Radiotherapy for sinonasal undifferentiated carcinoma

Christopherson, Kaitlin M.; Werning, John W.; Malyapa, Robert S.; Morris, Christopher G.; Mendenhall, William M.

doi:10.1016/j.amjoto.2013.10.001

Cited by 28 publications

(20 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other published series also reported a median survival time of 9-30 months. [14][15][16][17] The median survival time of 29.3 months and the three-year progressionfree survival rate of 41 per cent in the present cohort are consistent with those of published series. A summary of published data on the characteristics, treatment and outcomes of sinonasal undifferentiated carcinoma patients is given in Table III.…”

Section: Discussionsupporting

confidence: 81%

“…In the present study, the local control rate at two years was 86 per cent, comparable to previous reports. 4,17 Median, 29.3 mon * Overall survival, unless otherwise indicated. y = year(s); Pts = patients; LC = local control; RC = regional control; PFS = progression-free survival; Sx = surgery; PORT = post-operative radiotherapy; CT = chemotherapy; RT = radiotherapy; CRT = chemoradiotherapy; NA = not available; NART = neoadjuvant radiotherapy; NACT = neoadjuvant chemotherapy; DMFS = distant metastasis free survival; N + = node positive; pre-op = pre-operative; 3D = three-dimensional; CSS = cause-specific survival; OS = overall survival; ACT = adjuvant chemotherapy; NACRT = neoadjuvant chemoradiotherapy; mon = months; POCRT = post-operative chemoradiotherapy; LRC = locoregional control; DFS = disease-free survival…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A multimodality approach to sinonasal undifferentiated carcinoma: a single institute experience

et al. 2016

View full text Add to dashboard Cite

Background: Sinonasal undifferentiated carcinoma is a rare aggressive tumour arising from the Schneiderian epithelium lining the sinonasal tract. Although considered the cornerstone of therapy, surgical resection can only be performed in a limited number of patients. This report describes the experience of treating sinonasal undifferentiated carcinoma with a multimodality approach.Method: The treatment charts of sinonasal undifferentiated carcinoma patients treated at a tertiary care centre from 2004 to 2012 were retrospectively reviewed.Results: A total of 16 sinonasal undifferentiated carcinoma patients with a median age at diagnosis of 47.5 years (range 8-65 years) were included: 19 per cent had neck nodal metastasis at presentation. Four patients (25 per cent) underwent surgery: of these, two had post-operative radiotherapy, one had pre-operative radiotherapy and one had adjuvant chemotherapy alone. Six patients (38 per cent) received definitive radiotherapy: five had received neoadjuvant chemotherapy to reduce tumour size and help in radiotherapy planning, while four (25 per cent) received palliative radiotherapy. The median follow up was 10.4 months (range 1-42.5 months). The estimated median progression-free survival time was 29.3 months. One-and three-year progression-free survival rates were 77 per cent and 41 per cent, respectively.Conclusion: Surgery is the best treatment option for sinonasal undifferentiated carcinoma, although most patients require post-operative radiotherapy for advanced disease and close tumour margins. Definitive radiotherapy with or without chemotherapy may be suitable for patients with inoperable locally advanced disease. Elective nodal irradiation to address the high nodal involvement rates should be considered to improve the survival rate.

show abstract

Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

A multimodality approach to sinonasal undifferentiated carcinoma: a single institute experience

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Despite advances in RT, side effects are still present, and can be severe depending on the location of the tumor and dose of radiation . Risk factors include age and concurrent or subsequent chemotherapy, whereas side effects include radiation retinopathy, osteoradionecrosis, radiation necrosis, and pseudoprogression . Though advanced radiotherapy modalities such as IMRT have dramatically reduced the amount of side effects by decreasing the tissue exposed to radiation, the high doses commonly given for sinonasal cancers compared to other head and neck locations can still cause damage to the orbit, craniofacial skeleton, and intracranial structures.…”

Section: Discussionmentioning

confidence: 99%

Incidence of intracranial radiation necrosis following postoperative radiation therapy for sinonasal malignancies

Shah

Chiu

et al. 2016

The Laryngoscope

View full text Add to dashboard Cite

show abstract

“…We know certain histologies, such as adenoid cystic carcinoma, are likely to progress with pulmonary metastases, but other minor salivary gland cancers and neuroendocrine malignancies have less predictable patterns of distant progression. Several case reports and small series have highlighted a unique pattern of recurrence in the leptomeninges . These recurrences are often very difficult to manage due to the lack of effective systemic therapy, limited surgical options, and the challenge in delivering meaningful doses of cranial radiation, especially in patients who have previously undergone radiation to skull base structures during primary or adjuvant therapy.…”

Section: Introductionmentioning

confidence: 99%

Isolated leptomeningeal progression from sinonasal carcinomas: Implications for staging workup and treatment

et al. 2019

Self Cite

View full text Add to dashboard Cite

Purpose: To evaluate the rate and risk factors of isolated leptomeningeal progression in sinonasal carcinomas. Methods: We retrospectively reviewed imaging and clinical records to determine progression patterns, and estimated rates using the Kaplan-Meier method. We evaluated risk factors using proportional hazard regression. Results: We analyzed 120 patients who received adjuvant or primary radiotherapy for sinonasal carcinomas. Most patients had T4 disease (68%) and underwent surgery (84%) and chemotherapy (72%). Twenty-seven (23%) patients developed distant metastases (DM), including 20 (17%) with isolated DMs. Leptomeningeal progression was the most common site of isolated DMs (n = 9; 45%) with an average disease-free interval of 1.2 years (0.1-4.3 years). High-grade histology (P = 0.0003), intracranial invasion (P < 0.0001), and neuroendocrine histology (P = 0.06) were associated with increased risk. Conclusions: Isolated leptomeningeal progression is a common pattern of DM in advanced sinonasal carcinomas. We recommend adding cerebrospinal fluid cytology and contrast-enhanced spine MRI to routine staging evaluations for high-risk patients.

show abstract

Radiotherapy for sinonasal undifferentiated carcinoma

Cited by 28 publications

References 18 publications

A multimodality approach to sinonasal undifferentiated carcinoma: a single institute experience

A multimodality approach to sinonasal undifferentiated carcinoma: a single institute experience

Incidence of intracranial radiation necrosis following postoperative radiation therapy for sinonasal malignancies

Isolated leptomeningeal progression from sinonasal carcinomas: Implications for staging workup and treatment

Contact Info

Product

Resources

About