Radix Astragali and Radix Angelicae Sinensis in the Treatment of Idiopathic Pulmonary Fibrosis: A Systematic Review and Meta-analysis

Zhang, Yufeng; Gu, Lina; Xia, Qingqing; Tian, Lijun; Jia, Qi; Cao, Mengshu

doi:10.3389/fphar.2020.00415

Cited by 26 publications

(19 citation statements)

References 52 publications

(40 reference statements)

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“…Recently, a series of studies on the use of DGBXD for treating IPF were conducted. The obtained results confirmed the effectiveness and safety of RA and RAS in IPF patients [ 25 ] and clarified the multipathway, multitarget, and multicomponent mechanisms by which RA and RAS act in the treatment of IPF [ 26 , 27 ]. Therefore, DGBXD can effectively treat IPF by targeting multiple genes.…”

Section: Introductionsupporting

confidence: 62%

Danggui Buxue Decoction Ameliorates Idiopathic Pulmonary Fibrosis through MicroRNA and Messenger RNA Regulatory Network

Zhang

Wang

Shi

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To develop a putative microRNA (miRNA) and messenger RNA (mRNA) regulatory network of Danggui Buxue decoction’s (DGBXD) amelioration of idiopathic pulmonary fibrosis (IPF). Methods. The Gene Expression Omnibus (GEO) database was used to identify differentially expressed miRNAs (DE-miRNAs) and differentially expressed mRNAs (DE-mRNAs). Using miRNet, the predicted target genes of identified DE-miRNAs were estimated, and then the target genes of DE-miRNAs in IPF were comprehensively examined. The Enrichr database was used to conduct functional enrichment and pathway enrichment. Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) was employed to obtain the target genes of DGBXD as well as active compounds. A putative miRNA-mRNA regulatory network of DGBXD acting on IPF was developed by intersecting the target genes of DGBXD with the DE-miRNA target genes in IPF. A bleomycin-induced mouse model was established and used to perform histopathology as well as real-time quantitative polymerase chain reaction (qRT-PCR) analyses of some miRNA-mRNA pairs. Results. Fourteen upmodulated DE-miRNAs and six downmodulated DE-miRNAs were screened. The downstream target genes of upmodulated and downmodulated DE-miRNAs were predicted. Subsequently, 1160 upmodulated DE-mRNAs and 1427 downmodulated DE-mRNAs were identified. Then, target genes of DE-miRNAs comprising 49 downmodulated and 53 upmodulated target genes were further screened to perform functional enrichment and pathway enrichment analyses. Subsequently, 196 target genes of DGBXD were obtained from TCMSP, with six downregulated target genes and six upregulated target genes of DGBXD acting on IPF being identified. A promising miRNA-mRNA regulatory network of DGBXD acting on IPF was developed in this study. Moreover, mir-493 together with its target gene Olr1 and mir-338 together with Hif1a were further validated by qRT-PCR. Conclusion. This study proposed detailed possible processes of miRNA-mRNA modulatory axis in IPF and constructed a prospective IPF-related miRNA-mRNA modulatory network with the aim of alleviating IPF with DGBXD.

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Section: Introductionsupporting

confidence: 62%

Danggui Buxue Decoction Ameliorates Idiopathic Pulmonary Fibrosis through MicroRNA and Messenger RNA Regulatory Network

Zhang

Wang

Shi

et al. 2022

Evidence-Based Complementary and Alternative Medicine

Self Cite

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“…The research of Wu Q et al [61] showed that traditional Chinese medicine related treatment had advantages over simple western medicine in the treatment of IPF. Studies of Zhou M et al [52] and Zhang Y et al [62] further demonstrated that the traditional Chinese medicine of Nourishing Yin, supplementing qi and activating blood circulation was better than simple western medicine for IPF. However, the control treatment scheme and traditional Chinese medicine treatment scheme of these studies were not clear, and relevant subgroup analysis was not conducted.…”

