Radiotherapy‐related arterial intima thickening and plaque formation in childhood cancer survivors detected with very‐high resolution ultrasound during young adulthood

Vatanen, Anu; Sarkola, Taisto; Ojala, Tiina; Turanlahti, Maila; Jahnukainen, Timo; Saarinen‐Pihkala, Ulla M.; Jahnukainen, Kirsi

doi:10.1002/pbc.25616

Cited by 42 publications

(68 citation statements)

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“…This is in agreement with two recent studies 16,17 Vatanen et al found increased carotid artery stiffness in the cohort of 19 high-risk neuroblastoma patients compared with the control group, no differences in stiffness parameters were observed when comparing total body RT with non-total body RT survivors, but the number of patients in the two groups was small. 17 Krystal et al evaluated carotid-femoral PWV in a cohort of 68 LTSCC, including non-irradiated patients, and healthy controls. LTSCC >18 years old at evaluation had significantly higher PWV compared to controls >18 years old and 70% of LTSCC >18 years had elevated PWV compared to established norms.…”

Section: Discussionsupporting

confidence: 81%

“…Many authors reported on higher incidence of atherosclerotic changes in patients treated with neck RT for head and neck cancers or HD in adulthood [7][8][9][10][11][12]24,25 , and in LTSCC who were treated with RT as well. [13][14][15]17 But to our knowledge this study is the first population based study of long-term survivors of HD after neck RT.…”

Section: Discussionmentioning

confidence: 99%

“…Namely, in our study there was no significant difference in IMT between the group of survivors and controls. Many authors offered IMT as a possible surrogate marker for stroke [14][15][16][17] , however there are In the second column controls are coded with 0 and cases with 1. AC = arterial compliance; AI = augmentation index; Ep = pressure-strain elastic modulus; IMT = intima-media thickness; PWV = pulse-wave velocity…”

Section: Discussionmentioning

confidence: 99%

“…This is in concordance with the report of Vatanen et al who described premature vascular aging (decreased ar- Brought to you by | MIT Libraries Authenticated Download Date | 5/13/18 9:47 AM terial lumen, arterial plaques and increased IMT) in adolescents and young adult survivors of neuroblastoma even after TBI of 10-12 Gy. 17 We analysed the influence of treatment with ChT inside the group of patients as well and there was no significant association between treatment with ChT and PWV or plaque deposits and/ or arterial wall calcinations. We were not able to sub-analyse the influence of ChT containing anthracyclines, because only 2 of our patients got it.…”

Section: Discussionmentioning

confidence: 99%

“…Arterial stiffness was proposed as a possible surrogate for cardiovascular morbidity in LTSCC. 17,18 However, the stiffness indices were not systematically studied. Therefore, we analysed indices of arterial stiffness besides intima-media thickness as possible early markers of later occurring stroke.…”

Section: Introductionmentioning

confidence: 99%

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Is carotid stiffness a possible surrogate for stroke in long-term survivors of childhood cancer after neck radiotherapy?

Zaletel¹,

Popit²,

Zaletel³

2018

Radiology and Oncology

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Disclosure: No potential conflicts of interest were disclosed.Background. The risk for cerebrovascular late effects among childhood cancer survivors is considerable. According to recent studies it is not clear which marker could be reliable for the screening of cerebrovascular diseases among the long-term survivors of childhood cancer. The purpose of this study is to analyse arterial stiffness and intima-media thickness as possible early markers of later occurring stroke in long-term survivors of childhood cancer after neck radiotherapy.Patients and methods. Twenty-three patients, treated for Hodgkin disease (HD) in childhood, were included.They had received radiation therapy to the neck with 20-65 (median 30) Gy. Twenty-six healthy controls, matched in age, sex, body mass index, arterial hypertension, smoking history and total cholesterol levels were compared. Highresolution colour-coded duplex sonography and power Doppler sonography of the carotid arteries were performed and intima-media thickness, number and quality of plaques were measured. Arterial stiffness indices were calculated.Results. Plaque deposits and/or arterial wall calcinations were found in 24 out of 43 (55.8%) irradiated vessels in cancer survivors group and 0 out of 52 vessels in the group of healthy controls (p < 0.01). We found significant group differences for all the stiffness parameters we used (P < 0.05), but there was no difference in intima-media thickness between cases and controls (p = 0.92). In a multivariate model, carotid pulse wave velocity was positively associated with smoking.Conclusions. The arterial stiffness has appeared as a possible surrogate marker for stroke in long-term survivors of childhood cancer. Smoking habit might have an additional negative influence on vascular aging in the group of patients after neck radiotherapy.

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Section: Discussionsupporting

confidence: 81%