Raf1 interacts with OIP5 to participate in oxaliplatin-induced neuropathic pain

Yu, Wenli; Zheng, Zhenli; Wei, Wei; Li, Lei; Zhang, Yidan; Sun, Yanyan; Cao, Jing; Zang, Weidong

doi:10.1016/j.lfs.2021.119804

Cited by 5 publications

(3 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…G protein-coupled receptors, ion channels, circRNAs, and lncRNAs are critical in the modulation and transmission of nociceptive information ( Zhao et al, 2013 ; Gottesman-Katz et al, 2021 ; Han et al, 2021 ; Yu et al, 2021 ; Zheng et al, 2021 ). An approximate of 177 (92 upregulated and 85 downregulated) DEGs on CFA3D and 192 (107 upregulated and 85 downregulated) DEGs on CFA6D were identified as GPCR mRNAs in the TG after TMD.…”

Section: Resultsmentioning

confidence: 99%

“…Highest differentially expressed G proteincoupled receptor mRNAs, ion channel mRNAs, circular RNAs, and long noncoding RNAs in the trigeminal ganglion after temporomandibular joint disorders G protein-coupled receptors, ion channels, circRNAs, and lncRNAs are critical in the modulation and transmission of nociceptive information (Zhao et al, 2013;Gottesman-Katz et al, 2021;Han et al, 2021;Yu et al, 2021;Zheng et al, 2021). 4A,B) and ion channel (Figures 4C,D) in the TG on CFA3D and CFA6D, respectively, after TMD are displayed in the heatmaps.…”

Section: Altered Expression Profiles Of Mrnas Circular Rnas and Long ...mentioning

confidence: 99%

See 1 more Smart Citation

RNA sequencing profiling of mRNAs, long noncoding RNAs, and circular RNAs in Trigeminal Ganglion following Temporomandibular Joint inflammation

Liu

Zhao

Han

et al. 2022

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Patients with temporomandibular joint disorders (TMD) have high levels of inflammatory pain-related disability, which seriously affects their physical and mental health. However, an effective treatment is yet to be developed. Both circular RNAs (circRNAs) and long noncoding RNAs (lncRNAs) contribute to regulating pain conduction. In our current study, we report the expression profiles of circRNAs, lncRNAs, and mRNAs in the trigeminal ganglion (TG) associated with complete Freund’s adjuvant (CFA)-induced TMD inflammation pain. The collected TGs from the experimental (CFA) and control (saline) groups were processed for deep RNA sequencing. Overall, 1078,909,068 clean reads were obtained. A total of 15,657 novel lncRNAs were identified, where 281 lncRNAs were differentially expressed on CFA3D and 350 lncRNAs were differentially expressed on CFA6D. In addition, a total of 55,441 mRNAs and 27,805 circRNAs were identified, where 3,914 mRNAs and 91 circRNAs were found differentially expressed, between the CFA3D and saline groups, while 4,232 mRNAs and 98 DE circRNAs were differentially expressed between the CFA6D and saline groups. Based on functional analyses, we found that the most significant enriched biological processes of the upregulated mRNAs were involved in the immunity, neuron projection, inflammatory response, MAPK signaling pathway, Ras signaling pathway, chemokine signaling pathway, and inflammatory response in TG. Further analyses of Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes pathway suggest the involvement of dysregulated genes in the pain occurrence mechanism. Our findings provide a resource for expression patterns of gene transcripts in regions related to pain. These results suggest that apoptosis and neuroinflammation are important pathogenic mechanisms underlying TMD pain. Some of the reported differentially expressed genes might be considered promising therapeutic targets. The current research study revealed the expression profiles of circRNAs, lncRNAs, and mRNAs during TMD inflammation pain and sheds light on the roles of circRNAs and lncRNAs underlying the pain pathway in the trigeminal system of TMD inflammation pain.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Altered Expression Profiles Of Mrnas Circular Rnas and Long ...mentioning

confidence: 99%

RNA sequencing profiling of mRNAs, long noncoding RNAs, and circular RNAs in Trigeminal Ganglion following Temporomandibular Joint inflammation

Liu

Zhao

Han

et al. 2022

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

“…Then, cells were collected and live cells were counted by trypan blue (Solarbio Company, China) staining. Transfection was carried out with Lipofectamine 3000 (ThermoFisher, USA) as directed by the manufacturer and following previous reports [30,31]. PC12 cells were graciously provided by the Laboratory of Histoembryology, Zhengzhou University.…”

Section: Cell Culture and Transfectionmentioning

confidence: 99%

Prokineticin-2 Participates in Chronic Constriction Injury-Triggered Neuropathic Pain and Anxiety via Regulated by NF-κB in Nucleus Accumbens Shell in Rats

Wang,

Yuan,

et al. 2023

Mol Neurobiol

View full text Add to dashboard Cite

Neuropathic pain (NP) is an intractable pain that results from primary nervous system injury and dysfunction. Herein, we demonstrated in animal models that peripheral nerve injury induced enhanced pain perception and anxiety-like behaviors. According to previous reports, nucleus accumbens (NAc) shell is required for complete expression of neuropathic pain behaviors and mood alternations, we found the elevated mRNA and protein level of Prokineticin-2 (Prok2) in the NAc shell after Chronic Constriction Injury (CCI). Prok2 knockdown in the NAc shell reversed NP and anxiety-like behaviors in rats, indicating that Prok2 might play a fundamental role in NP and anxiety co-morbidity. CCI signi cantly enhanced Prok2 co-expression with NF-κB P-p65 in comparison with control animals. In addition to reversing the established nociceptive hypersensitivities and anxiety simultaneously, NAc microinjection of NF-κB siRNA or speci c inhibitor PDTC reversed Prok2 upregulation. Besides, Prok2 was signi cantly decreased in vitro when co-transfected with si-NF-κB. Dual-Luciferase assay showed NF-κB directly activated Prok2 gene transcriptional activity. Overall, these ndings provide new insights into the neurobiological mechanisms behind NP and comorbid anxiety. The NF-κB/Prok2 pathway could be a potential therapeutic target for NP and anxiety disorders.

show abstract

Cross-Talking Pathways of Rapidly Accelerated Fibrosarcoma-1 (RAF-1) in Alzheimer’s Disease

Hong,

Yu,

Cong

et al. 2023

Mol Neurobiol

View full text Add to dashboard Cite

Raf1 interacts with OIP5 to participate in oxaliplatin-induced neuropathic pain

Cited by 5 publications

References 36 publications

RNA sequencing profiling of mRNAs, long noncoding RNAs, and circular RNAs in Trigeminal Ganglion following Temporomandibular Joint inflammation

RNA sequencing profiling of mRNAs, long noncoding RNAs, and circular RNAs in Trigeminal Ganglion following Temporomandibular Joint inflammation

Prokineticin-2 Participates in Chronic Constriction Injury-Triggered Neuropathic Pain and Anxiety via Regulated by NF-κB in Nucleus Accumbens Shell in Rats

Cross-Talking Pathways of Rapidly Accelerated Fibrosarcoma-1 (RAF-1) in Alzheimer’s Disease

Contact Info

Product

Resources

About