Radiotherapy and Verrucous Carcinoma of the Oral Cavity: A study of 107 cases

Vidyasagar, M S; Fernandes, Daniel; Kasturi, Dinesh Pai; Akhileshwaran, R.; Rao, Kotnur Narayana Mohan; Rao, Samir S.; Rs, Rao; Solomon, J. G. R.

doi:10.3109/02841869209088264

Cited by 40 publications

(35 citation statements)

References 21 publications

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“…Although the older literature raised the issue of radiotherapy-related anaplastic or malignant transformation in VC [3,9,[21][22][23][24][25], this has clearly been refuted. Radiotherapy is now an accepted treatment modality for inoperable VC or for patients who are poor surgical candidates [26,27]. VCs in locations other than the head and neck are treated similarly, with surgery being the first choice for resectable tumors and other modalities being used only for those not amenable to surgery [28,29].…”

Section: Discussionmentioning

confidence: 99%

Verrucous Carcinoma with Dysplasia or Minimal Invasion: A Variant of Verrucous Carcinoma with Extremely Favorable Prognosis

Patel

Chernock

Sinha

et al. 2014

Head and Neck Pathol

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Verrucous carcinomas (VC) recur locally but do not metastasize in the absence of an invasive squamous cell carcinoma (SCC) component. Although excluded from the definition of pure VC, some tumors harbor only dysplasia or minimal invasion, findings of unknown clinical significance. Surgically resected VC cases from two institutions were collected and categorized into three types: VC, VC with dysplasia or minimal invasion (VCDMI), defined as SCC less than or equal to 2 mm in depth, and SCC arising in VC (SCC-VC) where the SCC was greater than 2 mm in depth. Cases were also matched with conventional SCC based on location and T and N-stages, and clinical follow up was obtained. Of the 58 total cases, 18 were VC, 26 VCDMI, and 14 SCC-VC. Only 1 of 18 (5.6 %) VC and 5 of 26 (19.2 %) VCDMI cases recurred locally (p = 0.37) versus 7 of 14 (50 %) SCC-VC (p = 0.01). All VC and VCDMI cases were node negative at presentation whereas SCC-VC had nodal metastases in 2 of 14 (14.3 %) cases. No patients with VC or VCDMI died from disease, whereas 5 of 14 (35.7 %) patients with SCC-VC died from disease. T-stage matched conventional SCC cases from institutional databases had worse outcomes than VC and VCDMI, but not after they were matched for both T and N-stages. Our findings suggest that dysplasia and/or minimal invasive SCC do not adversely affect outcomes in tumors otherwise showing diagnostic features of VC.

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Section: Discussionmentioning

confidence: 99%

Verrucous Carcinoma with Dysplasia or Minimal Invasion: A Variant of Verrucous Carcinoma with Extremely Favorable Prognosis

Patel

Chernock

Sinha

et al. 2014

Head and Neck Pathol

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“…In fact, the treatment policy mainly depends on the extension of the primary tumor and on the regional nodal involvement. The patients who undergo surgery are usually in Stage I or II, whereas radiotherapy (or combined with surgery) appears more suit- (97). It was shown that the 5-year actuarial survival of patients with OVC treated by primary radiotherapy did not show any significant difference when compared to that of patients treated by surgery (98).…”

Section: Treatmentmentioning

confidence: 91%

“…In this regard, the role of radiation in promoting anaplastic transformation, a risk which is certainly over-emphasized, seems questionable and warrants further verification. Table II shows representative satisfactory results obtained by using radiotherapy for OVC treatment (97)(98)(99). Overall, radiotherapy was deemed less effective but an acceptable alternative treatment regimen for OVC.…”

Section: Treatmentmentioning

confidence: 99%

Oral verrucous carcinoma: From multifactorial etiology to diverse treatment regimens (Review)

Peng

Wang

Quan

et al. 2016

International Journal of Oncology

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Abstract. Oral verrucous carcinoma (OVC) is a verrucous variant of oral squamous cell carcinoma (OSCC), which accounts for 2-12% of all oral carcinomas with a 5-year survival rate of only approximately 50%. Enormous effort has been dedicated to this cancer, and the past decades have witnessed significant advances in relevant diagnostic and therapeutic approaches. Currently, there exist three challenges from primary sub-fields of research and clinical practice of the cancer, namely multifactorial etiology, complex molecular mechanism, and deficient treatment. This study reviews the existing literature on the cancer, encompassing its etiology, clinical manifestations and pathology, molecular mechanism, diagnosis and differential diagnosis, and treatment. For improved treatment of OVC, multifactorial etiology analysis, incorporation of effective biomarkers for mechanism illustration, and integration of multidisciplinary modalities are expounded, in an attempt to resolve the challenges and to provide a useful guide for future research in the field.

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“…In the United States, Ackerman's verrucous carcinoma accounts for 2-12% of all oral carcinomas (6)(7)(8)(9). In men over the age of 64, the incidence is 3.2 cases per 100,000 people/year (10).…”

Section: Epidemiologymentioning

confidence: 99%

“…In case of oral verrucous carcinomas, it has been reported that irradiation may lead to metastasis; however, there are specialists who are confidently using this treatment (33)(34)(35). In one study, none of the 16 patients with verrucous carcinoma Virgil Pătraşcu, Alexandra Georgiana Bocîrnea, Raluca Niculina Ciurea had anaplastic transformation characteristics after radiotherapy (36).…”

Section: Treatmentmentioning

confidence: 99%

Verrucous Carcinoma Ackerman — Oral Florid Papillomatosis. Case Presentation

2018

RoJCED

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Radiotherapy and Verrucous Carcinoma of the Oral Cavity: A study of 107 cases

Cited by 40 publications

References 21 publications

Verrucous Carcinoma with Dysplasia or Minimal Invasion: A Variant of Verrucous Carcinoma with Extremely Favorable Prognosis

Verrucous Carcinoma with Dysplasia or Minimal Invasion: A Variant of Verrucous Carcinoma with Extremely Favorable Prognosis

Oral verrucous carcinoma: From multifactorial etiology to diverse treatment regimens (Review)

Verrucous Carcinoma Ackerman — Oral Florid Papillomatosis. Case Presentation

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