Radiotherapy and Radiosurgery for Craniopharyngiomas

Lee, Cheng‐Chia; Ding, Dale; Sheehan, Jason P.

doi:10.1016/b978-0-12-416706-3.00019-2

Cited by 2 publications

(1 citation statement)

References 83 publications

(162 reference statements)

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“…dose needed in hypoxic cells divided by the dose needed in normoxic cells to obtain the same biological effect. The OER decreases with increasing LET, for example, the OER for low-LET radiation such as photons and protons is around 2.5-3.0, whereas the OER for carbon ions is around 1.6-2.0 (42,45). Since the OER of protons is similar to photons, the advantage of proton therapy to overcome hypoxia-induced radioresistance is less obvious than for carbon ions.…”

Section: Photonsmentioning

confidence: 99%

Combination Therapy With Charged Particles and Molecular Targeting: A Promising Avenue to Overcome Radioresistance

et al. 2020

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Radiotherapy plays a central role in the treatment of cancer patients. Over the past decades, remarkable technological progress has been made in the field of conventional radiotherapy. In addition, the use of charged particles (e.g., protons and carbon ions) makes it possible to further improve dose deposition to the tumor, while sparing the surrounding healthy tissues. Despite these improvements, radioresistance and tumor recurrence are still observed. Although the mechanisms underlying resistance to conventional radiotherapy are well-studied, scientific evidence on the impact of charged particle therapy on cancer cell radioresistance is restricted. The purpose of this review is to discuss the potential role that charged particles could play to overcome radioresistance. This review will focus on hypoxia, cancer stem cells, and specific signaling pathways of EGFR, NFκB, and Hedgehog as well as DNA damage signaling involving PARP, as mechanisms of radioresistance for which pharmacological targets have been identified. Finally, new lines of future research will be proposed, with a focus on novel molecular inhibitors that could be used in combination with charged particle therapy as a novel treatment option for radioresistant tumors.

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Section: Photonsmentioning

confidence: 99%

Combination Therapy With Charged Particles and Molecular Targeting: A Promising Avenue to Overcome Radioresistance

et al. 2020

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Radiotherapy and Its Impact on the Nervous System of Cancer Survivors

Kumar

Dutta

Parihar

et al. 2020

CNSNDDT

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Background: Radiotherapy, used routinely for the treatment of nearly all brain tumors, but may lead to progressive and debilitating impairments of cognitive function. The growing evidence support radiation exposure to CNS disrupts diverse cognitive functions including learning, memory, processing speed, attention and executive functions. Objective: The present review highlights the types of radiotherapy and the possible mechanisms of cognitive deficits and neurotoxicity following radiotherapy. Method: The review summarizes the articles from Scopus, PubMed, and Web of science search engines. Description: Radiation therapy uses high-powered x-rays, particles, or radioactive seeds to kill cancer cells, with minimal damage to healthy cells. While radiotherapy has yielded relative success in the treatment of cancer, patients are often plagued with unwanted and even debilitating side effects from the treatment, which can lead to dose reduction or even cessation of treatment. Little is known about the underlying mechanisms responsible for the development of these behavioral toxicities; however, neuroinflammation is widely considered as one of the major mechanisms responsible for radiotherapyinduced toxicities. Conclusion: The present study reviews the different types of radiotherapy available for the treatment of various types of cancers and their associated neurological complications. It also summarizes the doses of radiations used in the variety of radiotherapy, and their early and delayed side effects. Special emphasis is given on the effects of various types of radiation on late side effects on cognitive impairments.

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Radiotherapy and Radiosurgery for Craniopharyngiomas

Cited by 2 publications

References 83 publications

Combination Therapy With Charged Particles and Molecular Targeting: A Promising Avenue to Overcome Radioresistance

Combination Therapy With Charged Particles and Molecular Targeting: A Promising Avenue to Overcome Radioresistance

Radiotherapy and Its Impact on the Nervous System of Cancer Survivors

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