Raised dietary Zn:Cu ratio increases the risk of atherosclerosis in type 2 diabetes

Kärberg, Kati; Forbes, Alastair; Lember, Margus

doi:10.1016/j.clnesp.2022.05.013

Cited by 7 publications

(9 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There is currently much controversy about the protective or risk role of these essential trace elements on cardiovascular risk factors and diseases. This is because studies conducted on this topic over the past few decades have yielded inconsistent results [ 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 ]. Numerous variables [ 50 , 55 , 56 , 57 , 58 , 59 , 60 ] can impact the different results of studies in this field.…”

Section: Discussionmentioning

confidence: 99%

“…In this Mediterranean population, correlations between plasma concentrations and urine concentrations of these biomarkers were found to be quite weak. Depending on the biomarker utilized, these low correlations may account for the disparity in results across published studies [ 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 ]. Although the majority of published studies analyzed plasma, serum, or blood concentrations, other studies used urine biomarkers [ 97 , 124 , 127 , 128 , 129 , 130 , 131 , 132 , 133 ].…”

Section: Discussionmentioning

confidence: 99%

“…The ability of Mn to enhance oxidative stress is due to the transition of its oxidative state +2 to +3, which increases its pro-oxidant capacity [ 65 ]. However, the current emphasis is on the chronic effect of moderately high concentrations of these elements, given the growing evidence of an increased risk of cardiometabolic diseases such as diabetes, hypertension, dyslipidemias, and some cardiovascular outcomes [ 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 ]. Despite the large number of studies [ 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 ] that show a direct relationship between Se, Cu, Zn, or Mn and cardiovascular risk factors, there are other studies that show no associations or even an inverse relationship [ 51 , 78 , 79 , 80 , 81 , 82 , 83 , 84 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Single and Combined Associations of Plasma and Urine Essential Trace Elements (Zn, Cu, Se, and Mn) with Cardiovascular Risk Factors in a Mediterranean Population

et al. 2022

View full text Add to dashboard Cite

Trace elements are micronutrients that are required in very small quantities through diet but are crucial for the prevention of acute and chronic diseases. Despite the fact that initial studies demonstrated inverse associations between some of the most important essential trace elements (Zn, Cu, Se, and Mn) and cardiovascular disease, several recent studies have reported a direct association with cardiovascular risk factors due to the fact that these elements can act as both antioxidants and pro-oxidants, depending on several factors. This study aims to investigate the association between plasma and urine concentrations of trace elements and cardiovascular risk factors in a general population from the Mediterranean region, including 484 men and women aged 18–80 years and considering trace elements individually and as joint exposure. Zn, Cu, Se, and Mn were determined in plasma and urine using an inductively coupled plasma mass spectrometer (ICP-MS). Single and combined analysis of trace elements with plasma lipid, blood pressure, diabetes, and anthropometric variables was undertaken. Principal component analysis, quantile-based g-computation, and calculation of trace element risk scores (TERS) were used for the combined analyses. Models were adjusted for covariates. In single trace element models, we found statistically significant associations between plasma Se and increased total cholesterol and systolic blood pressure; plasma Cu and increased triglycerides and body mass index; and urine Zn and increased glucose. Moreover, in the joint exposure analysis using quantile g-computation and TERS, the combined plasma levels of Zn, Cu, Se (directly), and Mn (inversely) were strongly associated with hypercholesterolemia (OR: 2.03; 95%CI: 1.37–2.99; p < 0.001 per quartile increase in the g-computation approach). The analysis of urine mixtures revealed a significant relationship with both fasting glucose and diabetes (OR: 1.91; 95%CI: 1.01–3.04; p = 0.046). In conclusion, in this Mediterranean population, the combined effect of higher plasma trace element levels (primarily Se, Cu, and Zn) was directly associated with elevated plasma lipids, whereas the mixture effect in urine was primarily associated with plasma glucose. Both parameters are relevant cardiovascular risk factors, and increased trace element exposures should be considered with caution.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Single and Combined Associations of Plasma and Urine Essential Trace Elements (Zn, Cu, Se, and Mn) with Cardiovascular Risk Factors in a Mediterranean Population

et al. 2022

View full text Add to dashboard Cite

show abstract

“…French women prospective cohort study 70991 Higher Cu/Zn ratio appeared to be associated with higher T2D risk for women with zinc intake <8 mg day −1 (Laouali et al, 2021) [45] Food frequency questionnaire T2D patients without a diagnosis of atherosclerosis or its complications 216 A high dietary Zn/Cu ratio derived from an unbalanced diet in patients with T2DM is significantly related to atherosclerosis (Karberg et al, 2022) [46] Plasma Cu concentration [49] Plasma Cu concentration T2D patients 5278 Cu was positively associated with all-cause mortality, Only plasma iron has been significantly associated with decreased risk of CVD mortality (Li et al, 2023) [50] Plasma Cu concentration T1D patients 63 Total Cu and ceruloplasmin levels were higher in persons with T1D compared to healthy controls.…”

Section: Diabetic Vasculopathymentioning

confidence: 99%

“…[ 45 ] However, in the diabetic state, a low dietary Cu/Zn ratio in patients with T2D is significantly related to the incidence of atherosclerosis. [ 46 ] Suggesting only observe dietary copper and zinc intake is not enough to determine the correlation with diabetes. In addition, food frequency questionnaire research is susceptible to subjective and accidental influences, more rigorous and controlled research is needed to confirm the relationship between dietary copper and diabetes.…”

Section: Copper and Diabetesmentioning

confidence: 99%

Copper and Diabetes: Current Research and Prospect

Chang,

2023

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Copper is an essential trace metal for normal cellular functions; a lack of copper is reported to impair the function of important copper‐binding enzymes, while excess copper could lead to cell death. Numerous studies have shown an association between dietary copper consumption or plasma copper levels and the incidence of diabetes/diabetes complications. And experimental studies have revealed multiple signaling pathways that are triggered by copper shortages or copper overload in diabetic conditions. Moreover, studies show that treated with copper chelators improve vascular function, maintain copper homeostasis, inhibit cuproptosis, and reduce cell toxicity, thereby alleviating diabetic neuropathy, retinopathy, nephropathy, and cardiomyopathy. However, the mechanisms reported in these studies are inconsistent or even contradictory. This review summarizes the precise and tight regulation of copper homeostasis processes, and discusses the latest progress in the association of diabetes and dietary copper/plasma copper. Further, the study pays close attention to the therapeutic potential of copper chelators and copper in diabetes and its complications, and hopes to provide new insight for the treatment of diabetes.

show abstract

A machine learning-based diagnosis modelling of type 2 diabetes mellitus with environmental metal exposure

Zhao

Jin

Qin

et al. 2023

Computer Methods and Programs in Biomedicine

View full text Add to dashboard Cite

Raised dietary Zn:Cu ratio increases the risk of atherosclerosis in type 2 diabetes

Cited by 7 publications

References 42 publications

Single and Combined Associations of Plasma and Urine Essential Trace Elements (Zn, Cu, Se, and Mn) with Cardiovascular Risk Factors in a Mediterranean Population

Single and Combined Associations of Plasma and Urine Essential Trace Elements (Zn, Cu, Se, and Mn) with Cardiovascular Risk Factors in a Mediterranean Population

Copper and Diabetes: Current Research and Prospect

A machine learning-based diagnosis modelling of type 2 diabetes mellitus with environmental metal exposure

Contact Info

Product

Resources

About