Radiotherapy for unilesional mycosis fungoides

Radiotherapy for Mycosis Fungoides: Review of the Literature

“…In the study by Micaily, et al, a complete response rate of 100% was achieved using a median local electron radiation dose of 30.6 Gy with resolution of all treated lesions within 1 to 2 months after radiotherapy [47]. There were no recurrent disease or systemic progression and no treatment-induced long-term toxicities.…”

“…In early stage disease presenting with solitary lesion limited to a single anatomic site, radiotherapy may be used to achieve the primary goal of disease eradication along with improvement of clinical symptoms and prevention of progressive disease [45][46][47][48][49].…”

“…A wide range of radiotherapy doses from 6 to 40 Gy has been used in the management of unilesional MF with typical treatment margins of ≥ 2 centimeters [6, 47,48]. A dose range of 20 to 30 Gy may be feasible and a recent guideline from the International Lymphoma Radiation Oncology Group recommends a dose range of 20 to 24 Gy for radiotherapy of patients with unilesional MF [5,6].…”

“…There were no recurrent disease or systemic progression and no treatment-induced long-term toxicities. At 10 years, reported rates of overall survival and relapse-free survival were 100% and 86.2%, respectively [47].…”

The dose penumbra of a custom‐made shield used in hemibody skin electron irradiation

“…For patients with early stage disease limited to one location, local treatment with electrons can induce complete response and potentially even cure (4) . For patients with more widespread disease, treatment with total skin electron irradiation (TSEI) has been shown to be effective in inducing complete response for prolonged time intervals.…”