Radiotherapy of cancer of the larynx

Lederman, M.

doi:10.1017/s0022215100072650

Cited by 108 publications

(49 citation statements)

References 5 publications

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“…Stewart et al 21 (72%) and Boles and Komorn 22 (74%) had lower 5-year cure rates. Lederman,23 in a large series of patients (n ‫ס‬ 137), had a 65% cure rate for T2N0M0 disease. Bilateral vocal cord involvement reduced the cure rate by 8%.…”

Section: Discussionmentioning

confidence: 98%

Management of stage II (T2N0M0) glottic carcinoma by radiotherapy and conservation surgery

Spector¹,

Sessions²,

Chao

et al. 1999

Head Neck

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Section: Discussionmentioning

confidence: 98%

Management of stage II (T2N0M0) glottic carcinoma by radiotherapy and conservation surgery

Spector¹,

Sessions²,

Chao

et al. 1999

Head Neck

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“…The upper limit of the subglottis has been a subject of controversy. Some authors [20,11] have considered the under-surface of the vocal cords as included in the subglottis; others [15] have excluded it. Bryce [3] pointed to the importance of the elastic cone in defining the superior portion of the subglottis: the elastic cone extends from the upper margin of the cricoid to the vocal ligaments of the vocal cords.…”

Section: Introductionmentioning

confidence: 99%

“…Despite the diagnosis of subglottic cancer in an advanced stage and with a rich lymphatic network, the incidence of cervical node metastasis at presentation reported in the literature is low [11,13]. Nevertheless, Harrison [6] demonstrated that 50% of occult metastases to the paratracheal nodes are undetectable clinically or by radiological examination.…”

Section: Introductionmentioning

confidence: 99%

Primary carcinoma of the subglottic larynx

Santoro

Turelli

Polli

2000

European Archives of Oto-Rhino-Laryngology

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Primary cancer of the subglottic region is very rare and delay in diagnosis often leads to a poor prognosis. We retrospectively reviewed 49 patients with primary cancer of the subglottic larynx observed from 1969 to 1993 in the ORL Clinic of the University of Florence. This number constitutes 1.6% of all laryngeal cancers observed during this period. Four (8.2%) patients were stage T1, 13 (26.5%) T2, 27 (55.1%) T3, and 5 (10.2%) T4. Forty-one patients were eligible for assessing the disease-free five-year survival rate, 17 of whom were treated with surgery alone, 6 with radiotherapy alone and 18 with combination therapy (surgery for the primary tumor and postoperative radiotherapy for cervical nodes). The five-year survival rate for the three treatment types was 47%, 0% and 83.3%, respectively. The overall survival rate was 56.1%. Combination therapy produced a significantly higher (P = 0.001) disease-free survival than surgery alone or radiotherapy alone.

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“…Some died of intercurrent disease without clinical evidence of active disease; some died of distant metastases. T h e end points used for evaluation were 2-year local control of primary site and neck nodes, and the absolute and determinate 5-year sur- 10.0 x 7.0 cm, and were designed to cover the primary site and primary draining nodes. Almost all patients treated with radiation therapy only, when not part of a planned preoperative course of irradiation, received 6000 rads.…”

Section: Methodsmentioning

confidence: 99%

Role of radiation therapy in the treatment of supraglottic carcinoma

Deffebach

Phillips

1972

Cancer

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One hundred and one cases of early and late supraglottic tumors covering a period of 22 years have been evaluated. The early stages, without lymph node metastasis, show a 75% 2‐year control and a 50% 5‐year survival. The local control rate is 75% in those patients treated at a dose equivalent to more than 1700 rets. More advanced supraglottic tumors with lymph node metastasis have shown a 15% 2‐year control rate, 10% 5‐year survival when treated with irradiation alone. We are now treating the more advanced tumors with clinical adenopathy with a course of preoperative irradiation of 4000 to 5500 rads in 5 to 6 1/2 weeks followed at an appropriate interval in all cases with radical surgical removal of the primary and draining node areas. Conservation surgery is being considered in the advanced cases as an alternative to total laryngectomy. Lesions without clinical nodes in the supraglottic area should be treated by radiation therapy alone. At least 6000 rads in 6 1/2 weeks should be delivered to the primary and node‐draining areas. Conservation surgery in these earlier cases can be reserved for radiation treatment failures, thus sparing the voice in 75% or more of the cured patients.

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Radiotherapy of cancer of the larynx

Cited by 108 publications

References 5 publications

Management of stage II (T2N0M0) glottic carcinoma by radiotherapy and conservation surgery

Management of stage II (T2N0M0) glottic carcinoma by radiotherapy and conservation surgery

Primary carcinoma of the subglottic larynx

Role of radiation therapy in the treatment of supraglottic carcinoma

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