Radiotherapy-induced morphoea of the breast responding to photodynamic therapy

Abstract

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Radiation‐induced morphea of the breast—A case series

“…These options include: antibiotics (oral or systemic), steroids (topical, intralesional or systemic), light therapy (Ultraviolet A), other topical agents (e.g. hyaluronidase, calcipotriol), other systemic agents, photodynamic therapy (PDT), and in rare cases, surgical intervention 1,5,6,8,9 . Alternative steroid‐sparing agents used for managing RIM include: methotrexate, colchicine, azathioprine, cyclophosphamide, cyclosporin, tofacitinib, acitretin, mycophenolate or plasmaphaeresis 1,5,6 .…”

“…5 There are multiple treatment options available for RIM, ranging from topical to systemic and interventional. 7,8 The treatment approach is similar to that of idiopathic morphea. 3,5 These options include: antibiotics (oral or systemic), steroids (topical, intralesional or systemic), light therapy (Ultraviolet A), other topical agents (e.g.…”

“…hyaluronidase, calcipotriol), other systemic agents, photodynamic therapy (PDT), and in rare cases, surgical intervention. 1 , 5 , 6 , 8 , 9 Alternative steroid‐sparing agents used for managing RIM include: methotrexate, colchicine, azathioprine, cyclophosphamide, cyclosporin, tofacitinib, acitretin, mycophenolate or plasmaphaeresis. 1 , 5 , 6 Psoralen‐and‐ultraviolet‐light‐A (PUVA) in particular has been found to have excellent results with reduced inflammation and improved skin texture.…”

Radiation-induced morphea—a rare but severe late effect of adjuvant breast irradiation

“…(2018) [ 23 ] 1 5 months Not recorded Papanikolaou et al. (2018) [ 27 ] 1 4 months Not recorded Partl et al. (current report) 1 3 months Anastrozole, CDK4/6 inhibitor (abemaciclib) …”

“…For symptomatic improvement of the fibrosis, some authors recommend local application of heparin, hyaluronidase [ 25 ], ultraviolet A irradiation [ 26 ] or penicillin (3 × 10 6 IU daily for two weeks). In another case report photodynamic therapy is suggested as a successful treatment option [ 27 ]. Testing of the different therapy options in the largest RIM cohorts to date showed the best response to systemic treatment with MTX or ultraviolet-B phototherapy [ 28 ].…”