Ramadan Intermittent Fasting Affects Adipokines and Leptin/Adiponectin Ratio in Type 2 Diabetes Mellitus and Their First-Degree Relatives

Abdullah, Khaldoon Sadiq Ahmed; Al‐Habori, Molham; Al-Eryani, Ekram

doi:10.1155/2020/1281792

Cited by 10 publications

(24 citation statements)

References 74 publications

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“…Abdullah et al [14] investigated the effects of RF on adiponectin, leptin, leptin to adiponectin ratio (LAR), growth hormone (GH), human-sensitive C-reactive protein (hs-CRP), and diabetic and metabolic syndrome factors in patients with T2D, their first-degree relatives (FDRs), and healthy controls. The authors designed a cohort study involving 98 Yemeni male subjects aged 30-70 years old: 30 T2D, 37 FDRs of T2D patients, and 31 healthy control subjects.…”

Section: Impact Of Fasting On Diabetes and Metabolic Metricsmentioning

confidence: 99%

Ramadan fasting and diabetes (2020): The year in review

Hafidh

Ali

Abbas

et al. 2021

Journal of Diabetes and Endocrine Practice

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Review Article introduCtionRamadan fasting (RF) observed by adult Muslims entails abstinence from food, water, all oral substances, intravenous fluid therapy, and smoking between dawn and sunset during the 9 th month of the Muslims' lunar calendar. [1] Ramadan's impact on health and disease stems from the biological effects of prolonged fasting during the daytime and possible overfeeding at night and its various social changes. The last three decades witnessed a rising interest in the research on RF in health and disease. [2] Diabetes has been the most extensively studied single medical condition in connection with RF. [3] Despite the increase in volume of the literature, concern has been voiced regarding the quality of publications on the subject. [4,5] The literature on health aspects of Ramadan fasting (RF) is widely spread in many journals, making it not readily accessible to those interested in the subject. We therefore aimed to provide a thematic overview of the global research work conducted in the realm of RF during 2020 on the impact of RF in people with diabetes. We aimed to provide a concise bird's eye view of the literature published in a year and to identify the basis of evidence that may guide clinical practices for the years to come. matErials and mEthodsThis is a narrative, nonsystematic review of the literature retrieved from one online database over a full calendar year (2020). The PubMed search engine of the National Center for Biotechnology Information at the U.S. National Library of Medicine was used. The search term ("Ramadan Fasting" OR "Fast of Ramadan") AND diabetes, with time filters from January 1, 2020, to December 31, 2020, was used to identify the relevant records. Retrieved articles were examined forThe literature on health aspects of Ramadan fasting (RF) is widely spread in many journals, making it not readily accessible to those interested in the subject. We aimed to provide a narrative overview of the global literature production in 1 year (2020) on diabetes and RF. This was a narrative, nonsystematic review of the international literature from a single major medical online database (i.e., PubMed) during the year 2020. The search term "Ramadan fasting AND Diabetes" was used, and the relevant literature was narrated in a concise thematic account. The publications spanned a vast array of topics related to RF, including assessments of safety and efficacy profiles of older and newer diabetes therapies, modes of insulin delivery, evaluating the role of utilizing advanced technology for the treatment, and monitoring of blood glucose during RF. Increased interest was evident in capturing patients' perspectives and healthcare professionals' perceptions, attitudes, and practices during Ramadan. Fasting by high-risk groups was studied. Not surprisingly, some reports covered COVID-19 and Ramadan and the role of telemedicine in ramadan. The current literature review presents this year's research data on the safety of fasting practices, care models, and patients' experiences and perspectives....

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Section: Impact Of Fasting On Diabetes and Metabolic Metricsmentioning

confidence: 99%

Ramadan fasting and diabetes (2020): The year in review

Hafidh

Ali

Abbas

et al. 2021

Journal of Diabetes and Endocrine Practice

View full text Add to dashboard Cite

show abstract

“…Mechanistically, analysis of blood samples revealed no significant effect of the 3-day CR diet on circulating levels of insulin, ketone bodies (acetoacetic acid and 3-hydroxybutyric acid), cortisol, neuropeptide Y, protein YY, or ghrelin (Table 3). However, we did observe a significant increase in circulating levels of leptin, although variable changes in leptin with fasting have been reported [37,52], such an increase may be, in part, responsible for the greater lipolysis and fat oxidation [53]. While a tenable hypothesis, the current data and underlying measurements are limited to whole body estimates of substrate metabolism and future more invasive studies are required to confirm.…”

Section: Impact Of Short-term Cr On Metabolism and Substrate Utilizationmentioning

confidence: 48%

The Effects of Short-Term Caloric Restriction on Cardiometabolic Health in Overweight/Obese Men and Women

