fibers (MCSMF) were drawn integrating 19 and 61 single-mode cores to improve collection efficiency. Raman probes were assembled with one fiber for excitation and six MCSMF with inscribed FBGs for collection. The diameter of the 6 around 1 geometry can be reduced down to 0.375 mm. Background suppression, collection efficiency and distance dependence of the probes were characterized and first Raman measurements are presented. The advantages of the novel probes are discussed and further applications to Raman-on-chip detection schemes are described.

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“…It is also advantageous for micro-manipulation applications, such as Raman-based flow cytometry [13,14,16,37], because it provides a lot of space to install additional tools. In our case, it enables good direction of the tubings towards a microfluidic chip, thus preventing sedimentation of the cells on tube walls.…”

Section: How To Design the Mechanical Partmentioning

confidence: 99%

Design and first applications of a flexible Raman micro-spectroscopic system for biological imaging

Kiselev

Schie

Aškrabić

et al. 2016

BSI

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Abstract. Typical commercial Raman micro-spectroscopic systems do not offer much flexibility to the end user, thus limiting potential research applications. We present a design of a simple, highly flexible and portable confocal Raman microscope with a detailed list of parts. The system can perform spectral acquisition in different modes: single-point spectroscopy, hyperspectral point mapping or hyperspectral line mapping. Moreover, the microscope can be easily converted between inverted and upright configurations, which can be beneficial for specific situations. Fiber coupling enables to connect various lasers for excitation and spectrometer/CCD combinations for signal detection. The performance of the instrument is demonstrated via Raman spectroscopy at 785 nm excitation wavelength, single point mapping of pancreatic cancer cells placed onto a quartz substrate and line mapping of polystyrene beads.

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Raman-on-chip device and detection fibres with fibre Bragg grating for analysis of solutions and particles

Cited by 31 publications

References 16 publications

Qualitative analysis of desi ghee, edible oils, and spreads using Raman spectroscopy

Qualitative analysis of desi ghee, edible oils, and spreads using Raman spectroscopy

Multi-core fiber with integrated fiber Bragg grating for background free Raman sensing

Design and first applications of a flexible Raman micro-spectroscopic system for biological imaging

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