RAGE Signaling in Melanoma Tumors

Olaoba, Olamide Tosin; Kadasah, Sultan; Vetter, Stefan; Leclerc, Estelle

doi:10.3390/ijms21238989

Cited by 17 publications

(16 citation statements)

References 267 publications

(336 reference statements)

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“…Numerous studies, ranging from clinical studies to molecular analyses, have highlighted a strong contribution of inflammation to the development of MM and other cancers. There is also evidence that the presence of inflammatory proteins in the tumor milieu, whether derived from intrinsic pathways of inflammation (melanoma cells) or extrinsic pathways (the preceding SARS-CoV-2 infection, other sources of innate immunity, genetics, tissue damage, or autoimmune disease) promote melanoma cell survival, proliferation, migration, angiogenesis, lymphangiogenesis, and invasion ( 14 – 19 , 23 – 26 ). These intrinsic and extrinsic pathways of inflammation also signal the development and accumulation of myeloid-derived suppressor cells and tumor-associated macrophages, which result in T-cell tolerance and suppression of the antitumor immune response, thereby facilitating tumor growth ( 24 , 27 – 29 ).…”

Section: Discussionmentioning

confidence: 99%

Case Report: Malignant Melanoma Associated With COVID-19: A Coincidence or a Clue?

et al. 2022

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Following SARS-CoV-2 infection in humans, there is upregulation of proinflammatory molecules S100 calcium binding protein B (S100B), high-mobility group box-1 (HMGB1), osteopontin (OPN), tumor necrosis factor alpha (TNF-α), and other cytokines that promote hyperinflammation. The same immunoregulatory proteins that fuel the COVID-19 “cytokine storm” are also produced by melanoma cells and various other cancers to promote tumorigenesis. We report three cases of malignant melanoma (MM) associated with severe COVID-19, the first two with amelanotic melanoma and the third with hypopigmented melanoma. It is noteworthy that we did not search for these cases. Patient 1 is a personal acquaintance and cases 2 and 3 were hospitalized and worked at our rehabilitation center, respectively. We hypothesize that SARS-CoV-2 induced inflammatory tumorigenic proteins in the microenvironment that may have contributed to the de novo development (case 1), aggressive growth (case 2), or recurrence (case 3) of these malignant tumors. Moreover, high concentrations of the same proinflammatory proteins found in the “cytokine storm” associated with COVID-19, including TNF-α, interleukin (IL)-1α, IL-1β, IL-6, and ferritin, also induce skin depigmentation or hypopigmentation by interfering with tyrosinase synthesis, the enzyme that catalyzes the rate-limiting step of pigmentation. Hence, the marked elevation of the biological effectors that decrease skin pigmentation may also reduce pigmentation in MMs, resulting in amelanotic or hypopigmented lesions. Although it is certainly possible that the occurrence of melanoma following COVID-19 is coincidental, the ability of SARS-CoV-2 to increase expression of proinflammatory and tumorigenic molecules warrants further investigations to determine if there is an association between these disease processes or implications for patients with melanoma or other cancers who develop COVID-19.

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Section: Discussionmentioning

confidence: 99%

Case Report: Malignant Melanoma Associated With COVID-19: A Coincidence or a Clue?

et al. 2022

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“…The RAGE/ligand axis appears to support the association between chronic inflammation and immunosuppression. Therefore, targeting RAGE in melanoma tumors could be therapeutically beneficial [26].…”

Section: Prognostic Tissue Biomarkersmentioning

confidence: 99%

Unraveling the Wide Spectrum of Melanoma Biomarkers

et al. 2021

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The use of biomarkers in medicine has become essential in clinical practice in order to help with diagnosis, prognostication and prediction of treatment response. Since Alexander Breslow’s original report on “melanoma and prognostic values of thickness”, providing the first biomarker for melanoma, many promising new biomarkers have followed. These include serum markers, such as lactate dehydrogenase and S100 calcium-binding protein B. However, as our understanding of the DNA mutational profile progresses, new gene targets and proteins have been identified. These include point mutations, such as mutations of the BRAF gene and tumour suppressor gene tP53. At present, only a small number of the available biomarkers are being utilised, but this may soon change as more studies are published. The aim of this article is to provide a comprehensive review of melanoma biomarkers and their utility for current and, potentially, future clinical practice.

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“…AGEs have been shown to increase melanoma cell proliferation and migration, tumor growth, and metastasis through the interaction with their receptor (RAGE) on the melanoma cell surface. The blockade of the AGE/RAGE axis prevents tumor growth and inhibits angiogenesis [56].…”

Section: Red and Processed Meatmentioning

confidence: 99%

Nutritional Interventions for Patients with Melanoma: From Prevention to Therapy—An Update

et al. 2021

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Melanoma is an aggressive skin cancer, whose incidence rates have increased over the past few decades. Risk factors for melanoma are both intrinsic (genetic and familiar predisposition) and extrinsic (environment, including sun exposure, and lifestyle). The recent advent of targeted and immune-based therapies has revolutionized the treatment of melanoma, and research is focusing on strategies to optimize them. Obesity is an established risk factor for several cancer types, but its possible role in the etiology of melanoma is controversial. Body mass index, body surface area, and height have been related to the risk for cutaneous melanoma, although an ‘obesity paradox’ has been described too. Increasing evidence suggests the role of nutritional factors in the prevention and management of melanoma. Several studies have demonstrated the impact of dietary attitudes, specific foods, and nutrients both on the risk for melanoma and on the progression of the disease, via the effects on the oncological treatments. The aim of this narrative review was to summarize the main literature results regarding the preventive and therapeutic role of nutritional schemes, specific foods, and nutrients on melanoma incidence and progression.

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RAGE Signaling in Melanoma Tumors

Cited by 17 publications

References 267 publications

Case Report: Malignant Melanoma Associated With COVID-19: A Coincidence or a Clue?

Case Report: Malignant Melanoma Associated With COVID-19: A Coincidence or a Clue?

Unraveling the Wide Spectrum of Melanoma Biomarkers

Nutritional Interventions for Patients with Melanoma: From Prevention to Therapy—An Update

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