DeBlauw¹,

Churchill²,

Yunda³

et al. 2023

Preprint

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Overweight and Obesity (Ow/Ob) is a risk factor for developing cardiometabolic disease, and metabolic dysfunction. Dietary interventions, such as caloric restriction (CR), have been explored but little is known about the acute effects of CR and often such diets are not standardized. PURPOSE: To assess the impact of a standardized 3-day CR diet (~590kcal/d) on cardiometabolic health and fat metabolism in Ow/Ob individuals. METHODS: Fifteen Ow/Ob men and women were assessed pre-post 3-day CR using standardized diet; specifically, body weight/composition (% body fat, visceral fat score (Vfs), waist-hip circumferences, blood pressure and vascular stiffness, resting energy expenditure (REE), substrate utilization (respiratory quotient, RQ), and blood glucose/lipid profile. RESULTS: CR induced changes in body weight (93.1±15.2 to 90.67±14.4 kg, p&lt;0.001, d=1.9), body mass index (32.9±4.0 to 32.0±3.7 kg/m2, p&lt;0.001, d=1.4), body fat (37.2±7.5 to 35.8±7.5%, p=0.002, d=1.1) and Vfs (13.1±4.5 to 12.2±3.9 a.u., p=0.002, d=1.1), but not body water (46.3±3.6 to 46.0±3.6%, p=0.29, d=0.3). CR had no effect on peripheral (86±5 to 89±5 mmHg, p=0.23, d=0.3) or central mean arterial pressure (86±5 to 87±6 mmHg, p=0.44, d=0.2), but lowered augmentation index (29.8±17.5 to 21.5±14.5%, p=0.05, d=0.6). Blood glucose (86±7 to 84±11 mg/dl, p=0.33, d=0.3) and blood lipids (total cholesterol (196±49 to 203±54 mg/dl, p=0.16, d=0.4) and TC/HDL (4.9±2.4 to 6.1±4.7, p=0.13, d=0.4)) were unchanged. RQ decreased with CR (0.84±0.01 to 0.76±0.00, p&lt;0.001, d=1.9), though REE was unchanged (1718±274 to 1722±317 kcal/d, p=0.83, d=0.1). CONCLUSION: The 3-day CR significantly improved body weight and composition and fat metabolism, with minimal cardiovascular effects.

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“…Mechanistically, analysis of blood samples revealed no significant effect of the 3-day CR diet on circulating levels of insulin, 3-hydroxybutyric acid, cortisol, neuropeptide Y, protein YY, or ghrelin (Table 2). However, we did observe significant increases in acetoacetic acid (a ketone) and circulating levels of leptin, although variable changes in leptin with fasting have been reported (Abdullah et al, 2020;Jakobsdottir et al, 2016), such increases may be, in part, responsible for the greater lipolysis and fat oxidation (Harris, 2014). While a tenable hypothesis, the current data and underlying measurements are limited to whole body estimates of substrate metabolism and future more invasive studies are required to confirm.…”

Section: Impact Of Short-term Cr On Metabolism and Substrate Utilizationmentioning

confidence: 55%

The effects of short‐term caloric restriction on cardiometabolic health in overweight/obese men and women: A single‐arm trial

DeBlauw,

Churchill,

Yunda

et al. 2023

Physiological Reports

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Overweight and obesity (Ow/Ob) is a risk factor for cardiometabolic disease. Caloric restriction (CR) have been investigated but little is known about the acute effects of CR and often such diets are not standardized. Thus, we aimed to assess the impact of a new standardized 3‐day CR diet (590 kcal/d intake) on cardiometabolic health in weight‐stable Ow/Ob individuals. In a single‐arm design, 15 Ow/Ob men and women were assessed pre‐post a 3‐day standardized CR diet; specifically, body weight/composition (%body fat, visceral fat score (Vfs), blood pressure (BP), and vascular stiffness (VS), resting energy expenditure (REE), substrate utilization (respiratory quotient, RQ), and blood glucose/lipid profile). CR lowered body weight (93.1 ± 15.2 to 90.67 ± 14.4 kg, p < 0.001, d = 1.9), %fat (37.2 ± 7.5 to 35.8 ± 7.5%, p = 0.002, d = 1.1), and Vfs (13.1 ± 4.5 to 12.2 ± 3.9 a.u., p = 0.002, d = 1.1), but not body water (46.3 ± 3.6 to 46.0 ± 3.6%, p = 0.29). CR lowered VS (29.8 ± 17.5 to 21.5 ± 14.5%, p = 0.05, d = 0.6), but not BP (p > 0.05). Blood glucose (86 ± 7 to 84 ± 11 mg/dL, p = 0.33) and lipids (total cholesterol (196 ± 49 to 203 ± 54 mg/dL, p = 0.16) and TC/HDL (4.9 ± 2.4 to 6.1 ± 4.7, p = 0.13)) were unchanged. RQ decreased with CR (0.84 ± 0.01 to 0.76 ± 0.00, p < 0.001, d = 1.9), though REE was unchanged (p = 0.83). The 3‐day CR diet significantly improved fat metabolism, body weight and composition, and vascular stiffness.

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Ramadan Intermittent Fasting Affects Adipokines and Leptin/Adiponectin Ratio in Type 2 Diabetes Mellitus and Their First-Degree Relatives

Cited by 10 publications

References 74 publications

Ramadan fasting and diabetes (2020): The year in review

Ramadan fasting and diabetes (2020): The year in review

The Effects of Short-Term Caloric Restriction on Cardiometabolic Health in Overweight/Obese Men and Women

The effects of short‐term caloric restriction on cardiometabolic health in overweight/obese men and women: A single‐arm trial

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