Radiotherapy for cutaneous squamous and basal cell carcinomas of the head and neck

Mendenhall, William M.; Amdur, Robert J.; Hinerman, Russell W.; Cognetta, Armand B.; Mendenhall, Nancy P.

doi:10.1002/lary.20608

Cited by 145 publications

(99 citation statements)

References 24 publications

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“…Radiation therapy is also an option for patients reluctant or unable to undergo surgery or in the case of positive margins or extensive peri-neural invasion [31] [32] [33]. In very rare cases, usually after repeated local recurrences, large and deeply infiltrative BCCs may metastasize to lymph nodes or distant sites, such as the lung, and become lethal [34] [35] [36].…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Pattern of Basal Cell Carcinoma among Sudanese Patients

Sulieman¹,

Husain²

2017

OJPathology

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Background: Basal cell carcinoma (BCC) is a frequently diagnosed skin cancer with variable histopathological types. BCC was not widely studied in Sudan as it is in the Caucasian population. Objectives: To appraise the clinical and histopathological aspects of BCC of the skin in Sudan. Materials and methods: A retrospective descriptive analysis of 84 histologically diagnosed BCC specimens seen at three hospitals in four-year duration were reviewed and classified into histological variants according to the WHO classification 2006. Data were analyzed using Statistical Package for the Social Sciences, version 23.0. Results: The mean age (±SD) of the study participants was 56 (±1.75) years, ranging from 20 to 92 years and 63.1% were females (Female to male ratio 1.7:1). The most common incidence was among the age group 51 -60 years. The face was the primary tumor site in 89.3% with a predilection for the nasal area (31% of those in the face), followed by the trunk (6%). Out of the total, 54.8% were histologically categorized as nodular/solid, while infiltrative accounts for 11.9% followed by the superficial type (8.3%). Surgical margins were involved in 34.5% of cases and peri-neural invasion was seen in 3.6% of cases, mostly were of the infiltrative variant. Conclusion: BCC in Sudan is commonly present in the head as solid nodular histopathological variant which is correlated with worldwide distribution but has slightly younger age and female predominance; thus further studies are needed to assess risk factors in Sudanese patients and improve approaches for earlier diagnosis and better management.

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Section: Discussionmentioning

confidence: 99%

Clinicopathological Pattern of Basal Cell Carcinoma among Sudanese Patients

Sulieman¹,

Husain²

2017

OJPathology

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“…There are many standard therapeutic modalities used in treatment of BCC including surgical excision [9], curettage with electrodessica-tion [10], cryotherapy [11], and radiotherapy [12]. Moh's micrographic surgery [13], photodynamic therapy (PDT) [14], laser therapy [15], intralesional interferon [16], and intralesional zinc sulphate 2% [17].…”

Section: Discussionmentioning

confidence: 99%

Treatment of Basal Cell Carcinoma by Topical 25% Podophyllin Solution

Sharquie¹,

Noaimi²,

Al-Zoubaidi³

2015

JCDSA

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K. E. Sharquie et al. 190 dophyllin applications. After 3 -5 days, the reaction became more exaggerated and ulceration developed, ended with crust formation. No evidence of systemic side effects was seen and this had been confirmed clinically and by laboratory during the sessions and one month later. Minimal or no scarring was noticed. Conclusions: Topical 25% podophyllin solution is a new, effective therapeutic modality in treatment of basal cell carcinoma which gives 96% cure, and it is highly recommended as alternative therapy in all type of basal cell carcinoma, single and multiple and for all ages especially for elderly patients and those who have surgeries phobia.

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“…Adjuvant radiation therapy is widely recommended to reduce the local recurrence rate in high-risk patients [4][5]. High-risk factors include a lesion larger than 2 cm, location in the mid face or ear, duration without treatment, a history of previous irradiation [6], as well as irregular borders [7].…”

Section: Discussionmentioning

confidence: 99%