Radiotherapy treatment of keloid scars with a kilovoltage X-ray parallel pair

Eaton, D.; Barber, Elizabeth; Ferguson, Leila E.; Simpson, G M; Collis, C.

doi:10.1016/j.radonc.2011.08.002

Cited by 15 publications

(11 citation statements)

References 10 publications

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“…To date, X-ray still acts as an adjuvant role in new combination therapies. [3738] X-ray was generated by an electron-exciting device and customarily delivers superficial low-dose radiation toward the lesions. Originally, radiation therapists use 100–400 keV; however, low-energy X-ray resulted with more acute skin side effects.…”

Section: Different Radiations Keloids and Strategiesmentioning

confidence: 99%

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Radiation Therapy in Keloids Treatment

Yang

et al. 2017

Chinese Medical Journal

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Objective:Radiation therapy combined with surgical excision was considered as one of the most effective treatment plans for keloid lesions. However, there was no unanimity found over present literatures regarding the issue on optimized treatment strategy for keloids. We here provide a comprehensive review over this issue and emphasize on the influencing factors.Data Sources:The data analyzed in this review were searched from articles included in PubMed and EMBASE databases.Study Selection:The original articles and critical reviews discussing the application of radiation therapy in keloids treatment were selected for this review.Results:The application of radiation therapy has transitioned from simple superficial X-ray irradiation to brachytherapy. Furthermore, several factors including radiation type, dose, fraction, interval, and complications were reviewed, and the results revealed that these factors were significant toward clinical outcome at various levels.Conclusions:Both past and present evidence support the idea that combination therapy of radiation and surgical therapy is safe and feasible. However, the optimization of treatment strategy was based on different radiation types and should take dose, fractions, interval, and complications into consideration, which will then decrease the rate of recurrence and increase the level of satisfaction.

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Section: Different Radiations Keloids and Strategiesmentioning

confidence: 99%

“…Moreover, due to homogeneous earlobe sites, 60 kV and 120 kV beams achieved homogeneity of two separated but close lesions treatment, with the satisfaction rating of 4.7/5. [41]…”

Section: Different Radiations Keloids and Strategiesmentioning

confidence: 99%

Radiation Therapy in Keloids Treatment

Yang

et al. 2017

Chinese Medical Journal

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“…In clinical conditions, the depth of underlying material may be limited by lack of tissue (for example, treatment of keloids on the pinna of the ear (7) ) and BSF may be greatly reduced in these circumstances. Lead shielding is sometimes used behind the target volume, which can lead to both dose reduction from lack of underlying tissue and dose enhancement at short distances because of backscatter from the lead.…”

Section: Introductionmentioning

confidence: 99%

Review of backscatter measurement in kilovoltage radiotherapy using novel detectors and reduction from lack of underlying scattering material

Eaton

Doolan

2013

J Applied Clin Med Phys

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Lack of underlying material can lead to dose reduction in kilovoltage radiotherapy treatments because of backscatter reduction. Conversely, the use of lead shielding can lead to large dose enhancement close to the lead interface. GAFCHROMIC film has been shown to be of use in verification of local backscatter factors compared to reference data in codes of practice, but careful handling and multiple readings are required to reduce systematic uncertainties to between 3% and 4%. Monte Carlo modeling of the specific treatment unit should be performed in cases which are found to differ from reference values before alternative values are adopted clinically, but these cases are expected to be few. GAFCHROMIC film may also be used to estimate backscatter reduction more readily than customized ionization chambers, for a range of beam qualities, applicator sizes and depth, with and without lead shielding. Differences were found between different studies, and it is not clear to what extent these are due to variation in equipment and/or technique. However, a layer of wax around lead shielding of 1 mm thickness should be sufficient to eliminate lead enhancement effects for all kilovoltage energies from 40 kV to 300 kVPACS numbers: 87.55.Qr, 87.56.jk

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“…70,71 In a recent survey of non-melanoma skin cancer, 81% of respondents used kilovoltage therapy. 70 A retrospective analysis of 1715 lesions treated over 10 years (including the past 2 years with the SRT-100 unit) found 5-year recurrence rates of 4.2% for basal cell carcinoma (BCC) and 5.8% for squamous cell carcinoma (SCC) tumours.…”

Section: Clinical Applications Skinmentioning

confidence: 99%

Electronic brachytherapy—current status and future directions

Eaton¹

2015

BJR

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In the past decade, electronic brachytherapy (EB) has emerged as an attractive modality for the treatment of skin lesions and intraoperative partial breast irradiation, as well as finding wider applications in intracavitary and interstitial sites. These miniature X-ray sources, which operate at low kilovoltage energies (,100 kV), have reduced shielding requirements and inherent portability, therefore can be used outside the traditional realms of the radiotherapy department. However, steep dose gradients and increased sensitivity to inhomogeneities challenge accurate dosimetry. Secondly, ease of use does not mitigate the need for close involvement by medical physics experts and consultant oncologists. Finally, further studies are needed to relate the more heterogeneous dose distributions to clinical outcomes. With these provisos, the practical convenience of EB strongly suggests that it will become an established option for selected patients, not only in radiotherapy departments but also in a range of operating theatres and clinics around the world.

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Radiotherapy treatment of keloid scars with a kilovoltage X-ray parallel pair

Cited by 15 publications

References 10 publications

Radiation Therapy in Keloids Treatment

Radiation Therapy in Keloids Treatment

Review of backscatter measurement in kilovoltage radiotherapy using novel detectors and reduction from lack of underlying scattering material

Electronic brachytherapy—current status and future directions

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