Raised dietary <i>n</i>‐6 polyunsaturated fatty acid intake increases 2‐series prostaglandin production during labour in the ewe

Elmes, M; Green, Lucy; Poore, Kirsten R.; Newman, James; Burrage, D.; Abayasekara, D R E; Cheng, Zhangrui; Hanson, Mark A.; Wathes, D C

doi:10.1113/jphysiol.2004.071969

Cited by 24 publications

(20 citation statements)

References 44 publications

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“…It is generally accepted that the onset of labour in most mammalian species including sheep is associated with an increase in n-6-derived two-series PGs , Olson 2003, Myatt & Sun 2010 produced by the intrauterine tissues (placenta, amnion, chorion, decidua/ endometrium and myometrium) (sheep: Rice et al 1990, 1995, Thorburn 1991, McLaren et al 1996, 2000guinea pig: Welsh et al 2005;human: Slater et al 1999, Sawdy et al 2000. Rats, humans and sheep fed a high n-6 PUFA diet have been shown to have shortened pregnancies (Olsen & Secher 1990, Olsen et al 1991, Elmes et al 2005, while animals (e.g. sheep) and humans (e.g.…”

Section: Introductionmentioning

confidence: 99%

Polyunsaturated fatty acids modulate prostaglandin synthesis by ovine amnion cells in vitro

Kirkup

Cheng²,

Elmes³

et al. 2010

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Diets or supplements high in n-3 and n-6 polyunsaturated fatty acids (PUFAs) have been shown to influence the timing of parturition. PUFAs are substrates for prostaglandin (PG) synthesis, and PGs play central roles in parturition. Hence, the effects of altering PUFA composition may be mediated through alterations in the type and relative quantities of PGs synthesised. Therefore, we have investigated the effects of a range of n-3 and n-6 PUFAs in vitro on PG synthesis by amnion cells of late gestation ewes. The n-6 PUFA, arachidonic acid (20:4, n-6), increased synthesis of two-series PGs. Degree of stimulation induced by the n-6 PUFAs was dependent on the position of the PUFA in the PG synthetic pathway, i.e. PG production of the two-series (principally prostaglandin E 2 :PGE 2 ) increased progressively with longer chain PUFAs. Effects of n-3 PUFAs on output of PGE 2 were more modest and variable. The two shorter chain n-3 PUFAs, a-linolenic acid (18:3, n-3) and stearidonic acid (18:4, n-3), induced a small but significant increase in PGE 2 output, while the longest chain n-3 PUFA docosahexaenoic acid (22:6, n-3) inhibited PGE 2 synthesis. Dihomo-g-linolenic acid (20:3, n-6), the PUFA substrate for synthesis of one-series PGs, induced an increase in PGE 1 generation and a decrease in PGE 2 and PGE 3 outputs. Hence, we have demonstrated that PUFA supplementation of ovine amnion cells in vitro affects the type and quantity of PGs synthesised.

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Section: Introductionmentioning

confidence: 99%

Polyunsaturated fatty acids modulate prostaglandin synthesis by ovine amnion cells in vitro

Kirkup

Cheng²,

Elmes³

et al. 2010

Reproduction

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“…However, pregnant and lactating women who consume greater quantities of DHA have lower levels of AA in their milk and blood, and AA levels are lower in their offspring [17,20,55,58,59] . While the inclusion of AA in postnatal diets offsets the negative effects of high n3 diets, supplementation of pregnant women with AA or its precursor is not recommended since this may increase placental production of prostaglandins that can increase the risk of preterm labor [55,[60][61][62] .…”

Section: Discussionmentioning

confidence: 99%

The Effects of Maternal Dietary Docosahexaenoic Acid Intake on Rat Pup Myelin and the Auditory Startle Response

et al. 2007

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We investigated the effects of maternal docosahexanoic acid (DHA) supplementation on pups’ auditory startle responses and the composition of brain myelin. Methods: Timed-pregnant rats were fed throughout pregnancy and lactation diets that contained 0, 0.3, 0.7 or 3% of total fatty acids as DHA. Milk was collected from culled pups’ stomachs on postnatal day (PND) 3, latency of the auditory startle reflex was measured on PND 15, and pups were killed and brains collected on PND 24. Results: Higher levels of DHA in maternal diet were reflected in milk and in pups’ myelin. The latency of the auditory startle response was significantly longer in offspring of dams fed higher levels of DHA. There was a positive correlation between the myelin content of DHA and the latency of the startle response (p = 0.044), and a negative correlation between the myelin content of DHA and the myelin content of cholesterol (p = 0.005). Conclusion: High levels of maternal DHA intake alter the lipid composition of rat pup myelin, and are associated with longer latencies of the auditory startle response – a myelin-dependent electrophysiologic response.

