Radiotherapy Planning

Truong, Minh Tam; Kovalchuk, Nataliya

doi:10.1016/j.cpet.2014.12.010

Cited by 5 publications

(4 citation statements)

References 97 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As EBRT techniques are constantly evolving and become more conformal with the increasing use of IMRT, whereby sharp dose gradients exist between the target and adjacent normal tissue, accurate contouring of tumor targets is very important in order to achieve cure and LR control; 18 F-FDG- positron emission tomography (PET) can provide more accurate target identification (46). It is well-known that many malignancies have higher metabolism and consequently an increased uptake of FDG than surrounding normal tissues.…”

Section: Clinical Target Volumesmentioning

confidence: 99%

“…In a study published in 2008, Azrif et al (45) followed 49 patients treated for DTC and found that the majority of recurrences in TC are LR in the lateral neck and thyroid bed. Based on the data reported in the literature, guidelines, and our institutional practice, we recommend the following policy: As EBRT techniques are constantly evolving and become more conformal with the increasing use of IMRT, whereby sharp dose gradients exist between the target and adjacent normal tissue, accurate contouring of tumor targets is very important in order to achieve cure and LR control; 18 F-FDGpositron emission tomography (PET) can provide more accurate target identification (46). It is well-known that many malignancies have higher metabolism and consequently an increased uptake of FDG than surrounding normal tissues.…”

Section: Differentiated Thyroid Carcinomamentioning

confidence: 99%

See 1 more Smart Citation

External Beam Radiotherapy in Thyroid Carcinoma: Clinical Review and Recommendations of the AIRO “Radioterapia Metabolica” Group

Mangoni

Gobitti

Autorino

et al. 2016

Tumori

View full text Add to dashboard Cite

The therapeutic approach to thyroid carcinoma usually involves surgery as initial treatment. The use of external beam radiotherapy (EBRT) is limited to high-risk patients and depends on clinical stage and histologic type. Different behavior patterns and degrees of aggressiveness of thyroid carcinomas require different management for differentiated, medullary, and anaplastic carcinoma. However, the role of EBRT is an issue of debate. Most clinical studies are retrospective and based on single-institution experiences. In this article, we review the main literature and give recommendations for the use of EBRT in thyroid carcinoma on behalf of the "Radioterapia Metabolica" Group of the Italian Radiation Oncology Association.

show abstract

Section: Clinical Target Volumesmentioning

confidence: 99%

Section: Differentiated Thyroid Carcinomamentioning

confidence: 99%

External Beam Radiotherapy in Thyroid Carcinoma: Clinical Review and Recommendations of the AIRO “Radioterapia Metabolica” Group

Mangoni

Gobitti

Autorino

et al. 2016

Tumori

View full text Add to dashboard Cite

show abstract

“…Furthermore, numerous auto and semi-autosegmentation tools have been developed to quantify tumor activity and therefore facilitate the delineation of lung cancer reducing the interobserver variation in the definition of the GTV [7]. However, to date, there is still no consensus on which auto-segmentation tool to use for the delineation of lung tumors [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

The impact of training and professional collaboration on the interobserver variation of lung cancer delineations: a multi-institutional study

et al. 2018

View full text Add to dashboard Cite

Background: To assess the impact of training and interprofessional collaboration on the interobserver variation in the delineation of the lung gross tumor volume (GTVp) and lymph node (GTVln). Material and methods: Eight target volume delineations courses were organized between 2008 and 2013. Specialists and trainees in radiation oncology were asked to delineate the GTVp and GTVln on four representative CT images of a patient diagnosed with lung cancer individually prior each course (baseline), together as group (interprofessional collaboration) and post-training. The mean delineated volume and local standard deviation (local SD) between the contours for each course group were calculated and compared with the expert delineations. Results: A total 410 delineations were evaluated. The average local SD was lowest for the interprofessional collaboration (GTVp ¼ 0.194 cm, GTVln ¼ 0.371 cm) followed by the post-training (GTVp ¼ 0.244 cm, GTVln ¼ 0.607 cm) and baseline delineations (GTVp ¼ 0.274 cm, GTVln: 0.718 cm). The mean delineated volume was smallest for the interprofessional (GTVp ¼ 4.93 cm 3 , GTVln ¼ 4.34 cm 3) followed by the post-training (GTVp ¼ 5.68 cm 3 , GTVln ¼ 5.47 cm 3) and baseline delineations (GTVp ¼ 6.65 cm 3 , GTVln ¼ 6.93 cm 3). All delineations were larger than the expert for both GTVp and GTVln (p < .001). Conclusion: Our findings indicate that image interpretational differences can lead to large interobserver variation particularly when delineating the GTVln. Interprofessional collaboration was found to have the greatest impact on reducing interobserver variation in the delineation of the GTVln. This highlights the need to develop a clinical workflow so as to ensure that difficult cases are reviewed routinely by a second radiation oncologist or radiologist so as to minimize the risk of geographical tumor miss and unnecessary irradiation to normal tissue.

show abstract

“…In the context of multimodal imaging, the relevance of deformable registration is limited as these methods will most likely stay in the domain of pure algorithmic applications from a current perspective. Still it is emerging as a powerful tool in image-guided and adaptive radiotherapy for compensation of organ motion and handling of anatomical changes in the course of treatment [101][102][103][104][105][106][107][108].…”

Section: Deformable Registrationmentioning

confidence: 99%