Radiotherapy for local control of osteosarcoma

DeLaney, Thomas F.; Park, Lily; Goldberg, Saveli; Hug, Eugen B.; Liebsch, Norbert J.; Munzenrider, John E.; Suit, Herman D.

doi:10.1016/j.ijrobp.2004.05.051

Cited by 254 publications

(171 citation statements)

References 19 publications

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“…This has resulted in improved survival, but these studies have been primarily limited to patients with limb and not spine involvement. Delaney et al [10] found a significant 5-year survival advantage between patients who underwent surgical resection (75 %) relative to those who underwent biopsy (25 %) for patients with osteosarcoma. Of the 41 patients in this series, patients with metastatic disease were included and only eight patients had spine involvement [10].…”

Section: Discussionmentioning

confidence: 99%

Association of surgical resection and survival in patients with malignant primary osseous spinal neoplasms from the Surveillance, Epidemiology, and End Results (SEER) database

et al. 2012

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Objective Malignant osseous spinal neoplasms are aggressive tumors associated with poor outcomes despite aggressive multidisciplinary measures. While surgical resection has been shown to improve short-term local disease control, it remains debated whether surgical resection is associated with improved overall survival in patients with malignant primary osseous spinal neoplasms. The aim of this manuscript is to review survival data from a US cancer registry spanning 30 years to determine if surgical resection was independently associated with overall survival. Methods The SEER registry was queried to identify cases of histologically confirmed primary spinal chordoma, chondrosarcoma, osteosarcoma, or Ewing's sarcoma of the mobile spine and pelvis. Patients with systemic metastasis were excluded. Age, gender, race, tumor location, and primary treatments were identified. Extent of local tumor invasion was classified as confined within periosteum versus extension beyond periosteum to surrounding tissues. The association of surgical resection with overall survival was assessed via Cox analysis adjusting for age, radiotherapy, and tumor invasiveness.Results 827 patients were identified with non-metastatic primary osseous spinal neoplasms (215 chordoma, 282 chondrosarcoma, 158 osteosarcoma, 172 Ewing's sarcoma). Overall, median survival was histology specific (chordoma, 96 months; Ewing's sarcoma, 90 months; chondrosarcoma, 88 months; osteosarcoma, 18 months). Adjusting for age, radiation therapy, and extent of local tumor invasion in patients with isolated (non-metastatic) spine tumors, surgical resection was independently asso- Conclusion In our analysis of a 30-year US populationbased cancer registry (SEER), patients undergoing surgical resection of primary spinal chordoma, chondrosarcoma, Ewing's sarcoma, or osteosarcoma demonstrated prolonged overall survival independent of patient age, extent of local invasion, or location. Surgical resection may play a role in prolonging survival in the multi-modality treatment of patients with these malignant primary osseous spinal neoplasms.

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Section: Discussionmentioning

confidence: 99%

Association of surgical resection and survival in patients with malignant primary osseous spinal neoplasms from the Surveillance, Epidemiology, and End Results (SEER) database

et al. 2012

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“…Our method differs from those described by others [7,9,10,14]. In some regards DCs are believed to be the principal APCs for initiating immune responses in vivo [32].…”

Section: Discussionmentioning

confidence: 99%

“…Many groups have reported successful immunotherapy for osteosarcoma [5,15,18,20,22,24,25,33,34,36,42,51,52]. However, the ability to control metastatic lesions and local recurrence does not appear to be superior to other adjuvant treatments [2,7,13,23,29].…”

Section: Introductionmentioning

confidence: 99%

Cryoimmunologic Antitumor Effects Enhanced by Dendritic Cells in Osteosarcoma

Kawano

Nishida

Nakamoto

et al. 2010

Clinical Orthopaedics &Amp; Related Research

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Background We previously reported a limb-salvage technique by treating tumor-bearing bone with liquid nitrogen. We also reported systemic antitumor immunity was enhanced by cryotreatment in a murine osteosarcoma (LM8) model. We therefore combined the cryotreatment of tumor with dendritic cells to promote tumor-specific immune responses. Questions/purposes We determined whether our technique could enhance systemic immune response and inhibit metastatic tumor growth in a murine osteosarcoma model. Materials and Methods To evaluate activation of the immune response, we prepared six groups of C3H mice (80 mice total): (1) excision only, (2) dendritic cells without reimplantation of the cryotreated primary tumor, (3) reimplantation of the cryotreated primary tumor alone, (4) dendritic cells combined with reimplantation of the cryotreated primary tumor, (5) dendritic cells exposed to cryotreated tumor lysates without reimplantation of the cryotreated primary tumor, and (6) dendritic cells exposed to cryotreated tumor lysates with reimplantation of the cryotreated primary tumor. We then compared and verified the activation state of each group's antitumor immunity. Results Mice that received dendritic cells exposed to cryotreated tumor lysates with reimplantation of the cryotreated primary tumor group had high serum interferon c, reduced pulmonary metastases, and increased numbers of CD8(+) T lymphocytes in the metastatic areas. Conclusions Combining tumor cryotreatment with dendritic cells enhanced systemic immune responses and inhibited metastatic tumor growth. Clinical Relevance We suggest immunotherapy could be developed further to improve the treatment of osteosarcoma.

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“…13,14 For osteosarcoma, adjuvant radiation has not been shown to improve overall survival after surgery and chemotherapy and therefore is not routinely offered to patients. 28 In addition, prophylactic radiation of the lung fields to prevent pulmonary metastases has been studied in the past, but results from randomized studies have been too inconsistent to support its widespread practice. 29 Future studies of LB100 in osteosarcoma and other tumors with propensity to spread to the lungs may investigate whether LB100 exposure prior to prophylactic lung field radiation may reduce the incidence of pulmonary metastases in tumor models, in vivo.…”

Section: Discussionmentioning

confidence: 99%