Radiotherapy for human papillomavirus‐positive oropharyngeal cancers in the National Cancer Data Base

HPV status in unknown primary head and neck cancer: Prognosis and treatment outcomes

“…Human papillomavirus (HPV)‐associated head and neck squamous cell carcinomas (HNSCC) are molecularly distinct compared to tobacco‐associated HNSCC, with different protein and gene expression patterns . As with other malignancies of the head and neck, HPV status may also be an important contributor to treatment‐associated outcomes for HNCUP . The incidence of HPV‐associated head and neck cancer has been rising, with recent studies suggesting that 60% to 70% of new oropharyngeal squamous cell carcinoma (OPSCC) cases in the United States are HPV‐related .…”

“…[18][19][20] As with other malignancies of the head and neck, HPV status may also be an important contributor to treatmentassociated outcomes for HNCUP. 21,22 The incidence of HPV-associated head and neck cancer has been rising, 23,24 with recent studies suggesting that 60% to 70% of new oropharyngeal squamous cell carcinoma (OPSCC) cases in the United States are HPV-related. [23][24][25] Given the improved prognosis for HPV-associated OPSCC, [26][27][28][29][30][31] some have proposed deintensification of treatment for these cases, although some recent work suggests possible risk associated with this approach.…”

Changing prognosis of oral cancer: An analysis of survival and treatment between 1973 and 2014

“…Patients were diagnosed between January 1, 2004 and December 31, 2012 in the NCDB and between January 1, 1973 and December 31, 2014 in SEER. These registries have been used in a number of studies of outcomes in head and neck malignancies . This study was determined to be exempt from institutional review by the Yale Human Investigation Committee.…”

“…These registries have been used in a number of studies of outcomes in head and neck malignancies. 7,[15][16][17][18][19] This study was determined to be exempt from institutional review by the Yale Human Investigation Committee.…”

Adjuvant Chemotherapy Is Associated With Improved Survival for Late‐Stage Salivary Squamous Cell Carcinoma

“…The NCDB is a nationwide clinical surveillance resource data set that includes approximately 70% of all newly diagnosed malignancies in the United States from over 1,500 cancer programs, as previously described . The NCDB has been used in a number of studies to study treatment‐related outcomes in head and neck malignancies . This study was determined to be exempt from institutional review by the Yale Human Investigation Committee.…”