Radiotherapy for age-related macular degeneration

Gibbs, Suzanne; Bird, Alan C.; Owens, Sarah L.; Plowman, P N

doi:10.1016/s0936-6555(98)80029-0

Cited by 6 publications

(1 citation statement)

References 30 publications

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“…One week after completion of the behavioral tests mice (5 Nenf +/+ and 5 Nenf −/− ) were transcardialy perfused with 0.9% saline under deep anesthesia and brains were removed for Golgi-Cox staining (Gibbs et al, 1998). Briefly, brains were immersed in Golgi-Cox solution (a 1:1 solution of 5% potassium dichromate (Merck, Darmstadt, Germany) and 5% mercuric chloride (Merck) diluted 4:10 with 5% potassium chromate (Merck) for 14 d; then transferred to 30% sucrose isolution in 0.5% sodium azide where they were kept until processing.…”

Section: Methodsmentioning

confidence: 99%

Neudesin is involved in anxiety behavior: structural and neurochemical correlates

Novais

Ferreira

Marques

et al. 2013

Front. Behav. Neurosci.

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Neudesin (also known as neuron derived neurotrophic factor, Nenf) is a scarcely studied putative non-canonical neurotrophic factor. In order to understand its function in the brain, we performed an extensive behavioral characterization (motor, emotional, and cognitive dimensions) of neudesin-null mice. The absence of neudesin leads to an anxious-like behavior as assessed in the elevated plus maze (EPM), light/dark box (LDB) and novelty suppressed feeding (NSF) tests, but not in the acoustic startle (AS) test. This anxious phenotype is associated with reduced dopaminergic input and impoverished dendritic arborizations in the dentate gyrus granule neurons of the ventral hippocampus. Interestingly, shorter dendrites are also observed in the bed nucleus of the stria terminalis (BNST) of neudesin-null mice. These findings lead us to suggest that neudesin is a novel relevant player in the maintenance of the anxiety circuitry.

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Section: Methodsmentioning

confidence: 99%