Radiotherapy of salivary gland tumours

Larnaudie, A.; Marcy, Pierre-Yves; Delaby, N.; Martineau, Valérie Costes; Troussier, I.; Bensadoun, René-Jean; Vergez, S.; Vernat, S. Servagi; Thariat, Juliette

doi:10.1016/j.canrad.2021.08.012

Cited by 8 publications

(2 citation statements)

References 34 publications

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“…[33] According to the French Society of Radiotherapy and Oncology (SFRO), post-operative RT can be used in addition to incomplete resection margins also in relation to recurrent PA larger than 5 cm, or those which pose a significant risk to the facial nerve. [34] In cases where the PA presented as multimodular at the first recurrence, RT as an adjuvant therapy was strongly recommended. Indeed, it was demonstrated that patients presenting with a multinodular PA were significantly more likely to suffer from recurrence than those with a nonmultinodular recurrence.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Biomarkers in Determining the Recurrence of Pleomorphic Adenomas

Salzano¹,

Barone²,

Borriello³

et al. 2023

Preprint

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Background: The aim of this study has been to investigate if inflammatory biomarkers such as the systemic immune-inflammation index (SII), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) have any correlation with the recurrence of pleomorphic adenomas (PA) in patients afflicted by this disease. Methods: A retrospective multicentre study involving two Italian centres, the Maxillofacial Sur-gery at the Policlinico Federico II in Naples and the ENT and Maxillofacial Surgery at the IRCCS G. Pascale National Cancer Institute in Naples, has been performed. The study, involving 608 pa-tients who had received a diagnosis of PA, was conducted between January 2000 and January 2020. A Receiver Operating Characteristic (ROC) curve was used to calculate the optimal cut-off values for the SII, PLR and NLR. A linear regression model (LRM) and a non-linear logistic re-gression model (NLRM) were realized with respect to the NLR, PLR and SII. Results: The highest performance was achieved by the NLR (cut-off 2.960) with the AUC = 0.91, with an accuracy of 96.1%, sensitivity of 78.4% and specificity of 97.2%, PPV = 64.4% and NPV = 98.6%. The LRM and NLRM including all the haematological parameters did not increase the per-formance in terms of recurrence detection. Conclusion: The NLR is an excellent support tool in predicting the recurrence of PA with a cut-off of 2.960. It can be a good reference point for surgical decision-making and follow-up in clinical practice.

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Section: Discussionmentioning

confidence: 99%

Inflammatory Biomarkers in Determining the Recurrence of Pleomorphic Adenomas

Salzano¹,

Barone²,

Borriello³

et al. 2023

Preprint

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show abstract

“…It should be mentioned that radiotherapy is frequently needed for salivary malignancies, especially in tumors presenting stages T3-T4 and extra parotid invasions [14], and that radiotherapy has a place in the definitive or adjuvant management of skin cancers [15]. A number of the patients in the study suffered from these pathologies [1], and more light should be shed on whether radiotherapy was given to these patients as well.…”

mentioning

confidence: 99%