Radiotherapie in den Frühstadien des Morbus Dupuytren. Langzeitergebnisse nach 13 Jahren

Abstract

After a mean follow-up of 13 years radiotherapy is effective in prevention of disease progression and improves patients' symptoms in early-stage Dupuytren's contracture (stage N, N/I). In case of disease progression after radiotherapy, a "salvage" operation is still feasible.

Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target

“…Lack of understanding of the signaling pathways driving disease pathogenesis has meant that there is no specific therapeutic for treating early disease or for preventing recurrence following excision or division of the cord. The absence of valid targets has led to empirical treatment with modalities such as local steroid injection (16,17) or radiotherapy (26,27).…”

Evidence-Based Medicine

“…A study of radiotherapy for early-stage Dupuytren disease showed no progression in 69 percent of treated hands and no treatment-related complications in treated hands that later had surgery for progression. 47 Although this compares favorably with the report of 49 percent of patients with nodules followed an average of 8.7 years without treatment who did not progress to cords or contractures, 48 it is not superior to the report of 65 percent of patients with nodules followed for 18 years with no intervention who did not progress to contractures. 49 In contrast, Seegenschmiedt et al reported greater patient satisfaction and a lower incidence of contracture progression over 5 years in patients with early-stage Dupuytren disease treated with local radiotherapy versus no treatment.…”

Gorham–Stout Syndrome of the Pelvic Girdle Treated by Radiation Therapy

“…RT is known to be effective in a large variety of degenerative and hyperproliferative benign conditions affecting the skeletal system [1,4,9,[16][17][18], but knowledge of the value of RT in GSS is limited to several case reports and studies including a small number of patients. The endothelial cells of the abnormal vessels and proliferating capillaries are assumed to be the radiobiological target [3,13].…”