Radiotherapy-induced depigmentation in a patient with breast cancer

Munshi, Anusheel; Jain, Sandeep; Budrukkar, Ashwini; Jalali, Rakesh; Sarin, Rajiv

doi:10.4103/0019-509x.39379

Cited by 14 publications

(20 citation statements)

References 9 publications

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“…A Munshi et al, had reported a case of lady who was already having vitiligo in her lips and hands [4]. She was treated with radiotherapy to her chest wall and draining lymph nodes after she had undergone modified radical mastectomy for breast cancer.…”

Section: Discussionmentioning

confidence: 99%

“…The above mentioned case reports [3][4][5][6] had patients with preexisting vitiligo. Patients with prior history of vitiligo have increased risk of developing depigmentation in the radiotherapy portal area.…”

Section: Discussionmentioning

confidence: 99%

“…This is probably due to increased radiosensitivity of melanocytes in this disorder. The early cell death of melanocytes in vitiligo is because of their increased sensitivity to the oxidative stress caused by radiotherapy [4][5].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Radiotherapy-Induced Vitiligo in a Patient with Carcinoma Buccal Mucosa: A Case Report

Choudhary

2015

JCDR

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Radiotherapy-Induced Vitiligo in a Patient with Carcinoma Buccal Mucosa: A Case Report

Choudhary

2015

JCDR

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“…Association of this depigmentation disorder with irradiation has rarely been reported in the literature. [2,3] We report a rare case of radiation induced, generalized depigmentation, in a breast cancer patient, who had no history of vitiligo [ Figure 1]. We further discuss the possible etiopathological mechanisms of radiation induced, generalized vitiligo.…”

Section: Introductionmentioning

confidence: 93%

“…[1,2] Vitiligo does not have predilection for age, gender or ethnic background and is probably multifactorial in origin -involving genetic, autoimmune, neurologic, and metabolic factors. Association of this depigmentation disorder with irradiation has rarely been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

Generalized vitiligo post radiotherapy in a breast cancer patient

Vajrala¹,

Jain²,

Surana³

et al. 2014

J Can Res Ther

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Vitiligo is a common depigmentation disorder of skin, etiology of which is poorly understood. It has been rarely reported as a consequence of radiation at the site of irradiation, more so in patients with prior history of vitiligo. We report a rare clinical vignette that documents radiation-induced skin depigmentation, which started at the irradiated site and later manifested as generalized vitiligo, in a breast cancer patient with no family history of vitiligo. Studies describing the relationship between skin depigmentation and radiotherapeutic dose are scanty. The possible etiopathological mechanisms of vitiligo and radiation as a potential triggering factor for its development, which has been described in the literature, have been highlighted in this article.

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Cutaneous Side Effects of Chemotherapy and Radiotherapy

Fearfield

Natkunarajah

2016

Rook's Textbook of Dermatology, Ninth Edition

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Chemotherapy drugs are a well‐recognized cause of iatrogenic injury to the skin. Antineoplastic agents generally target rapidly dividing cells and are toxic to organ systems with high proliferative activity, including the skin and its appendages. These adverse effects include toxic erythema, alopecia, hyperpigmentation, nail changes, photosensitivity and papulopustular eruptions. Recently, the emergence of novel targeted agents has led to new patterns of cutaneous toxicity. Occasionally, severe chemotherapy reactions occur, necessitating cessation of the drug, however most dermatoses can be managed by simple measures allowing patients to continue essential anticancer treatment. Radiotherapy‐associated skin side effects are common and can be divided into those occurring early (days to weeks) during the treatment and those occurring late (months to years). Most reactions are due to radiation‐induced dermatitis and are limited to the treated area, however rare skin side effects can occur distant from the radiotherapy‐treated zone.

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Radiotherapy-induced depigmentation in a patient with breast cancer

Cited by 14 publications

References 9 publications

Radiotherapy-Induced Vitiligo in a Patient with Carcinoma Buccal Mucosa: A Case Report

Radiotherapy-Induced Vitiligo in a Patient with Carcinoma Buccal Mucosa: A Case Report

Generalized vitiligo post radiotherapy in a breast cancer patient

Cutaneous Side Effects of Chemotherapy and Radiotherapy

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