Radiothérapie hypofractionnée : quelles sont les règles à suivre ?

Supiot, S.; Clément-Colmou, K.; Pâris, François; Corre, Isabelle; Chiavassa, S.; Delpon, G.

doi:10.1016/j.canrad.2015.05.007

Cited by 5 publications

(1 citation statement)

References 27 publications

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“…Recently radiotherapy protocols combining high dosed sessions over a shorter total treatment duration have emerged and are called high dose hypofractionated radiotherapy (H-SRT). Stereotactic irradiation techniques allow better targeting of the tumor, thus making it possible to administer higher doses of ionizing radiation [5]. Preclinical data suggest that high doses per fraction generate a superior immunological response, responsible for an abscopal effect [6].…”

Section: Introductionmentioning

confidence: 99%

Combination of High Dose Hypofractionated Radiotherapy with Anti-PD1 Single Dose Immunotherapy Leads to a Th1 Immune Activation Resulting in a Complete Clinical Response in a Melanoma Patient

Milhem

Moralès

Ingelaere

et al. 2020

IJMS

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The development of immunotherapy has recently modified the anti-tumor therapeutic arsenal; particularly, immune checkpoint inhibitors have led to a significant increase in overall survival. The current challenge is now to select good responder patients by identifying early biomarkers to propose therapeutic combinations that potentiate the efficacy of the therapy. Here we report the case of a 60-year-old man with superficial melanoma treated with high-dose hypo fractionated radiotherapy (H-SRT) combined with a single dose of anti-PD1 immunotherapy (Nivolumab) for a metastatic lymph node recurrence due to cancer progression. In this study, we present the results obtained regarding the activation of the Th1 immune response after H-SRT treatment followed by anti PD-1 therapeutic protocol. These results were correlated with clinical data to identify potential immunological biomarkers of treatment efficacy. This exceptional case report shows that a combination of H-SRT with a single dose of anti-PD1 immunotherapy may allow a better activation of the immune response in favor of a complete clinical response.

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Section: Introductionmentioning

confidence: 99%