Radiotherapy in testicular germ cell tumours – a literature review

Jońska-Gmyrek, Joanna; Pęczkowski, Piotr; Michalski, Wojciech; Poniatowska, Grażyna; Żółciak-Siwińska, Agnieszka; Kotowicz, Beata; Wiechno, Paweł; Golawska, Magdalena; Kowalska, M; Demkow, Tomasz

doi:10.5114/wo.2017.69592

Cited by 12 publications

(11 citation statements)

References 34 publications

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“…Taking CS into consideration, PORT showed no advantage in reducing the risk of CSM in each CS. Based on previous studies and improvement of multi-modal management regimens, current utilization of radiotherapy may have come to a crossroad, adjustment has become a challenge for urologists and oncologists [7].…”

Section: Discussionmentioning

confidence: 99%

“…Most patients with TS can be cured with orchiectomy and, if necessary, subsequent chemotherapy or Post-Operative Radiotherapy (PORT) [1]. Although accurate diagnosis and advanced multimodal treatment significantly contribute to good prognosis, controversies regarding various side effects of PORT for the treatment of TS and its efficacy on patients' long term survival still exists [1,[3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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Evaluating the Effect of Post-Operative Radiotherapy on Long Term Survival of Testicular Seminomas: A Population Based Study

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et al. 2021

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Objectives: To assess the effect of post-operative radiotherapy (PORT) on long term survival in Testicular Seminoma (TS) patients and factors may effect the prognosis of PORT patients. Results: 12957 patients with a median age of 36.00 (13.00-107.00) years were pathologically diagnosed as primary TS. PORT was performed in 3407 patients. Patients with clinical stages I, II, and III testicular cancer accounted for 70.69% (n=9159), 8.30% (n=1075), and 5.72% (n=741) of all patients, respectively. According to results of multivariate Cox proportional hazard model, lower risk of cancer specific mortality was related with PORT in all patients (HR=0.40 95% CI=0.25-0.63 p<0.0001). However, no benefit in survival (p>0.05) was brought by PORT in either clinical stage. Aging, elevated human chorionic gonadotropin and lactate dehydrogenase level were related with higher risk of cancer specific mortality in PORT patients (p>0.05). Furthermore, aging and elevated LDH were inversely related with the prognosis of CSI PORT patients. No significant risk factor was observed in CSII and III PORT patients. Conclusion: PORT can be benefit to the long term survival in TS patients, however, it did not show significant advantage in patients of either clinical stage based on the results of our study. Elevation of human chorionic gonadotropin and lactate dehydrogenase levels and elder age related with higher risk of CSM in PORT patients. Utilization of PORT in the management of TS should be considered comprehensively.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluating the Effect of Post-Operative Radiotherapy on Long Term Survival of Testicular Seminomas: A Population Based Study

X¹,

Q²,

M³

et al. 2021

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“…26 Radiation remains one of the preferred treatment approaches for early stage seminoma even in the modern era. 27 Traditionally, radiation portals encompassed the para-aortic, ipsilateral iliac and obturator nodes in a 'dog-leg' (DL) field to a dose of 30Gy. Although local control rates were excellent, long term data provided concern regarding late sequelae.…”

Section: Discussionmentioning

confidence: 99%

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2018

IJRRT

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Background: Germ cell tumours (GCTs) are the most common cancer in young men, typically arising from the testes. However, a small subset (1% to 2%) appears to originate in other locations and is referred to as primary extragonadal germ cell tumors (EGCTs but origin remains controversial. New thought is that these so called primary retroperitoneal seminomas uniformly represent metastases from an occult or regressed testicular primary tumour. Method:We present case report of retroperitoneal seminoma in a 60 year old male patient who presented with bloody diarrhea. Endoscopic visualization of colon was normal but imaging confirmed incidental finding of a nodal mass in the abdomen. Biopsy report confirmed classic seminoma. A gonadal primary was not seen on testicular ultrasound. Staging imaging and PET did not identify any other sites of disease. Conclusion:Our case confirms the excellent response to radiation as monotherapy in retroperitoneal seminoma with no known primary. In order to understand this rare neoplasm and serve our patients well more emphasis should be on research for developing novel immunohistochemistry and markers. Citation: Koul R, Alshafa F, Tai P, et al. Successful treatment of incidentally diagnosed retroperitoneal seminoma with primary external beam radiotherapy. Int J Radiol Radiat Ther. 2018;5(2):69-74.

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“…There have been many advances in technologies underpinning the delivery of radiotherapy, including intensity-modulated radiotherapy (IMRT), volumetric-modulated arc therapy (VMAT), and proton therapy (PT). There are case reports that suggest, for example, that IMRT can lead to a reduction in acute affects [41], and there is initial evidence that VMAT also reduces acute affects with PT reducing the risk of secondary malignancies in younger patients [42]. However, robust and largescale clinical trial evidence is lacking in this area, and hence accurate survey and meta-analysis studies are not yet possible.…”

Section: Radiotherapy To the Testismentioning

confidence: 99%