Radiotherapy for Palliation of Locally Advanced Prostatic Carcinoma

Kynaston, Howard; Keen, C.W.; Matthews, P. N.

doi:10.1111/j.1464-410x.1990.tb15000.x

Cited by 23 publications

(9 citation statements)

References 5 publications

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“…This palliative and hemostatic approach is mainly used due to its antitumoral effects and easy administration. Moreover, its cytotoxic effects allow for limitation or regression of an irradiated tumor, which can provide a decrease in tumor--specific symptoms (14,21).…”

Section: Discussionmentioning

confidence: 99%

The efficacy of hemostatic radiotherapy for bladder cancer-related hematuria in patients unfit for surgery

et al. 2013

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Objective: The aim of our study was to assess short and mid-term clinical efficacy of external beam radiation therapy to achieve hemostasis in patients with bladder-cancer related gross hematuria who were unfit for surgery. We also assessed hypofractionation as a possible alternative option for more severe patients. Patients and Methods: Thirty-two patients were included for hemostatic radiation therapy, with two schedules based on Eastern Cooperative Oncology Group performance status. The standard treatment was 30 Gy in 10 fractions over 2 weeks. More severe patients underwent a hypofractionated regimen, with 20 Gy in 5 fractions over a one week period. Clinical evaluation was performed at 2 weeks and 6 months. Results: At 2 weeks, 69% of patients were hematuria-free. Subgroup analysis showed that 79% of patients undergoing hypofractionated regimen were hematuria-free. A total of 54% were hematuria-free with the standard regimen. Based on tumor stage, hematuria was controlled at 2 weeks for 57% of non-muscle invasive tumors and 72% of muscle--invasive tumors. After 6 months, 69% of patients had relapsed, regardless of tumor stage or therapy schedules. Conclusions: Hemostatic radiotherapy is an effective option for palliative-care hematuria related to bladder cancer in patients unfit for surgery. Although it appears to be rapidly effective, its effect is of limited duration. Hypofractionation also seems to be an effective option; however larger cohorts and prospective trials are needed to evaluate its efficacy compared to standard schedules.

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Section: Discussionmentioning

confidence: 99%

The efficacy of hemostatic radiotherapy for bladder cancer-related hematuria in patients unfit for surgery

et al. 2013

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“…Stoner E, Round E, Ferguson D, Gormley GJ and The Finasteride Study Group: clinical experience of the detection grade and the time to alleviate outlet obstruction, the of prostate cancer in patients with benign prostatic only patients in whom outlet obstruction was not hyperplasia treated with finasteride. Palliative radiation urethral strictures and bladder neck contractures.benefit may be achieved using short palliative regimens Int J Radiat Biol Phys 1986; 12: 1597-1600[16] and this is reflected in the present study where12 Lange PH. Although three patients developed obstruc-5 Devonec M, Fendler JP, Monsaillier M et al The significance tion requiring catheterization during treatment, the cathof the prostatic hypoechoic area: results in 226 ultraeter was removed successfully in each case.…”

mentioning

confidence: 53%

The effect of radiotherapy on urethral obstruction from carcinoma of the prostate

Wells

Hoskin

Towler

et al. 1996

British Journal of Urology

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Objective To assess the impact of radiotherapy on the The grade and stage of tumour did not influence the duration of catheterization. The median time from relief of complete bladder outlet obstruction requiring catheterization secondary to prostatic carcinoma.completion of radiotherapy to catheter removal was 10 weeks (range 0-46). Recatheterization was Patients and methods From a consecutive series of 151 patients treated with radiotherapy for localized carci-required in two patients at 3 and 64 months after radiotherapy and three patients, including these two, noma of the prostate, 19 (12.6%; median age 72 years, range 59-83) who had an indwelling catheter required transurethral prostatectomy (TURP) to relieve outlet obstruction. in situ at the time of irradiation because of urinary retention, were analysed retrospectively and groupedConclusion Prostatic radiotherapy is effective in relieving bladder neck obstruction caused by prostate cancer. according to the stage and grade of tumour and the irradiation dose delivered.Most patients will achieve normal urinary function without requiring TURP after treatment. Results The catheter was removed following radiotherapy in all but two patients, who both had stage 4 Keywords Bladder outlet obstruction, prostate cancer, radiotherapy tumours, and normal urinary function was restored.have profound implications on the selection of treatment,

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“…Radiation therapy is employed to control bleeding in patients with cancer. Multiple tumor sites have been successfully treated (1)(2)(3)10,11) . The treatment regimen required to achieve hemostasis varies according to the specific clinical situation.…”

Section: Discussionmentioning

confidence: 99%

High dose rate (HDR) cervical ring applicator to control bleeding from cervical carcinoma

Grigsby

Portelance

Williamson

2002

Int J Gynecol Cancer

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Grigsby PW, Portelance L, Williamson JF. High dose rate (HDR) cervical ring applicator to control bleeding from cervical carcinoma. Int J Gynecol Cancer 2002;12:18-21. The objective of this study was to evaluate the use of the high dose rate (HDR) cervical ring applicator to control acute cervical bleeding from carcinoma of the uterine cervix. This study consists of 15 patients presenting with invasive carcinoma of the uterine cervix with acute vaginal bleeding requiring transfusion. Initial irradiation, delivered emergently because of vaginal bleeding, consisted of two fractions (5 Gy each fraction to the surface of the cervix) utilizing the HDR intracavitary vaginal ring applicator. Two fractions were administered at one week intervals for a total of 10 Gy to the surface of the cervix. Irradiation doses from the HDR ring applications were not considered into the composite total dose to point A. Diagnostic imaging evaluation and initiation of external irradiation were commenced during this initial weekly interval between fractions. Vaginal bleeding requiring no additional transfusions was achieved in 93% (14/15) of patients. No acute or long-term Grades 3, 4, or 5 bowel or bladder sequelae were noted. In conclusion, HDR cervical ring brachytherapy is effective in controlling acute vaginal bleeding and can be delivered without undue acute or long-term toxicity.

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Radiotherapy for Palliation of Locally Advanced Prostatic Carcinoma

Cited by 23 publications

References 5 publications

The efficacy of hemostatic radiotherapy for bladder cancer-related hematuria in patients unfit for surgery

The efficacy of hemostatic radiotherapy for bladder cancer-related hematuria in patients unfit for surgery

The effect of radiotherapy on urethral obstruction from carcinoma of the prostate

High dose rate (HDR) cervical ring applicator to control bleeding from cervical carcinoma

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