Radiotherapy in conjunction with intravenous infusion of 180 mg of disodium pamidronate in management of osteolytic metastases from breast cancer: Clinical evaluation, biochemical markers, quality of life, and monitoring of recalcification using assessments of gray-level histogram in plain radiographs

Kouloulias, Vassilis; Matsopoulos, George K.; Kouvaris, John; Dardoufas, C.; Bottomley, Andrew; Varela, Maria; Uzunoglu, N.K.; Antypas, Christos; Metafa, Anna; Moulopoulos, Lia A.; Sandilos, P.; Vlahos, Lambros

doi:10.1016/s0360-3016(03)00525-x

Cited by 42 publications

(34 citation statements)

References 56 publications

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“…Significant pain responses were also recorded since after 6 months of treatment the mean pain score decreased by 5.8 points (0-10 scale). Similarly, statistically significant improvements were noted for patients' quality of life and performance status mean scores [4].…”

Section: Dear Editormentioning

confidence: 70%

“…These studies unfortunately were not discussed in the manuscript we were commenting on and are summarized below, since they may be of interest for your readers. Kouloulias et al [2][3][4] used radiotherapy in combination with pamidronate to manage bone metastases from several primary tumors. Patients were managed with monthly intravenous infusions of 180 mg pamidronate and external radiotherapy (total dose of 30 Gy).…”

Section: Dear Editormentioning

confidence: 99%

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Clinical and radiologic response in patients with bone metastases managed with combined radiotherapy and bisphosphonates

Vassiliou

Kardamakis

Kalogeropoulou

2008

Journal of Surgical Oncology

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Section: Dear Editormentioning

confidence: 70%

Section: Dear Editormentioning

confidence: 99%

Clinical and radiologic response in patients with bone metastases managed with combined radiotherapy and bisphosphonates

Vassiliou

Kardamakis

Kalogeropoulou

2008

Journal of Surgical Oncology

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“…The concurrent application of RT and Bps has shown to bring about a significant pain response, enhanced reossification and improved quality of life in patients with bone metastases from a variety of solid tumors [70][71][72][73]. This is a result of an additive and synergistic effect of the two treatment modalities on osteoclast function [70,72].…”

Section: Concurrent Application Of Bisphosphonates and Radiotherapymentioning

confidence: 99%

“…This is a result of an additive and synergistic effect of the two treatment modalities on osteoclast function [70,72].…”

Section: Concurrent Application Of Bisphosphonates and Radiotherapymentioning

confidence: 99%

Management of bone metastases: recent advances and current status

Dennis¹,

Vassiliou²,

Balboni³

et al. 2012

J Radiat Oncol

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This narrative review summarizes new and existing local and systemic management strategies for bone metastases from the fields of radiation oncology, medical oncology and orthopaedic surgery. Local management strategies are organized according to different clinical scenarios, with complicated bone metastases defined as those with associated pathological fractures, soft tissue components or those compressing the spinal cord or cauda equina, and uncomplicated lesions defined as those without these adverse features. The distinction applies for both sclerotic and lytic lesions. Systemic strategies are organized according to classes of therapeutic agents.

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“…pamidronate or zoledronic acid may be useful in the treatment of pain caused by bone metastases, when used with concurrent systemic chemotherapy and/or hormonal therapy, there is insufficient evidence to support its role as adjunctive therapy to radiation therapy when no other systemic treatment is being used [46]. However, promising clinical data indicated significant increases in bone mass and bone formation in breast cancer patients with bone metastases, who received long-term pamidronate together with local radiation therapy [47].…”

Section: Bp and Radiotherapy Combination In Breast Cancermentioning

confidence: 99%

Bisphosphonate treatment and radiotherapy in metastatic breast cancer

2008

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Patients with advanced breast cancer frequently develop metastasis to bone. Bone metastasis results in intractable pain and high risk of pathologic fractures due to osteolysis. The treatment of breast cancer patients with bone metastases requires a multidisciplinary approach. Radiotherapy is an established treatment for metastatic bone pain. It may be delivered either as a localized low dose treatment for localized bone pain or systemically for more widespread symptoms. Bisphosphonates have been shown to reduce morbidity and bone pain from bone metastases when given to patients with metastatic bone disease. In vivo studies indicate that early bisphosphonates administration in combination with radiotherapy improves remineralization and restabilization of osteolytic bone metastases in animal tumor models. This review focused on a brief discussion about biology of bone metastases, the effects of radiotherapy and bisphosphonate therapy, and possible mechanisms of combination therapy in metastatic breast cancer patients.

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Cited by 42 publications

References 56 publications

Clinical and radiologic response in patients with bone metastases managed with combined radiotherapy and bisphosphonates

Clinical and radiologic response in patients with bone metastases managed with combined radiotherapy and bisphosphonates

Management of bone metastases: recent advances and current status

Bisphosphonate treatment and radiotherapy in metastatic breast cancer

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