Radiotherapy for nasolacrimal tract epithelial cancer

Sagerman, Robert H.; Fariss, Anna K.; Chung, Chung T.; King, Gerald A.; Yuo, Hae Sook; Fries, Peter D.

doi:10.1016/0360-3016(94)90241-0

Cited by 19 publications

(7 citation statements)

References 17 publications

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“…Acute toxicity of radiotherapy is low and is limited to conjunctival or cutaneous hyperemia, and delayed toxicity leads to xerophthalmia, radiation retinopathy, glaucoma, cataract, or keratitis with corneal ulcerations. 5 Weekly physical examination during radiation therapy can diagnose acute toxicities and handle them promptly. No patients in this study ceased or delayed radiation therapy because of severe acute toxicity.…”

Section: Discussionmentioning

confidence: 99%

“…2 Previous results demonstrated the treatment efficacy of irradiation being used as adjuvant therapy in postoperative patients with lacrimal sac tumors. 5 Especially for the patients with LSSCC who are unfit for multidisciplinary therapy, or refuse such therapy, definitive Objectives: Tumors of the lacrimal sac are rare and life-threatening. Because of their rarity, no extensive clinical data on their management and prognosis exist.…”

Section: Introductionmentioning

confidence: 99%

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Treatment outcomes after definitive radio(chemo)therapy for 17 lacrimal sac squamous cell carcinoma

Song

He²,

Zhu

et al. 2020

BJR

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Objectives: Tumors of the lacrimal sac are rare and life-threatening. Because of their rarity, no extensiveclinical data on their management and prognosis exist. We investigated the application of definitive radiation therapy and its outcome in patients with lacrimal sac squamous cell carcinoma (LSSCC). Methods: We retrospectively studied 17 patients with LSSCC at a single institution between 2003 and 2017. All the patients were treated with treated with definitive radiotherapy, and 11 patients were delivered with cisplatin-based chemotherapy. The patients’ clinical records were reviewed for symptoms, pathological types, the volume and dosimetry of the tumors and their adjacent structures, radiation coverage of lymph node drainage areas, treatment outcomes, and complications from definitive radiotherapy. Results: Medianfollow-up was 38.9 months, and age at diagnosis was 48 years.The2-year and 5 year overall survival, progression-free survival, locoregional control, and disease metastasis-free survival rates were 94.1 and 84.7%, 88.2 and 73.5%, 93.8%, 94.1 and 78.4%, respectively. A total dose of 6600–7000 cGy was prescribed to the tumor. Levels Ⅰb, Ⅶa, Ⅷ, and Ⅸ were covered with the clinical target volume regardless of lymph involvement. Acute Grade three radiation dermatitis occurred in seven patients (17.6%), but no acute Grade 4 or Grade 5 toxicity of any type occurred. Seven (41.2%, 7/17) of the treated eyes had moderated vision impairments; 17.6% (3/17) of patients developed cataracts, and glaucoma and radiation retinopathy were found in 5.9% (1/17) of patients. Conclusions: Definitive radiotherapy could be a treatment option for those who refuse surgery or have unresectable LSSCC. Advances in knowledge: Radiation alone is a treatment option for LSSCC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Treatment outcomes after definitive radio(chemo)therapy for 17 lacrimal sac squamous cell carcinoma

Song

He²,

Zhu

et al. 2020

BJR

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“…11 Eight patients received postoperative radiation therapy, of which 2 patients (patient 1 and 6) were known to have positive tissue margins. 11 Eight patients received postoperative radiation therapy, of which 2 patients (patient 1 and 6) were known to have positive tissue margins.…”

Section: Discussionmentioning

confidence: 99%

En Bloc Resection of Lacrimal Sac Tumors and Simultaneous Orbital Reconstruction

Alabiad¹,

Weed²,

Walker³

et al. 2014

Ophthalmic Plastic &Amp; Reconstructive Surgery

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The combined sinus-orbit approach is an effective method of managing lacrimal sac tumors to achieve optimal tumor clearance from the orbit and nasal cavity. Simultaneous reconstruction of the bony defect with a contoured titanium mesh provides a fixation anchor for the medial canthal tendon and globe support and serves as a supporting platform for the lower eyelid and cheek to minimize midface collapse. Postoperative radiation is associated with skin flap breakdown and nasocutaneous fistula formation.

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“…Von der Mehrzahl der Autoren wird eine Nachbestrahlung empfohlen [9,10]. Alternativ zum chirurgischen Vorgehen wurde eine alleinige Strahlentherapie bei epithelialen Karzinomen vorgeschlagen, wobei hier lediglich über 3 Fälle berichtet wird [19].…”

Section: Diagnostikunclassified