Radiotherapy-induced glioblastoma: distinct differences in overall survival, tumor location, pMGMT methylation and primary tumor epidemiology in Hong Kong chinese patients

Woo, Peter Yat Ming; Lee, Jennifer W Y; Lam, S.S.; Pu, Jenny Kan-Suen; Chan, Danny Tat Ming; Mak, Calvin Hoi Kwan; Ho, Jason M K; Wong, Sui-To; Po, Yin-Chung; Lee, Michael W.Y.; Chan, Kwong‐Yau; Poon, Wai-sang

doi:10.1080/02688697.2021.1881445

Cited by 2 publications

(2 citation statements)

References 46 publications

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“… 19 , 22 , 25 , 28 , 40 , 46 (B) Scatter plot of latency intervals for RIGs arising in the three defined brain regions. 18 , 19 , 22 , 23 , 25–32 , 34–38 , 40–42 , 45–48 , 50 Bars show mean ± SD.…”

Section: Resultsmentioning

confidence: 99%

“…Historically, RIGs have been clinically diagnosed as diffuse intrinsic pontine glioma (DIPG), 19 , 40 anaplastic astrocytoma (AA), 24 , 30 , 31 , 36–38 , 41 , 46 , 47 , 63 or GBM 22–25 , 28 , 29 , 34 , 38 , 39 , 41 , 42 , 45 , 46 , 48 , 50 based primarily on histological and/or radiographical characteristics. In very rare cases, the diagnosis of anaplastic ependymoma has also been reported.…”

Section: Discussionmentioning

confidence: 99%

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Defining the molecular features of radiation-induced glioma: A systematic review and meta-analysis

Whitehouse

Howlett

Federico

et al. 2021

Neuro-Oncology Advances

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Background Cranial radiation therapy is essential in treating many pediatric cancers, especially brain tumors, however its use comes with the risk of developing second malignancies. Cranial radiation-induced gliomas (RIGs) are aggressive high-grade tumors with a dismal prognosis, for which no standard therapy exists. A definitive molecular signature for RIGs has not yet been established. We sought to address this gap by performing a systematic review and meta-analysis of the molecular features of cranial RIGs. Methods A systematic review of the literature was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. English language articles and case reports referring to radiation-induced high-grade gliomas located in the human brain that included molecular analyses were identified, evaluated and data extracted for collation. Results Of 1727 records identified, 31 were eligible, containing 102 unique RIGs with molecular data. The most frequent genetic alterations in RIGs included PDGFRA or TP53 mutations, PDGFRA or CDK4 amplifications, and CDKN2A deletion, along with 1q gain, 1p loss and 13q loss. Of note, mutations in ACVR1, EGFR, H3F3A, HIST1H3B, HIST1H3C, IDH2, SMARCB1 or the TERT promoter were not observed. A comparative analysis revealed that RIGs are molecularly distinct from most other astrocytomas and gliomas and instead align most closely with the pedGBM_RTK1 subgroup of pediatric glioblastoma. Conclusions This comprehensive analysis highlights the major molecular features of RIGs, demonstrates their molecular distinction from many other astrocytomas and gliomas, and reveals potential genetic drivers and therapeutic targets for this currently fatal disease.

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