Ramadan daily intermittent fasting reduces objectively assessed habitual physical activity among adults

Farooq, Abdualziz; Chamari, Karim; Sayegh, Suzan; Akoum, Maha El; Al-Mohannadi, Abdulla Saeed

doi:10.1186/s12889-021-11961-9

Cited by 18 publications

(14 citation statements)

References 32 publications

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“…To test the hypothesis that daily physical activity could be reduced among Muslims due to the inability to refuel and rehydrate in the fasting state, a cohort study was designed among adults registered with the national physical activity community program. 61 Data from a pedometer-based community program was used to extract 3 months of daily step counts before, during, and after Ramadan for 6 years. A survey was conducted among participants to determine fasting practice and other health and environmental factors.…”

Section: Impact Of Rf On Athletes' Well-beingmentioning

confidence: 99%

Ramadan Fasting in Health and Disease in 2021: A Narrative Review

Hassan-Beck

Hafidh

Badi³

et al. 2022

Ibnosina Journal of Medicine and Biomedical Sciences

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Introduction: The literature on the health aspects of Ramadan fasting (RF) is widely spread in many journals. Materials and Methods: This is a narrative review of data obtained from the PubMed database (National Library of Medicine, Bethesda, Maryland, United States). We used the search term “Ramadan fasting,” and relevant records were examined. The publications are narrated thematically. Results: The publications spanned fundamental, clinical, professional, cultural, and advocacy facets. The publications crossed conventional disciplinary lines and geographical locations and appeared in journals with different access systems. The contents are presented under the themes that emerged depending on the retrieved literature. This year basic coverage included changes in physiology and nutrition during Ramadan. However, the clinical issues included a wide range of topics. These included the impact of RF on nonalcoholic fatty liver disease and adjustments needed in endocrine replacement therapy for hypothyroidism and adrenal insufficiency. Coverage also included chronic kidney disease. The impact on maternal health, fetal well-being, and long-term effects of RF exposures were addressed in several studies. Studies in cardiovascular medicine focused on blood pressure and cardiovascular risk factors. Sports medicine and athletes' well-being received somewhat prominent coverage. The impact on renal function, particularly in patients with chronic kidney disease, was investigated by a few authors. Several groups addressed the eyes' structure and function, neurological conditions, especially headache disorders, and hematological and oncological conditions. Finally, the impact of RF on several aspects of mental health and well-being was addressed by various groups. Conclusions: Health aspects of RF received a sustained academic interest with a broad spectrum in 2021. This narration provides an overview of the year's scholarly health-related literature on various aspects of health and disease. It should help researchers and clinicians catch up quickly with the health concerns during Ramadan.

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Section: Impact Of Rf On Athletes' Well-beingmentioning

confidence: 99%

Ramadan Fasting in Health and Disease in 2021: A Narrative Review

Hassan-Beck

Hafidh

Badi³

et al. 2022

Ibnosina Journal of Medicine and Biomedical Sciences

View full text Add to dashboard Cite

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“…Energy expenditure allows the evaluation of overall metabolic efficiency by measuring the ability to convert ingested energy into fat and protein. [ 38 ] In an attempt to maintain bodyweight during fasting, energy expenditure is decreased by reducing physical activity [ 39 ] and diet‐induced thermogenesis. [ 40 ] Supporting this, Just et al previously showed that liver‐specific LKB1 KO had decreased locomotor activity.…”

Section: Discussionmentioning

confidence: 99%

LKB1 acts as a critical brake for the glucagon‐mediated fasting response

et al. 2022

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As important as the fasting response is for survival, an inability to shut it down once nutrients become available can lead to exacerbated disease and severe wasting. The liver is central to transitions between feeding and fasting states, with glucagon being a key initiator of the hepatic fasting response. However, the precise mechanisms controlling fasting are not well defined. One potential mediator of these transitions is liver kinase B1 (LKB1), given its role in nutrient sensing. Here, we show LKB1 knockout mice have a severe wasting and prolonged fasting phenotype despite increased food intake. By applying RNA sequencing and intravital microscopy, we show that loss of LKB1 leads to a dramatic reprogramming of the hepatic lobule through robust up‐regulation of periportal genes and functions. This is likely mediated through the opposing effect that LKB1 has on glucagon pathways and gene expression. Conclusion: Our findings show that LKB1 acts as a brake to the glucagon‐mediated fasting response, resulting in “periportalization” of the hepatic lobule and whole‐body metabolic inefficiency. These findings reveal a mechanism by which hepatic metabolic compartmentalization is regulated by nutrient‐sensing.

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“…Energy expenditure allows the evaluation of overall metabolic efficiency by measuring the ability to convert ingested energy into fat and protein 38 . In an attempt to maintain bodyweight during fasting, energy expenditure is decreased by reducing physical activity 39 and diet-induced thermogenesis 40 . Supporting this, Just and colleagues previously showed that liver specific LKB1 KO had decreased locomotor activity 21 .…”

Section: Discussionmentioning

confidence: 99%

LKB1 acts as a critical brake for the glucagon-mediated fasting response

Acevedo‐Acevedo

Stefkovich

Kang

et al. 2022

Preprint

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As important as the fasting response is for survival, an inability to shut it down once nutrients become available can lead to exacerbated disease and severe wasting. The liver is central to transitions between feeding and fasting states, with glucagon being a key initiator of the fasting response in the liver. However, the precise regulatory mechanisms behind glucagon-induced fasting are unclear. One potential mediator of these transitions is Liver Kinase B1 (LKB1) given its role in nutrient sensing. Here, we show LKB1 knockout mice have a severe wasting and prolonged fasting phenotype despite increased food intake. By applying RNA sequencing and intravital microscopy we show that loss of LKB1 leads to a dramatic reprogramming of the hepatic lobule through robust upregulation of periportal genes and functions. This is mediated through the opposing effect LKB1 has on glucagon signaling and gene expression. Conclusion: our findings show that LKB1 acts as a brake to the glucagon-mediated fasting response resulting in periportalization of the hepatic lobule and whole-body metabolic inefficiency. These findings reveal a new mechanism by which hepatic metabolic compartmentalization is regulated by nutrient-sensing.

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Ramadan daily intermittent fasting reduces objectively assessed habitual physical activity among adults

Cited by 18 publications

References 32 publications

Ramadan Fasting in Health and Disease in 2021: A Narrative Review

Ramadan Fasting in Health and Disease in 2021: A Narrative Review

LKB1 acts as a critical brake for the glucagon‐mediated fasting response

LKB1 acts as a critical brake for the glucagon-mediated fasting response

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