Radiotherapeutic Principles of Hematopoietic Cell Transplantation

Wong, Jeffrey Y.C.; Schultheiss, Timothy E.

doi:10.1002/9781118416426.ch22

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Toxicity and Follow-up1

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2018

2023

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Cited by 2 publications

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“…Even when TBI is fractionated and given concurrently with chemotherapy, pneumonitis occurs in about 25% of patients, although fractionation clearly reduces the risk of fatal events. Other acute toxic effects of TBI include parotitis (generally occurring on the second day of treatment) (34,35), nausea and vomiting (which can be prevented with modern anti-emetic agents), dry mouth and mucositis (which typically appear 5-20 days after TBI), diarrhea, fatigue, decreased appetite, erythema, esophagitis, and alopecia (36). Single-dose nonmyeloablative TBI (2 Gy) seems to not be associated with significant acute side effects and is well tolerated (37).…”

Section: Toxicity and Follow-upmentioning

confidence: 99%

Total Body Irradiation: Guidelines from the International Lymphoma Radiation Oncology Group (ILROG)

Wong

Filippi

Dabaja

et al. 2018

International Journal of Radiation Oncology*Biology*Physics

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152

173

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Total body irradiation (TBI) remains an effective myeloablative treatment in regimens used for preparation and conditioning before allogeneic stem cell transplantation for leukemia. The regimens used vary across institutions in terms of dose, dose rate, fractionation, and technique. The objective of this document is to provide comprehensive guidelines for the current practice of delivering total body irradiation.

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Section: Toxicity and Follow-upmentioning

confidence: 99%