Raised cord serum immunoglobulin E increases the risk of allergic sensitisation at ages 4 and 10 and asthma at age 10

Sadeghnejad, Alireza; Karmaus, Wilfried; Davis, Stephanie D.; Kurukulaaratchy, Ramesh; Matthews, S.; Arshad, Syed Hasan

doi:10.1136/thx.2004.024224

Cited by 51 publications

(77 citation statements)

References 37 publications

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“…We observed much higher CB levels of PARC (CCL18) than of the other chemokines, however, possibly indicating a less strict regulation of this chemokine. Our inability to determine differences in CB PARC (CCL18) and eotaxin Similar to other studies, we found that high CB IgE levels were associated with allergic disease in the offspring (31,32). In addition, we found that the maternal IgE levels during pregnancy influence the CB IgE levels, since significant correlations occurred at gestational week 15, 39 and 12 months after delivery.…”

Section: Discussionsupporting

confidence: 84%

“…The study comprised 20 allergic (mean age (range) 30.8 years (24-38), mean number of previous successful pregnancies 0.55 (0-2)) and 36 non-allergic (mean age (range) 30.8 years (22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40), mean number of previous successful pregnancies 0.81 (0-2)) pregnant women from the Linköping area, County of Östergötland, Sweden. Due to technical and practical reasons, it was not possible to perform this study with a larger number of participants.…”

Section: Study Groupmentioning

confidence: 99%

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Cord blood cytokines and chemokines and development of allergic disease

Sandberg

Frykman

Ernerudh

et al. 2009

Pediatric Allergy Immunology

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Exposure to ubiquitous allergens early in life, even before birth, may influence the incidence of allergic diseases later in life. During pregnancy, the fetomaternal interface is surrounded by high levels of T-helper (Th)2-like cytokines, possibly favouring the development of Th2-like immune responses in the offspring. The aim of this study was to evaluate the relation between cord blood (CB) IgE antibodies, Th1- and Th2-like cytokines and chemokines, maternal allergy and development of allergic disease during the first 2 yr of life in the offspring. The CB cytokine and chemokine levels from children of 20 allergic and 36 non-allergic women were determined by a multiplexed Luminex assay and ELISA. Total CB and maternal IgE antibody concentrations were quantified using ImmunoCAP technology. The maternal IgE levels during and after pregnancy correlated with CB IgE and Th2-associated macrophage-derived chemokine [MDC (CCL22)] levels. Development of allergic disease and sensitization was associated with increased CB IgE and MDC (CCL22) levels, as well as high ratios of MDC (CCL22) to Th1-associated interferon-gamma inducible protein 10 [IP-10 (CXCL10)] and interferon-gamma inducible T-cell alpha-chemoattractant [I-TAC (CXCL11) (n = 7 allergic vs. n = 25 non-allergic)]. The correlations between maternal IgE and CB IgE and MDC (CCL22) levels possibly indicate that the maternal immunity can affect the Th1/Th2 profile in the neonate. Development of allergic disease is associated with a more marked Th2-like deviation already at birth, shown as increased levels of CB IgE and MDC (CCL22) and higher ratios of MDC (CCL22) to IP-10 (CXCL10) and I-TAC (CXCL11).

This is the pre-reviewed version of the following article: Martina Sandberg, Anne Frykman, Jan Ernerudh, Göran Berg, Leif Matthiesen, Christina Ekerfelt, Lennart Nilsson and Maria Jenmalm, Cord blood cytokines and chemokines and development of allergic disease, 2009, PEDIATRIC ALLERGY AND IMMUNOLOGY, (20), 6, 519-527. which has been published in final form at: http://dx.doi.org/10.1111/j.1399-3038.2008.00794.x Copyright: Blackwell Publishing Ltd http://www.blackwellpublishing.com/

