Radiotherapy of extraosseous nasopharyngeal chordoma: A case report and literature review

Yeh, Chi-Yuan

doi:10.3892/mco.2021.2246

Cited by 4 publications

(5 citation statements)

References 31 publications

(62 reference statements)

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“…3 Local recurrence with an incidence of 50-68% is common due to the aggressive nature of this tumor, and systemic metastasis to the lung, bone, liver, and lymph nodes are found in 17.8-43% of patients with chordoma. 1 Adverse prognostic factors include subtotal resection, dedifferentiated histological subtype, age >40 years, history of prior treatment, tumor size ≥4cm, gross tumor volume >25cm 3 , pharyngeal involvement, optic nerve and brain stem compression, none or low-dose radiation therapy, and female sex. 1 Surgery is the primary modality to achieve the best longterm control.…”

Section: Discussionmentioning

confidence: 99%

“…1 Adverse prognostic factors include subtotal resection, dedifferentiated histological subtype, age >40 years, history of prior treatment, tumor size ≥4cm, gross tumor volume >25cm 3 , pharyngeal involvement, optic nerve and brain stem compression, none or low-dose radiation therapy, and female sex. 1 Surgery is the primary modality to achieve the best longterm control.…”

Section: Discussionmentioning

confidence: 99%

“…They account for 1-4% of all primary malignant bone tumors, with an incidence rate of 0.8 per 100,000 per year. 1 They occur twice as frequently in men compared to women, with an age range around 40-60 years. 2 The sacrococcygeal area (65%) is the most common site, followed by the spheno-occipital area (25%), and rarely the cervico-thoracolumbar spine (15%) is involved.…”

Section: Introductionmentioning

confidence: 99%

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Chondroid chordoma of the nasopharynx - A rare case report

Ghunawat,

Sonawane,

Godbole

et al. 2023

JDPO

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Chordomas are slow-growing tumors that account for 1-4% of all bone tumors. They are most commonly seen in the sacrum, followed by the base of the skull and spine. Males are affected more than females. A 28-year-old female presented with nasal bleeding and bilateral nasal obstruction for 1 month. Clinical, physical, and radiological examinations revealed a mass in the nasopharynx. The radiological diagnosis was a large polypoidal adenomatous neoplastic mass. However, histopathological examination revealed a chordoma. The nasopharynx is an unusual site for chordoma presentation, and it has a nonspecific clinical and radiological appearance. Hence, it should be considered as a differential diagnosis of a nasopharyngeal mass.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chondroid chordoma of the nasopharynx - A rare case report

Ghunawat,

Sonawane,

Godbole

et al. 2023

JDPO

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“…Chordoma arising from notochordal remnants is a relatively rare malignant neoplasm that accounts for 3-4% of all primary bone tumors [1]. The anatomical distribution of chordoma consists mainly of the sacrococcygeal area (55%), the spine region (10%), and the skull area (35%) [2].…”

Section: Introductionmentioning

confidence: 99%

Competing risk nomogram for predicting prognosis of patients with spinal and pelvic chordoma: A SEER-based retrospective study

Yuan

et al. 2023

Eur Spine J

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Purpose Recently, competing risk nomograms were widely applied to predict prognosis in numerous tumors other than chordoma. Here, we aimed to construct and validate a competing-risk-based prognostic nomogram to predict 3- and 5-year cancer-specific death (CSD) in patients with spinal and pelvic chordoma. Methods All chordoma patient data were abstracted from the Surveillance, Epidemiology, and End Results (SEER) resource, and a total of 485 chordoma patients were eventually included in this study. Multivariate competing risk model and multivariate Cox model were used to determine independent prognostic factors, respectively, and the results of the two models were compared. Nomogram was employed to visualize the competing risk model. The discrimination, calibration, and clinical utility of this model were evaluated by Harrell concordance index (C-index), time-dependent receiver operating characteristic (ROC) curves, calibration plots, and decision curve analysis (DCA). Ten-fold cross-validation was further utilized to validate the prognostic nomogram. Results Significant prognostic factors affecting CSD were age (P = 0.016), localized involvement (P < 0.0001), and radical resection (P < 0.001) in the multivariate competing risk model. C-indexes were 0.799 and 0.76, and AUC were 0.812 and 0.778 for 3- and 5-year CSD. Calibration plots demonstrated the nomogram was well-fitted, and DCA indicated good clinical utility. The nomogram showed good performance in the 10-fold cross-validation. Conclusion We successfully built the first competing-risk-based nomogram to predict clinical outcomes in patients with spinal and pelvic chordoma. This well-established nomogram hopes to help clinicians with precise prognostic assessment and thus improve clinical outcomes.

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“…Chordomas are rare malignant bone tumors originating from embryonic remnants of the notochord and account for approximately 1-4% of all primary bone malignancies [ 1 ]. These slow-growing neoplasms predominantly affect the axial skeleton, with approximately 50-60% of tumors occurring in the sacrococcygeal region [ 2 ]. Patients with sacral chordomas often present with insidious, nonspecific symptoms caused by the compression and/or destruction of adjacent structures by the tumor [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Sacral Chordoma Presenting as Back Pain in the Chiropractic Clinic: A Case Report

Chan¹,

Ng²,

Cheong³

et al. 2023

Cureus

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Cases of lumbar and gluteal pain are commonly encountered in chiropractic clinics, with a broad differential diagnosis primarily centered on musculoskeletal conditions. This report presents the second documented case of sacral chordoma diagnosed at a chiropractic clinic and emphasizes the importance of considering alternative diagnoses and interdisciplinary collaboration in patient care. A 42-year-old man presented to a chiropractic clinic with complaints of lumbar and gluteal pain. The initial conservative management based on a presumptive musculoskeletal diagnosis was ineffective. Suspicion of an alternative etiology prompted a referral for imaging, which revealed a sacral chordoma. An interdisciplinary collaboration involving orthopedic surgeons, oncologists, radiologists, and other healthcare professionals was initiated to optimize the treatment outcomes of this rare and aggressive tumor. This case report underscores the importance of maintaining a high index of suspicion in cases of musculoskeletal presentations in chiropractic clinics and the critical role of advanced imaging in establishing a definitive diagnosis. Interdisciplinary collaboration is essential for managing complex conditions such as sacral chordomas, ensuring the delivery of the highest quality of care, and optimizing patient outcomes. Chiropractors play a crucial role in identifying, referring, and contributing to the management of patients with complex presentations as part of a comprehensive multidisciplinary treatment plan.

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Radiotherapy of extraosseous nasopharyngeal chordoma: A case report and literature review

Cited by 4 publications

References 31 publications

Chondroid chordoma of the nasopharynx - A rare case report

Chondroid chordoma of the nasopharynx - A rare case report

Competing risk nomogram for predicting prognosis of patients with spinal and pelvic chordoma: A SEER-based retrospective study

Sacral Chordoma Presenting as Back Pain in the Chiropractic Clinic: A Case Report

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