Radiotherapy-induced “solar” comedones

Huang, Ching-Feng; Wang, Weiming

doi:10.1503/cmaj.112098

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…Loss of supporting properties of the dermis induces distension of the infundibular canal within sebaceous follicles, thus causing the onset of comedones (1,5). Similar changes can be detected after radiotherapy (6).…”

Section: Hyperpigmented Plaque On a Farmer's Nose: A Quizmentioning

confidence: 74%

Hyperpigmented Plaque on a Farmer’s Nose: A Quiz

Liu

Ma²,

Ma³

2019

Acta Derm Venerol

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A 66-year-old man presented with a 1-year history of asymptomatic hyperpigmented plaque on his apex nasi. The lesion initially appeared as erythematous macules, and several open, black comedones gradually developed. The patient was a farmer and had worked outdoors for more than 40 years without sun protection, which resulted in substantial sun exposure. He also had smoked >10 cigarettes daily for more than 40 years. On physical examination, a 1.5×2-cm hyperpigmented plaque was located on the apex nasi; it showed symmetrical distribution of multiple open, black comedones ( Fig. 1A). Wrinkles and furrows were present on the patient's forehead. The remainder of his physical examination was unremarkable. Laboratory tests were negative, including complete blood count, antinuclear antibodies, and dsDNA antibodies. A lesional punch biopsy showed epidermal atrophy, solar elastosis, and multiple dilated follicular infundibula filled with laminated keratinous material (Fig. 1B). Focal elastosis and degeneration of elastic fibres were observed in the dermis (Fig. 1C). Fig. 1. (A) Clinical image. A hyperpigmented plaque with multiple open, black comedones on the apex nasi. (B) Histopathological image. A lesional punch biopsy showed epidermal atrophy, solar elastosis, and multiple dilated follicular infundibula filled with laminated keratinous material (haematoxylineosin staining ×40). (C) Special stain image. Focal elastosis and degeneration of elastic fibres were observed in the dermis (elastic fibre staining ×40).

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Section: Hyperpigmented Plaque On a Farmer's Nose: A Quizmentioning

confidence: 74%

Hyperpigmented Plaque on a Farmer’s Nose: A Quiz

Liu

Ma²,

Ma³

2019

Acta Derm Venerol

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“…between 2 weeks and 6 months following radiation therapy. 1 Proper clinical and histopathological examination is needed in selected cases to rule out differentials like comedonal naevus, Favré-Racouchot syndrome and acne vulgaris.…”

Section: Declaration Of Patient Consentmentioning

confidence: 99%

Acneiform eruption secondary to radiotherapy

Liu

2021

Indian J Dermatol Venereol Leprol

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Acneiform eruption secondary to radiotherapyA 45-year-old man presented with T3N0M0 squamous cell carcinoma of the right tonsil. He underwent surgical therapy and megavoltage radiation therapy (70 Gy in 35 fractions). He developed several open and closed comedones along with some tender inflammatory papules over the irradiated area on both sides of his cheeks and neck, two months post radiotherapy. [Figure 1]. Lesional biopsy from neck demonstrated horn plugs blocking the hair follicles. A diagnosis of acneiform eruption secondary to radiotherapy was made. Topical tretinoin cream and oral isotretinoin (10 mg twice daily) were prescribed leading to rapid improvement within 4 weeks. Acneiform eruption with comedones is a late sequelae of radiation therapy which may develop Figure 1: Open and closed comedones along with tender inflammatory papules in the irradiated area on the right side of his cheeks and neck

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Favre−Racouchot disease: protective effect of solar elastosis

Yeh

Schwartz

2021

Arch Dermatol Res

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Radiotherapy-induced “solar” comedones

Cited by 3 publications

References 4 publications

Hyperpigmented Plaque on a Farmer’s Nose: A Quiz

Hyperpigmented Plaque on a Farmer’s Nose: A Quiz

Acneiform eruption secondary to radiotherapy

Favre−Racouchot disease: protective effect of solar elastosis

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