Radon and Lung Cancer: Current Trends and Future Perspectives

Riudavets, Mariona; Herreros, Marta García de; Besse, Benjamin; Mezquita, Laura

doi:10.3390/cancers14133142

Cited by 61 publications

(60 citation statements)

References 81 publications

(118 reference statements)

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“…Lung cancer is the most prevalent malignancy in Chinese population, among whose histological subtypes, lung adenocarcinoma (LUAD) accounts for 40% of all lung cancer cases (1)(2)(3). The pathological diagnosis divides lung adenocarcinoma into atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), invasive adenocarcinoma (IAC), in which the former two are non-invasive and the latter two are invasive (4).…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: A predictive model based on ground glass nodule features via high-resolution CT for identifying invasiveness of lung adenocarcinoma

Yan

Chang²,

Jiang³

et al. 2022

Front. Surg.

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ObjectiveThe morphology of ground-glass nodule (GGN) under high-resolution computed tomography (HRCT) has been suggested to indicate different histological subtypes of lung adenocarcinoma (LUAD); however, existing studies only include the limited number of GGN characteristics, which lacks a systematic model for predicting invasive LUAD. This study aimed to construct a predictive model based on GGN features under HRCT for LUAD.MethodsA total of 301 surgical LUAD patients with HRCT-confirmed GGN were enrolled, and their GGN-related features were assessed by 2 individual radiologists. The pathological diagnosis of the invasive LUAD was established by pathologic examination following surgery (including 171 invasive and 130 non-invasive LUAD patients).ResultsGGN features including shorter distance from pleura, larger diameter, area and mean CT attenuation, more heterogeneous uniformity of density, irregular shape, coarse margin, not defined nodule-lung interface, spiculation, pleural indentation, air bronchogram, vacuole sign, vessel changes, lobulation were observed in invasive LUAD patients compared with non-invasive LUAD patients. After adjustment by multivariate logistic regression model, GGN diameter (OR = 1.490, 95% CI, 1.326–1.674), mean CT attenuation (OR = 1.007, 95% CI, 1.004–1.011) and heterogeneous uniformity of density (OR = 3.009, 95% CI, 1.485–6.094) were independent risk factors for invasive LUAD. In addition, a predictive model integrating these three independent GGN features was established (named as invasion of lung adenocarcinoma by GGN features (ILAG)), and receiver-operating characteristic curve illustrated that the ILAG model presented good predictive value for invasive LUAD (AUC: 0.919, 95% CI, 0.889–0.949).ConclusionsILAG predictive model integrating GGN diameter, mean CT attenuation and heterogeneous uniformity of density via HRCT shows great potential for early estimation of LUAD invasiveness.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: A predictive model based on ground glass nodule features via high-resolution CT for identifying invasiveness of lung adenocarcinoma

Yan

Chang²,

Jiang³

et al. 2022

Front. Surg.

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“…B[a]P is a polycyclic aromatic hydrocarbon (PAH) that is a recognized as a class I carcinogen that is present in tobacco, industrial exhaust, and environmental contamination. Additionally, arsenic [ 151 ], radon [ 152 ] and others environmental factors are etiologically related to lung cancer. For instance, it is known that tobacco smoking and second-hand smoke are etiologically related to 70–90% of lung cancer cases worldwide, though this percentage varies depending on the histological type and the sociodemographic factors that are involved [ 153 , 154 ].…”

Section: Hr-hpv-mediated Lung Carcinogenesis: Potential Mechanismsmentioning

confidence: 99%

High-Risk Human Papillomavirus Infection in Lung Cancer: Mechanisms and Perspectives

Osorio

Candia-Escobar

Corvalán

et al. 2022

Biology

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Lung cancer is a very prevalent and heterogeneous group of malignancies, and most of them are etiologically associated with tobacco smoking. However, viral infections have been detected in lung carcinomas, with high-risk human papillomaviruses (HR-HPVs) being among them. The role of HR-HPVs in lung cancer has been considered to be controversial. This issue is due to the highly variable presence of this virus in lung carcinomas worldwide, and the low viral load frequently that is detected. In this review, we address the epidemiological and mechanistic findings regarding the role of HR-HPVs in lung cancer. Some mechanisms of HR-HPV-mediated lung carcinogenesis have been proposed, including (i) HPV works as an independent carcinogen in non-smoker subjects; (ii) HPV cooperates with carcinogenic compounds present in tobacco smoke; (iii) HPV promotes initial alterations being after cleared by the immune system through a “hit and run” mechanism. Additional research is warranted to clarify the role of HPV in lung cancer.

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“…Mining-related lung cancer was first described by Harting Hesse in 1879 [ 8 ]. Since then, much work has been done, and an extensive account of the history of radon, lung cancer, and epidemiological studies can be found elsewhere [ 9 , 10 , 11 ]. In Poland, there are many underground tourist routes in mines and caves, which is why research was conducted on this subject [ 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Radon Exposure in the Underground Tourist Route–Historic Silver Mine in Tarnowskie Góry, Poland

Grygier

Skubacz

Wysocka

et al. 2022

IJERPH

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An assessment of the exposure of workers and tourists to radon in the underground tourist route of the Historic Silver Mine in Tarnowskie Góry was carried out. The study was conducted over a one-year period to capture seasonal variations in radon concentrations. CR-39 track detectors were used to measure radon concentrations, which were exposed in the mine during the following periods: 9 February 2021–19 May 2021, 19 May 2021–26 August 2021, 26 August 2021–25 November 2021 and 25 November 2021–3 March 2022. The annual average radon concentration along the tourist route was 1021 Bq m−3. The highest measured concentration was 2280 Bq m−3 and the lowest concentration was 80 Bq m−3. Based on the measured concentrations, effective doses were calculated, assuming that employees spend 1350 h a year in underground areas and that the time of visiting the mine by tourists is ca. 1 h. The average annual effective dose a worker would receive is approximately 2.5 mSv, and a tourist below 2 μSv. The dose limit expressed as the annual effective dose is 1 mSv for members of the general public and 20 mSv for occupational exposure.

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Radon and Lung Cancer: Current Trends and Future Perspectives

Cited by 61 publications

References 81 publications

RETRACTED: A predictive model based on ground glass nodule features via high-resolution CT for identifying invasiveness of lung adenocarcinoma

RETRACTED: A predictive model based on ground glass nodule features via high-resolution CT for identifying invasiveness of lung adenocarcinoma

High-Risk Human Papillomavirus Infection in Lung Cancer: Mechanisms and Perspectives

Radon Exposure in the Underground Tourist Route–Historic Silver Mine in Tarnowskie Góry, Poland

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