Radiotherapeutic alternatives to standard management of adenocarcinoma of the endometrium

Andersen, Willie A.; Peters, William A.; Fechner, Robert E.; Morley, George W.; Thornton, W.Norman

doi:10.1016/0090-8258(83)90166-x

Cited by 20 publications

(3 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite this recommendation none of these authors reported a better disease specific survival in patients who were treated with additional external radiotherapy. More recently numerous authors have suggested that external radiation therapy does not contribute to survival and increase complications (11,17). It is pointed out that our good results are achieved with intracavitary brachytherapy alone.…”

Section: Discussionmentioning

confidence: 79%

See 1 more Smart Citation

Treatment of endometrial carcinoma with high‐dose‐rate brachytherapy alone in medically inoperable stage I patients

Kucera¹,

Knocke

Kucera³

et al. 1998

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 79%

“…Radiation therapy has proved effective in the treatment of medically inoperable endometrial carcinoma (10). A 5-year overall survival is quoted to be 41-73% for radiation therapy alone (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) and 80-94% for surgery (23). Disease specific survival has been reported to be 64-88% (3,10,15,17,20,24).…”

Section: Discussionmentioning

confidence: 99%

Treatment of endometrial carcinoma with high‐dose‐rate brachytherapy alone in medically inoperable stage I patients

Kucera¹,

Knocke

Kucera³

et al. 1998

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

show abstract

“…Prior studies have reported that a combination of external radiation therapy followed by intracavitary application has the greatest survival for endometrial carcinoma (13,21,23,26). More recently numerous authors have suggested that external radiation therapy does not contribute to survival and increase complications (11,17). Despite this recommendation none of these authors reported a better disease specific survival in patients who were treated with additional external radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

Treatment of endometrial carcinoma with high-dose-rate brachytherapy alone in medically inoperable stage I patients

Kucera¹,

Knocke²,

Kucera³

et al. 1998

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

show abstract

Endometrial carcinoma: Influence of prognostic factors on radiation management

Rotman¹,

Aziz²,

Halpern³

et al. 1993

Cancer

View full text Add to dashboard Cite

The earliest intracavitary radium treatment for uterine cancer was reported in 1908. Refinements reported during the next 20 years, using an intrauterine tube and colpostats or radium capsules, established a treatment philosophy of preoperatively irradiating uterine and parauterine tissues. Thus, preoperative intracavitary irradiation became entrenched as therapy for all endometrial cancers for the better part of four decades. In the 1950s and 1960s, the ability of external irradiation to eradicate cancer in regional lymphatic vessels prompted the use of pelvic field irradiation in Stage I1 and I11 and recurrent disease. The results of surgical exploratory studies in the 1970s established more refined criteria for preoperative or postoperative external pelvic irradiation in highgrade infiltrating Stage I cancers. In the 1980% it became apparent that, for tumors with lymphovascular invasion, clear cell, and serous papillary histologic types, the disease spread to the upper abdomen and the paraaortic nodes might benefit from extended field and/or whole abdominal irradiation, with or without systemic bolus or concomitant continuous-infusion chemotherapy. In the 1980s, a subset of patients was identified with high-grade lymphovascular invasion clear cell and papillary serous histologic types or with positive peritoneal cytologic findings who were at high risk of failing in the paraaortic nodes and/or the upper abdomen for whom extended field or whole abdominal irradiation have been advocated. Given the fraction and dose limitation for a large abdominal field, the addition of systemic concomitant bolus or continuous infusion of chemotherapy currently is proposed to improve the control of intraabdominal failure in these high-risk patients. Cancer 1993; 71:1471-9.

show abstract

Radiotherapeutic alternatives to standard management of adenocarcinoma of the endometrium

Abstract: Primary radiotherapy as an alternative management for adenocarcinoma of the endometrium was chosen for 117 patients treated at

Cited by 20 publications

References 16 publications

Treatment of endometrial carcinoma with high‐dose‐rate brachytherapy alone in medically inoperable stage I patients

Treatment of endometrial carcinoma with high‐dose‐rate brachytherapy alone in medically inoperable stage I patients

Treatment of endometrial carcinoma with high-dose-rate brachytherapy alone in medically inoperable stage I patients

Endometrial carcinoma: Influence of prognostic factors on radiation management

Contact Info

Product

Resources

About