RAGE and Its Ligands in Melanoma

Leclerc, Estelle

doi:10.5772/59172

Cited by 1 publication

(1 citation statement)

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“…As a result, secretion of inflammatory cytokines such as IL-6, IL-1β, TNF-α, cell adhesion molecules (VCAM1, ICAM1, and endothelin1), and vascular endothelial growth factor is elevated, causing inflammation and angiogenesis. In addition to AGEs, some of the known ligands of RAGE are S100 proteins, high mobility group box 1, prion, and Mac-1 [ 28 ]. Previously, many studies have reported that an increase in Glo1 expression and activity attenuates MGO-induced oxidative stress and AGEs production in kidney cells [ 29 , 30 ].…”

Section: Methylglyoxal and Glyoxalmentioning

confidence: 99%

Glyoxalase System in the Progression of Skin Aging and Skin Malignancies

Yumnam

Subedi

Kim

2020

IJMS

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Dicarbonyl compounds, including methylglyoxal (MGO) and glyoxal (GO), are mainly formed as byproducts of glucose metabolism. The main glyoxalase system consists of glyoxalase I and II (Glo1 and Glo2) and is the main enzyme involved in the detoxification of dicarbonyl stress, which occurs as an accumulation of MGO or GO due to decreased activity or expression of Glo1. Dicarbonyl stress is a major cause of cellular and tissue dysfunction that causes various health issues, including diabetes, aging, and cancer. The skin is the largest organ in the body. In this review, we discuss the role of the glyoxalase system in the progression of skin aging, and more importantly, skin malignancies. We also discuss the future prospects of the glyoxalase system in other skin abnormalities such as psoriasis and vitiligo, including hyperpigmentation. Finally, in the present review, we suggest the role of glyoxalase in the progression of skin aging and glyoxalase system as a potential target for anticancer drug development for skin cancer.

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Section: Methylglyoxal and Glyoxalmentioning

confidence: 99%