Radiotherapy for newly diagnosed malignant glioma in adults: a systematic review

Laperrière, Normand; Zuraw, Lisa; Cairncross, Gregory

doi:10.1016/s0167-8140(02)00078-6

Cited by 361 publications

(179 citation statements)

References 70 publications

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“…Nevertheless, the incidences of recurrence, regrowth, and dissemination of the tumor are very high due to the well-known infiltrative extension far beyond the boundaries of the localized lesion identifiable with neuroimaging. 4,20,33,37,48) The progression of glioblastoma after treatment in up to 97% of cases occurs either from the bulk of the mass or within 20 mm from the border of its enhanced part identifiable on T 1 -weighted magnetic resonance (MR) imaging, and the presence of such local recurrence may be associated with impaired prognosis. 2,3,12,13,23,25,32,34,35,43,44,54) Therefore, various methods for improvement of tumor control at the time of both initial and salvage treatment have been proposed, such as inclusion of the marginal brain tissue in the high dose area during FRT, 4,17,20,26,31-33, 35,49,50) additional dose boost with stereotactic radiosurgery, 14,18,41) brachytherapy, 10,36,43) implantation of Gliadel wafers (Guilford Pharmaceuticals Inc., Baltimore, Maryland, USA), 53) or various types of intralesional immunotherapy.…”

Section: Introductionmentioning

confidence: 99%

Patterns of Intracranial Glioblastoma Recurrence After Aggressive Surgical Resection and Adjuvant Management: Retrospective Analysis of 43 Cases

Konishi

Muragakı

Iseki

et al. 2012

Neurol. Med. Chir.(Tokyo)

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The present retrospective study evaluated the recurrence patterns after aggressive surgical removal of intracranial glioblastomas in 43 consecutive adult patients. The resection rate of the enhanced lesion on magnetic resonance imaging was 100% and 95-99% in 22 and 21 cases, respectively. All patients received postoperative fractionated radiotherapy (60 Gy in 30 fractions) with additional chemotherapy (25 cases) or vaccine therapy (18 cases). During follow-up (median 17 months), tumor recurrence was identified in 33 patients, most frequently regional within the wall of the resection cavity (20 cases). No clinical factor differed significantly between the groups of patients with regional or marginal tumor progression (N ＝ 22) and patients with distant or multiple recurrences (N ＝ 8). Progression-free survival did not differ significantly between these two groups (p ＝ 0.27). However, overall survival was significantly longer (p ＝ 0.04) in patients with regional or marginal tumor progression, and constituted 90% and 54% at 1 and 2 years after surgery, respectively, compared to 75% and 0% in patients with distant or multiple recurrences. Aggressive surgical resection and adjuvant management of intracranial glioblastoma may change its recurrence pattern. Tumor progression appears in the wall of the resection cavity or within 2 cm from its margin in approximately half of patients.

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Section: Introductionmentioning

confidence: 99%

Patterns of Intracranial Glioblastoma Recurrence After Aggressive Surgical Resection and Adjuvant Management: Retrospective Analysis of 43 Cases

Konishi

Muragakı

Iseki

et al. 2012

Neurol. Med. Chir.(Tokyo)

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“…To evaluate the clinical and therapeutic management of malignant astrocytoma patients in Italy, 12 Italian radiation oncology centers decided to collaborate in the analysis of their patterns of practice during the last 2 decades, to create a background for future studies. This report is related to the decision to create a group for the study of central nervous system tumors, which was approved by the Steering Committee of the Italian Society for Radiation Oncology in June 2005.…”

Section: Introductionmentioning

confidence: 99%

Patterns of practice and survival in a retrospective analysis of 1722 adult astrocytoma patients treated between 1985 and 2001 in 12 Italian radiation oncology centers

Magrini

Ricardi

Santoni

et al. 2006

International Journal of Radiation Oncology*Biology*Physics

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“…For patients with high-grade gliomas, it is recommended that a total dose of 50-60 Gy external radiation be delivered postoperatively. 26 For patients with metastatic thyroid cancer, 131 I therapy is believed to be effective when tumor absorbed dose is greater than 80 Gy. 27 Assuming a uniform distribution of radioactivity in a 1 mm diameter spherical F98/hNIS glioma in a rat treated with 16 mCi of 131 I 14 DPI, we estimated the absorbed dose to be 26 Gy (1.6 Gy/mCi), using the MIRD method.…”

Section: Discussionmentioning

confidence: 99%

Effects of dose, intervention time, and radionuclide on sodium iodide symporter (NIS)-targeted radionuclide therapy

et al. 2004

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The sodium iodide symporter (NIS) mediates iodide uptake into thyrocytes and is the molecular basis of thyroid radioiodine therapy. We previously have shown that NIS gene transfer into the F98 rat gliomas facilitated tumor imaging and increased survival by radioiodine. In this study, we show that: (1) the therapeutic effectiveness of 131 I in prolonging the survival time of rats bearing F98/hNIS gliomas is dose-and treatment-time-dependent; (2) the number of remaining NISexpressing tumor cells decreased greatly in RG2/hNIS gliomas post 131 I treatment and was inversely related to survival time; (3) 8 mCi each of 125 I/ 131 I is as effective as 16 mCi 131 I alone, despite a smaller tumor absorbed dose; (4) 188 ReO 4 , a potent b À emitter, is more efficient than 131 I to enhance the survival of rats bearing F98/hNIS gliomas. These studies demonstrate the importance of radiopharmaceutical selection, dose, and timing of treatment to optimize the therapeutic effectiveness of NIS-targeted radionuclide therapy following gene transfer into gliomas.

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Radiotherapy for newly diagnosed malignant glioma in adults: a systematic review

Cited by 361 publications

References 70 publications

Patterns of Intracranial Glioblastoma Recurrence After Aggressive Surgical Resection and Adjuvant Management: Retrospective Analysis of 43 Cases

Patterns of Intracranial Glioblastoma Recurrence After Aggressive Surgical Resection and Adjuvant Management: Retrospective Analysis of 43 Cases

Patterns of practice and survival in a retrospective analysis of 1722 adult astrocytoma patients treated between 1985 and 2001 in 12 Italian radiation oncology centers

Effects of dose, intervention time, and radionuclide on sodium iodide symporter (NIS)-targeted radionuclide therapy

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