Radiotherapy of T1 glottic cancer with 6 MeV X rays

Three weeks radiotherapy for T1 glottic cancer: the Christie and Royal Marsden Hospital Experience

“…They reported local tumour control rates similar in all the energy groups. Akine et al in their series of T1 glottic cancer patients reported an 81% local control for 27 patients with AC involvement compared with 91% LC for 127 patients without AC involvement which was of borderline significance (P ¼ 0:06) [1]. As the analysis did not control for other treatment factors it is a moot point whether the increased failure rate with AC involvement was in fact the result of underdosing at the AC.…”

“…Reported local control rates for T1 glottic cancer treated with definitive radiotherapy vary between 80 and 95% [1,20,24,42,46] with surgical salvage increasing local control to 90-100%. The reasons for this wide variation have been attributed to a range of patient, tumour and treatment related factors; these are summarised in Table 3.…”

Partial laryngectomy as salvage surgery for radiation failures in T1–T2 laryngeal cancer

“…[3][4][5][6] Surgical salvage was historically considered to be possible only with total laryngectomy, because complications associated with partial resection of irradiated cartilage were very high, as reported by Leroux-Robert 7 in 1957. With the development of better technology in energy, dosimetry, planning, and quality control of radiation, the damage of irradiated tissues has diminished 8 ; nevertheless, surgeons' interest in conservative salvage surgery has not increased proportionally. Many reports of successful partial laryngectomy after radiation failure have been published, but most of the series involve a limited number of cases.…”

Primary Radiotherapy of Tl and T2 Glottic Carcinoma: Analysis of treatment results and prognostic factors in 223 patients

“…Impaired cord mobility has been described as a significant risk factor in several reports (10,15,17,19,23), and a subdivision of T2 tumours into a T2b group with impaired mobility has been proposed (2). Other tumour-related factors discussed are tumour size (21), involvement of the anterior commissure (7,8,15,20), and histologic grade (6,10,16,21).…”

“…Optimal treatment demands tumour control and preservation of laryngeal function. Radiotherapy offers the possibility of preservation of voice quality and local control rates between 80% to 95% and 65% to 85% for T1 and T2 tumours respectively (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). Factors related to tumour (6, 7, 10, 1 I, 13, 15, 19-21, 23), patient (15,21,23) and treatment (12, 14, 16-18, 22, 24-27), explaining the heterogeneity in treatment outcome, have been searched for, especially among T2 tumours.…”