Radiotracer Uptake in Medullary Carcinoma of the Thyroid

Parthasarathy, K. L.; Shimaoka, Katsutaro; Bakshi, Suraj P.; Razack, Mohamed S.

doi:10.1097/00003072-198002000-00001

Cited by 21 publications

(6 citation statements)

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“…Iodine and 99 mTc pertechnetate usually do not accumulate in MTC, even though a report described accumulation of 1311 and 99mTc pertechnetate in recurrent MTC masses. 3 The case presented in this report showed a cold area in 99 mTc pertechnetate scintigraphy. 1311 metaiodobenzyl-guanidine (131I MIBG) was reported to accumulate in MTC.…”

Section: Discussionmentioning

confidence: 63%

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Accumulation of thallium-201 in medullary thyroid cancer with negative serum calcitonin and carcinoembryonic antigens: A case report

1993

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Thallium-201 (201Tl) scintigraphy has been used in the evaluation of thyroid neoplasm. Even though several authors have shown the usefulness of 201Tl scintigraphy in evaluating recurrent tumor of medullary thyroid cancer, the number of reports on primary thyroid cancer is limited. We presented a case of medullary thyroid cancer which showed 201Tl uptake in both early and delayed scans. This case had normal serum levels of calcitonin and carcinoembryonic antigen.

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Section: Discussionmentioning

confidence: 63%

“…201fl accumulation in recurrent MTC has been reported by many authors. [3][4][5] However, few reports on primary MTC are available now. Senga et al reported first positive 201T1 uptake in one case,6 whereas Ochi et al reported a 201fl negative MTC case.…”

Section: Discussionmentioning

confidence: 99%

Accumulation of thallium-201 in medullary thyroid cancer with negative serum calcitonin and carcinoembryonic antigens: A case report

1993

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“…To the authors' knowledge, radionuclide uptake by a medullary carcinoma has only been described in 1 previous report in veterinary medicine. 12 In human medicine, trapping of radioiodine and 99m TcO 4 has been described, 26,27 According to a previous study, planar scintigraphy does not appear to offer any additional benefit, compared to thoracic radiography, for detection of pulmonary metastases. 12 In our study, only 2 of 29 dogs had radiographic evidence of pulmonary metastases, which is considerably lower than reported metastatic rates.…”

Section: Discussionmentioning

confidence: 99%

Planar and single‐photon emission computed tomography imaging in dogs with thyroid tumors: 68 cases

Berg

Daminet

Stock

et al. 2020

Veterinary Internal Medicne

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Background: Information on scintigraphy findings in dogs with thyroid neoplasia is scarce. The use of single-photon emission computed tomography (SPECT) could improve detection of metastatic disease. Hypothesis/Objectives: To describe planar and SPECT imaging findings in dogs with thyroid tumors, and to compare SPECT and thoracic radiography for metastasis detection. Animals: Sixty-eight dogs with thyroid neoplasia. Methods: Retrospective study, search of medical records for dogs with thyroid neoplasia (2008-2018). Results: Thyroid scintigraphy was available from 68 dogs, of which 6 presented after surgical resection. Radionuclide uptake was increased in 56% of dogs, decreased in 24%, and comparable to that of the salivary glands in 13%. The remainder had multiple masses with variable uptake. A homogeneous uptake pattern was present in 16% and a heterogeneous uptake pattern in 73%. In 11% (all dogs with multiple masses), various uptake patterns were present. Thyroid tumors were well delineated in 55%. There was a significant association between hormone status and uptake pattern (P = .009), with a heterogeneous uptake pattern in the majority of euthyroid dogs, and hormone status and tumor circumscription (P = .003), with well-circumscribed margins in the majority of hypothyroid and hyperthyroid dogs. Thoracic SPECT imaging was available in 39 dogs and identified metastatic lesions in 15 dogs. Thoracic radiographs were performed in 14 of these dogs, and detected metastases in 3 dogs.

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“…To the authors knowledge, there is only one previous report in veterinary medicine and very limited reports in human medicine of medullary carcinomas exhibiting iodine uptake [36], [44], [45]. The mechanism underlying the ability of medullary carcinoma cells to trap iodine remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Effect of Recombinant Human Thyrotropin on the Uptake of Radioactive Iodine (123I) in Dogs with Thyroid Tumors

et al. 2012

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In humans, recombinant human thyrotropin (rhTSH) enhances radioactive iodine uptake (RAIU) in patients with differentiated thyroid cancer. No studies have been performed in veterinary medicine to optimize radioiodine treatment of thyroid cancer. The aim of this study was to evaluate the effect of rhTSH on the uptake of radioiodine-123 (123I) in dogs with thyroid tumors. Nine dogs with thyroid neoplasia were included in this prospective cross-over study. The dogs were divided in 2 groups. In one group, 123I was administered for a baseline RAIU determination in week 1. In week 2 (after a washout period of 2 weeks), these dogs received rhTSH (100 μg IV) 24 h before 123I injection. In the other group the order of the protocol was reversed. For each scan, the dogs received 37 MBq (1 mCi) of 123I intravenously (IV) and planar scintigraphy was performed after 8 and 24 h for tumor RAIU calculation. Overall, rhTSH administration caused no statistically significant change on thyroid tumor RAIU at 8 h (p = 0.89) or at 24 h (p = 0.98). A significant positive correlation was found between the effect of rhTSH on tumor 8h-RAIU and rhTSH serum concentrations at 6 h (τ = 0.68; p = 0.03), at 12 h (τ = 0.68; p = 0.03) and at 24 h (τ = 0.78; p = 0.02) after rhTSH injection. This study suggests that IV administration of 100 μg rhTSH 24 h before 123I has an inconsistent effect on thyroid tumor RAIU. Further studies are necessary to determine the best protocol of rhTSH administration to optimize thyroid tumor RAIU.

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Radiotracer Uptake in Medullary Carcinoma of the Thyroid

Cited by 21 publications

References 0 publications

Accumulation of thallium-201 in medullary thyroid cancer with negative serum calcitonin and carcinoembryonic antigens: A case report

Accumulation of thallium-201 in medullary thyroid cancer with negative serum calcitonin and carcinoembryonic antigens: A case report

Planar and single‐photon emission computed tomography imaging in dogs with thyroid tumors: 68 cases

Effect of Recombinant Human Thyrotropin on the Uptake of Radioactive Iodine (123I) in Dogs with Thyroid Tumors

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