Radium-induced malignant tumors of the mastoid and paranasal sinuses

Ms, Littman; Ie, Kirsh; At, Keane

doi:10.2214/ajr.131.5.773

Cited by 20 publications

(3 citation statements)

References 18 publications

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“…A review of publications in English (MEDLINE, 1966-2011) was performed, with all cases reported as MEC of the sinonasal tract included in the review [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. However, many cases were excluded if the lesion arose primarily in the oral cavity or parotid gland and extended into the sinonasal tract, or represented a different tumor type (hamartoma, squamous cell carcinoma, primary sinonasal tract adenocarcinoma), or if the information was too generalized and non-specific to make a meaningful interpretation of the demographics, histologic features, or patient outcome [8,9,11,13,[32][33][34][35][36][37][38][39][40][41].…”

Section: Methodsmentioning

confidence: 99%

Sinonasal Tract Mucoepidermoid Carcinoma: A Clinicopathologic and Immunophenotypic Study of 19 Cases Combined with a Comprehensive Review of the Literature

Wolfish

Nelson

Thompson

2011

Head and Neck Pathol

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Primary sinonasal tract mucoepidermoid carcinomas (MEC) are uncommon tumors that are frequently misclassified, resulting in inappropriate clinical management. The design of this study is retrospective. Nineteen cases of MEC included 10 females and 9 males, aged 15-75 years (mean, 52.7 years); males, on average were younger by a decade than females (47.2 vs. 57.7 years). Patients presented most frequently with a mass, obstructive symptoms, pain, and/or epistaxis present for a mean of 12.6 months. The majority of tumors involved the nasal cavity alone (n=10), maxillary sinus alone (n=6), or a combination of the nasal cavity and paranasal sinuses (n=3) with a mean size of 2.4 cm. Most patients presented at a low clinical stage (n=15, Stage I & II), with only 4 patients presenting with Stage III disease. Histologically, the tumors were often invasive (bone or perineural invasion), with invasion into minor mucoserous glands. Surface involvement was common. The neoplastic cells were composed of a combination of squamoid cells, intermediate cells, and mucocytes. Cystic spaces were occasionally large, but the majority were focal to small. Pleomorphism was generally low grade. Necrosis (n=5) and atypical mitotic figures (n=6) were seen infrequently. Over half of the tumors were classified as low grade (n=11), with intermediate (n=4) and high grade (n=4) comprising the remainder. Mucicarmine was positive in all cases tested. Immunohistochemical studies showed positive reactions for keratin, CK5/6, p63, CK7, EMA, and CEA in all cases tested, while bcl-2 and CD117 were rarely positive. GFAP, MSA, TTF-1, and S100 protein were non-reactive. p53 and Ki-67 were reactive to a variable degree. MEC need to be considered in the differential diagnosis of a number of sinonasal lesions, particularly adenocarcinoma and necrotizing sialometaplasia. The patients were separated into stage I (n=9), stage II (n=6), and stage III (n=4), without any patients in stage IV at presentation. Surgery occasionally accompanied by radiation therapy (n=2) was generally employed. Six patients developed a recurrence, with 5 patients dying with disease (mean, 2.4 years), while 14 patients are either alive (n=9) or had died (n=5) of unrelated causes (mean, 14.6 years). MEC probably arises from the minor mucoserous glands of the upper aerodigestive tract, usually presenting in patients in middle age with a mass. Most patients present with low stage disease (stage I and II), although invasive growth is common. Recurrences develop in about a third of patients, who experience a shorter survival (mean, 6.5 years). The following parameters, when present, suggest an increased incidence of recurrence or dying with disease: size ≥ 4.0 cm (P=0.034), high mitotic count (P=0.041), atypical mitoses (P=0.007), mixed anatomic site (P=0.032), development of recurrence (P=0.041), high tumor grade (P=0.007), and higher stage disease (P=0.027).

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Section: Methodsmentioning

confidence: 99%

Sinonasal Tract Mucoepidermoid Carcinoma: A Clinicopathologic and Immunophenotypic Study of 19 Cases Combined with a Comprehensive Review of the Literature

Wolfish

Nelson

Thompson

2011

Head and Neck Pathol

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“…En 1978, Littman et al ont identifié 11 cas de cancers des sinus paranasaux parmi 5 058 sujets ayant eu une exposition thérapeutique ou professionnelle (peintres de cadrans au radium) au radium. Les types histologiques rencontrés étaient : trois carcinomes épidermoïdes, quatre carcinomes muco-épidermoïdes, deux adénocarcinomes, un rhabdomyosarcome et un type histologique inconnu [82]. L'exposition au thorotrast ou dioxyde de thorium (suspension injectable contenant des particules radioactives), qui est un produit de contraste radiologique utilisé dans les années 1930 et 1940 puis abandonné dans les années 1950, a été incriminée également dans la genèse des cancers nasosinusiens [32,83].…”

Section: Radiations Ionisantesunclassified

Cancers des cavités nasales et des sinus paranasaux : aspects clinicopathologiques, étiologiques et thérapeutiques

Rhif

2012

Bulletin du Cancer

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“…6 The ingested 226 Ra primarily accumulated in bone and the watch dial painters had an increased risk of developing osteomyelitis, osteosarcomas, and head carcinomas of the mastoid and paranasal sinus. 7,8 The watch dial painter's studies were used in the development of a radium biokinetic model published by the International Commission on Radiological Protection (ICRP). 9 223 RaCl 2 is currently being used for the treatment of osteosarcoma.…”

Section: Introductionmentioning

confidence: 99%

Quadrupole and multi-collector ICP-MS analysis of ²²⁶Ra in brain from a radium dial painter

Arbova

Tolmachev

Brockman

2022

J. Anal. At. Spectrom.

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Radium-induced malignant tumors of the mastoid and paranasal sinuses

Cited by 20 publications

References 18 publications

Sinonasal Tract Mucoepidermoid Carcinoma: A Clinicopathologic and Immunophenotypic Study of 19 Cases Combined with a Comprehensive Review of the Literature

Sinonasal Tract Mucoepidermoid Carcinoma: A Clinicopathologic and Immunophenotypic Study of 19 Cases Combined with a Comprehensive Review of the Literature

Cancers des cavités nasales et des sinus paranasaux : aspects clinicopathologiques, étiologiques et thérapeutiques

Quadrupole and multi-collector ICP-MS analysis of ²²⁶Ra in brain from a radium dial painter

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Radium-induced malignant tumors of the mastoid and paranasal sinuses

Cited by 20 publications

References 18 publications

Sinonasal Tract Mucoepidermoid Carcinoma: A Clinicopathologic and Immunophenotypic Study of 19 Cases Combined with a Comprehensive Review of the Literature

Sinonasal Tract Mucoepidermoid Carcinoma: A Clinicopathologic and Immunophenotypic Study of 19 Cases Combined with a Comprehensive Review of the Literature

Cancers des cavités nasales et des sinus paranasaux : aspects clinicopathologiques, étiologiques et thérapeutiques

Quadrupole and multi-collector ICP-MS analysis of 226Ra in brain from a radium dial painter

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Quadrupole and multi-collector ICP-MS analysis of ²²⁶Ra in brain from a radium dial painter