RAFT polymerisation of <i>N</i>-vinylformamide and the corresponding double hydrophilic block copolymers

Dupre--Demorsy, Alexis; Kurowska, Izabela; Balayssac, Stéphane; Hennetier, Marie; Ric, Audrey; Bourdon, Valérie; Ando, Tetsu; Ajiro, Hiroharu; Coutelier, Olivier; Destarac, Mathias

doi:10.1039/d2py00925k

Polym. Chem.

2022

DOI: 10.1039/d2py00925k

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RAFT polymerisation of N-vinylformamide and the corresponding double hydrophilic block copolymers

Alexis Dupre--Demorsy

Izabela Kurowska

Stéphane Balayssac

et al.

Abstract: Reversible addition-fragmentation chain transfer (RAFT) homopolymerization of N-vinylformamide (NVF) is reported for the first time. Reactions were conducted in DMSO at 35°C using a xanthate RAFT agent. PNVFs of predetermined...

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2024

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Characterization and Performance Analysis of Hydrolyzed versus Non-Hydrolyzed Poly(NVF-co-HEA) Hydrogels for Cosmetic Applications

Yooyod,

Pinthong,

Mahasaranon

et al. 2024

Gels

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This study explores the synthesis and modification of poly(N-vinylformamide-co-N-hydroxyethyl acrylamide) (poly(NVF-co-HEA)) hydrogels for cosmetic applications. Poly(NVF-co-HEA) hydrogels were produced followed by an acid hydrolysis reaction to produce poly(NVF-co-VAm-co-HEA) hydrogels, introducing poly(vinyl amine) (PVAm) into the structure. This modification considerably alters the hydrogels’ properties, yielding materials with over 96% water content, predominantly in the form of non-freezing or free water, which is beneficial in the uptake and release of hydrophilic species. The primary amine groups from inclusion of VAm also improved the mechanical properties, as evidenced by an 8-fold increase in Young’s modulus. The hydrogels also possessed pH-responsive behavior, which was particularly noticeable under acidic and basic conditions, where a large decrease in water content was observed (40% to 75% reduction). Characterizing the hydrogels’ release capabilities involved using organic dyes of different functional groups and sizes to examine the pH impact on release. The results indicated that hydrolyzed hydrogels interacted more effectively with charged species, highlighting their suitability for pH-responsive delivery. The release of cosmetic active ingredients was also demonstrated through the controlled release of Liquid Azelaic™, specifically potassium azeloyl diglycinate (PAD). Our findings reveal that the hydrolyzed hydrogels exhibit superior burst release, especially under alkaline conditions, suggesting their suitability for cosmetic applications where controlled, pH-responsive delivery of active ingredients is desired. Overall, this investigation highlights the potential of hydrolyzed poly(NVF-co-HEA) hydrogels in cosmetic applications. Their ability to combine high water content with mechanical integrity, along with their pH-responsive release ability, allows for use in cosmetic formulations.

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Characterization and Performance Analysis of Hydrolyzed versus Non-Hydrolyzed Poly(NVF-co-HEA) Hydrogels for Cosmetic Applications

Yooyod,

Pinthong,

Mahasaranon

et al. 2024

Gels

View full text Add to dashboard Cite

show abstract

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RAFT polymerisation of N-vinylformamide and the corresponding double hydrophilic block copolymers

Abstract: Reversible addition-fragmentation chain transfer (RAFT) homopolymerization of N-vinylformamide (NVF) is reported for the first time. Reactions were conducted in DMSO at 35°C using a xanthate RAFT agent. PNVFs of predetermined...

Cited by 1 publication

References 55 publications

Characterization and Performance Analysis of Hydrolyzed versus Non-Hydrolyzed Poly(NVF-co-HEA) Hydrogels for Cosmetic Applications

Characterization and Performance Analysis of Hydrolyzed versus Non-Hydrolyzed Poly(NVF-co-HEA) Hydrogels for Cosmetic Applications

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