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Section: Discussionsupporting

confidence: 84%

Section: Study Groupmentioning

confidence: 99%

Cord blood cytokines and chemokines and development of allergic disease

Sandberg

Frykman

Ernerudh

et al. 2009

Pediatric Allergy Immunology

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“…In line with this, several studies suggest that a maternal history of allergic disease constitutes a greater risk than paternal for development of infant allergic disease (Lim et al 2010). Maternal, but not paternal, total IgE levels have been found to correlate with cord blood IgE levels and allergy in the infant (Liu et al 2003), and Sadegnejad et al observed a stronger association between increased cord blood IgE levels and allergic disease in the mother than in the father (Sadeghnejad et al 2004). Elevated cord blood IgE has been identified as a risk factor for allergic sensitization and asthma (Sadeghnejad et al 2004).…”

mentioning

confidence: 87%

“…Maternal, but not paternal, total IgE levels have been found to correlate with cord blood IgE levels and allergy in the infant (Liu et al 2003), and Sadegnejad et al observed a stronger association between increased cord blood IgE levels and allergic disease in the mother than in the father (Sadeghnejad et al 2004). Elevated cord blood IgE has been identified as a risk factor for allergic sensitization and asthma (Sadeghnejad et al 2004). The observed Th2 deviation during pregnancy not only remains one year after pregnancy but may also influence further development of allergy in the offspring.…”

mentioning

confidence: 99%

Reduced IFN-γ and IL-10 responses to paternal antigens during and after pregnancy in allergic women

Persson

Ekerfelt

Ernerudh

et al. 2012

Journal of Reproductive Immunology

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“…Prenatal immune-system programming is also very important in the development of allergies such as asthma. Infants with a raised level of cord serum IgE -an immune marker of sensitization to allergens and asthma -were 66% more likely to develop asthma by 10 years of age (Sadeghnejad et al 2004).…”

Section: Drug Addiction and Reproduction From The Transgenerational Pmentioning

confidence: 99%

Bioscience-bioethics and life factors affecting reproduction with special reference to the Indigenous Australian population

Pollard

2005

Reproduction

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The demand for equality of recognition or respect is the dominant passion of modernity. The 20th century experienced a giant leap in technological inventiveness and ruthless use of technological power. In the 21st century, human welfare and environmental wellbeing demand fundamental political appraisal. We have the means, if we choose, to eradicate poverty and to responsibly protect the global environment. However, economic, political and cultural systems act to differentially allocate the benefits and risks for growth between socioeconomic groups. For example, it is a matter of pride that the neonatal mortality rate in affluent societies has dropped substantially since the late 1970s. However, the level of infant mortality (three times the national average) and low birthweight (13%) among the Indigenous Australian population is the highest in the country. With hindsight we now know that is the inevitable legacy of Australia's colonial history. Chronic physical and psychological stress is recognized as an important etiological factor in many lifestyle diseases of the cardiovascular, immune and reproductive systems. Diseases of adaptation are further advanced by non-adaptive lifestyle choices, depression, alcoholism and other drug dependencies. This review describes the principles of bioscience ethics and targets equity issues as they affect human reproduction across generations with particular reference to the Indigenous population of Australia. The review also considers ways we may advance global and cultural maturity from the Indigenous Australian perspective and proposes an ecologically based model of preventative care. If we are to embrace fundamental social change and protect future children without threatening parents' basic freedoms, then new beliefs and priorities -based on a compassionate understanding of biological systems -must evolve from the general public. Belief in human rights arising from a sense of human dignity is a collective outcome originating from individual commitment. The golden rule; that is, Nature's principle of reciprocity, is fundamental in bridging the gap between knowledge and effective action.

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Raised cord serum immunoglobulin E increases the risk of allergic sensitisation at ages 4 and 10 and asthma at age 10

Cited by 51 publications

References 37 publications

Cord blood cytokines and chemokines and development of allergic disease

Cord blood cytokines and chemokines and development of allergic disease

Reduced IFN-γ and IL-10 responses to paternal antigens during and after pregnancy in allergic women

Bioscience-bioethics and life factors affecting reproduction with special reference to the Indigenous Australian population

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