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“…Estos ácidos grasos son metabolizados dentro del cuerpo del animal en ácido araquidónico, el cual es precursor de la síntesis de prostaglandinas E2 y F2α en el tejido uterino y placentario (10) . Así, en ovejas alimentadas en el preparto con dietas altas en AS, se ha observado la presencia de partos prematuros producto de un incremento en niveles circulantes sanguíneos de prostaglandinas (9,31,32) . En ovinos, el parto prematuro se considera como una de las principales causas de morbilidad, mortalidad y bajo crecimiento de las crías en los primeros días posparto (33) .…”

Section: Peso Al Nacimiento Y Desarrollo De Las Críasunclassified

“…En ovejas, la síntesis de prostaglandinas E2 y F2α placentarias se incrementa por la adición de aceites vegetales en la dieta preparto, situación que favorece la incidencia de partos prematuros (9) . Los corderos que nacen prematuramente se caracterizan por ser débiles y con bajos pesos al nacimiento (10) .…”

Section: Introductionunclassified

Síntesis de calostro y desarrollo de las crías por efecto de la inclusión de aceite de soya en la dieta preparto de ovejas de pelo

Vazquez

Vicente-Pérez

Osorio

et al. 2017

Rev. Mex. Cienc. Pecu.

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El objetivo fue evaluar el efecto del nivel de inclusión de aceite de soya (AS) en la dieta pre-parto de ovejas de pelo sobre la producción y composición del calostro, desarrollo de las crías en los primeros 10 días postparto y la productividad de la oveja al parto. Un grupo de ovejas multíparas preñadas Katahdin x Pelibuey se asignaron a tres tratamientos (n=10), los cuales consistieron en dietas isoenergéticas e isoprotéicas que contenían: 0, 3 y 6 % de AS/kg de materia seca. Las dietas se ofrecieron del día 100 de gestación al parto. El peso y volumen del calostro aumentaron linealmente (P <0.05) conforme el nivel de AS en la dieta incrementó. El resto de las variables no presentaron efectos lineales ni cuadráticos (P >0.05) por nivel de AS. Entre ovejas alimentadas con y sin AS, o entre ovejas alimentadas con 3 y 6 % de AS, no se observaron diferencias (P>0.05) en peso vivo y condición corporal de las ovejas, así como en la composición del calostro, peso al nacimiento de las crías y el peso de camada al parto. Se concluye que la adición de 3 o 6 % de AS en la dieta preparto de ovejas de pelo no afectó la composición del calostro, el desarrollo de las crías ni la productividad de la oveja, pero sí afectó la producción de calostro, la cual fue mayor al nivel de 6 % de AS en la dieta. PALABRAS CLAVE: Ovejas preñadas, Nutrición materna, Aceite de soya, Producción de calostro. ABSTRACTThe objective was to evaluate the effect of the inclusion level of soybean oil (SBO) in the prepartum diet of hair ewes on the colostrum production and composition, development of lambs at d 10 post-lambing and ewe productivity at lambing. A group of pregnant multiparous ewes from Katahdin x Pelibuey genotype were assigned to three treatments (n=10), which consisted of isoenergetic and isoproteic diets containing: 0, 3 and 6 % of SBO/kg dry matter. Diets were offered from d 100 of gestation to lambing. The colostrum weight and volume increased linearly (P<0.05) as the SBO level in diet increased. The rest of variables did not show any linear or quadratic effect (P >0.05) as the SBO level changed from 0 to 6 %. Between ewes fed with or without SBO, or between ewes fed 3 and 6 % of SBO, no difference was detected (P >0.05) on live weight and body condition score of ewes, as well as on colostrum composition, lamb birth weight and litter weight at lambing. In conclusion, the addition of 3 or 6 % of SBO to prepartum diets of hair ewes did not affect the colostrum composition, the development of lambs or the ewe productivity, but affected the colostrum production, being greater when 6 % of SBO was used in the diet.

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Raised dietary n‐6 polyunsaturated fatty acid intake increases 2‐series prostaglandin production during labour in the ewe

Cited by 24 publications

References 44 publications

Polyunsaturated fatty acids modulate prostaglandin synthesis by ovine amnion cells in vitro

Polyunsaturated fatty acids modulate prostaglandin synthesis by ovine amnion cells in vitro

The Effects of Maternal Dietary Docosahexaenoic Acid Intake on Rat Pup Myelin and the Auditory Startle Response

Síntesis de calostro y desarrollo de las crías por efecto de la inclusión de aceite de soya en la dieta preparto de ovejas de pelo

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