Section: Plos Onementioning

confidence: 99%

Clinical efficacy of Chinese herbs for supplementing qi and activating blood circulation combined with N-acetylcysteine in the treatment of idiopathic pulmonary fibrosis: A systematic review and network meta-analysis

Pang

Cao

et al. 2022

PLoS ONE

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Background Chinese herbs for supplementing qi and activating blood circulation (CH) combined with N-acetylcysteine (NAC) is widely used for idiopathic pulmonary fibrosis (IPF) in China, but there is a lack of literature to evaluate its efficacy and clinical value. Purpose This study compared CH + NAC with other treatments by network meta-analysis to clarify its clinical value. Methods Cochrane Library, PubMed, Embase, Web of Science, China National Knowledge Infrastructure, WanFang Data, VIP Database, and China Biology Medicine were searched. Outcomes included lung function (DLCO (%), VC (%), FVC (%), FVC (L)), 6-min walking distance (6MWD), score of St George’s respiratory questionnaire (SGRQ), blood gas analysis (PaO2, PaCO2). The data were analyzed by Review Manager 5.4, Stata 12.0 and ADDIS 1.16.5. Results 23 studies including 1390 patients (702 in intervention group and 688 in control group) were collected to compare 8 outcome indicators among different treatments involving CH, CH+NAC, CH+PFD, NAC, PFD and PFD+NAC on IPF. Network meta-analysis showed that CH was better than NAC in terms of DLCO (%) (MD = 5.14, 95%CI: 1.01 to 8.68) and 6MWD (MD = 49.17, 95%CI: 25.97 to 71.36) as well as PFD + NAC was better than NAC in terms of FVC (L) (MD = -0.56, 95%CI: -0.83 to -0.31). In rankings results, CH + NAC is the best in terms of FVC (%), SGRQ, PaO2 and PaCO2; CH is the best in terms of DLCO (%), VC (%) and 6MWD; CH + PFD is the best in terms of FVC (L). Conclusion CH related treatments may have advantages in the treatment of IPF and CH + NAC may have clinical application value. However, limited by the quality and quantity of researches included, more rational and scientific randomized controlled trials containing large sample sizes need to be conducted to further verify our conclusions.

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“…The main functions of ASR include nourishing the blood, promoting blood circulation, regulating menstruation and analgesia, moisturizing and smoothing the intestines, and relieving abdominal pain due to cold deficiency and numb skin. Recent studies have also found that ASR can be used to treat idiopathic pulmonary fibrosis, 39 depression, 40 and multiple sclerosis. 41 It also has the effects of ameliorating memory deficiency 42 and promoting axon regeneration after ischemic brain injury, 43 as well as exerting antiinflammatory 44 and neuroprotective effects, 45 and promoting synaptic plasticity during cognitive recovery.…”

Section: Angelicae Sinensis Radix (Asr)mentioning

confidence: 99%

<p>Research Progress on Classical Traditional Chinese Medicine Jieyu Pills in the Treatment of Depression</p>

Wang¹,

Miao²

2020

NDT

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Radix Astragali and Radix Angelicae Sinensis in the Treatment of Idiopathic Pulmonary Fibrosis: A Systematic Review and Meta-analysis

Abstract: Conclusion: RA and RAS are effective and safe in the treatment of IPF, which is beneficial to pulmonary function and exercise tolerance of these patients.

Cited by 26 publications

References 52 publications

Danggui Buxue Decoction Ameliorates Idiopathic Pulmonary Fibrosis through MicroRNA and Messenger RNA Regulatory Network

Danggui Buxue Decoction Ameliorates Idiopathic Pulmonary Fibrosis through MicroRNA and Messenger RNA Regulatory Network

Clinical efficacy of Chinese herbs for supplementing qi and activating blood circulation combined with N-acetylcysteine in the treatment of idiopathic pulmonary fibrosis: A systematic review and network meta-analysis

<p>Research Progress on Classical Traditional Chinese Medicine Jieyu Pills in the Treatment of Depression</p>

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