Radiosurgery of Small Skull-Base Lesions

Ernst-Stecken, Antje; Lambrecht, Ulrike; Ganslandt, Oliver; Mueller, Reinhold; Fahlbusch, Rudolf; Sauer, Rolf; Grabenbauer, Gerhard G.

doi:10.1007/s00066-005-1371-1

Cited by 44 publications

(6 citation statements)

References 57 publications

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“…Dose calculation was done by pencil beam algorithm. The treatment delivery Novalis™/ExacTrac™ system (BrainLAB AG) has been described before [7]. ExacTrac™ is intended to place patients at the isocenter of a linear accelerator.…”

Section: Methodsmentioning

confidence: 99%

Hypofraktionierte stereotaktische Radiotherapie primärer und sekundärer Lungentumoren. Präliminäre Ergebnisse einer Phase-I/II-Studie

et al. 2006

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Purpose:To evaluate the feasibility, efficacy, and side effects of dose escalation in hypofractionated stereotactic radiotherapy (hfSRT) for intrapulmonary tumors with the Novalis™ system (BrainLAB AG, Heimstetten, Germany).Patients and Methods:From 07/2003 to 01/2005, 21 patients/39 tumors were treated with 5 × 7 Gy (n = 21; total dose 35 Gy) or 5 × 8 Gy (n = 18; total dose 40 Gy). There were three cases of primary lung cancer, the remainder were metastases. Median gross tumor volume (GTV) and planning target volume (PTV) were 2.89 cm3 (range, 0.15–67.94 cm3) and 25.75 cm3 (range, 7.18–124.04 cm3), respectively.Results:Rates of complete remission, partial remission, no change, and progressive disease were 51%, 33%, 3%, and 13%, respectively. No grade 4 toxicity occurred, nearly all patients had grade 1 initially. One grade 3 toxicity, i.e., dyspnea, was documented for a period of 6 months after therapy. Radiosurgery quality assurance guidelines could be met.Conclusion:hfSRT of primary and secondary lung tumors using a schedule of five fractions at 7–8 Gy each was well tolerated. Further dose escalation is planned.

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Section: Methodsmentioning

confidence: 99%

Hypofraktionierte stereotaktische Radiotherapie primärer und sekundärer Lungentumoren. Präliminäre Ergebnisse einer Phase-I/II-Studie

et al. 2006

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“…In the past, conventional Intensity Modulated Radiotherapy (IMRT) was tested to resolve the difficulties in covering of noncircular or ellipsoid targets with mixed success but without solving all described problems as well in fractionated as in single fraction irradiation procedures [3-7]. …”

Section: Introductionmentioning

confidence: 99%

Single fraction radiosurgery using Rapid Arc for treatment of intracranial targets

et al. 2010

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BackgroundStereotactic-Radio-Surgery (SRS) using Conformal-Arc-Therapy (CAT) is a well established irradiation technique for treatment of intracranial targets. Although small safety margins are required because of very high accuracy of patient positioning and exact online localisation, there are still disadvantages like long treatment time, high number of monitor units (MU) and covering of noncircular targets. This planning study analysed whether Rapid Arc (RA) with stereotactic localisation for single-fraction SRS can solve these problems.MethodsTen consecutive patients were treated with Linac-based SRS. Eight patients had one or more brain metastases. The other patients presented a symptomatic vestibularis schwannoma and an atypic meningeoma. For all patients, two plans (CAT/RA) were calculated and analysed.ResultsConformity was higher for RA with additional larger low-dose areas. Furthermore, RA reduced the number of MU and the treatment time for all patients. Dose to organs at risk were equal or slightly higher using RA in comparison to CAT.ConclusionsRA provides a new alternative for single-fraction SRS irradiation combining advantages of short treatment time with lower number of MU and better conformity in addition to accuracy of stereotactic localisation in selected cases with uncomplicated clinical realization.

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“…Beam shaping results in better comformality than circular cones for irregularly shaped target volumes [2,11,12,22]. Commercially available mini-multileaf collimators (MLC) with 2-5 mm leaf widths are regarded as state of the art devices for producing irregular shaped radiation fields [4,5,9,12]. At Ghent University Hospital, a long experience exists with the Pinnacle ® collapsed cone dose engine for precise computation of dose delivered by small beam segments.…”

Section: Introductionmentioning

confidence: 99%

Measurement Techniques, Modeling Strategies and Pitfalls to Avoid when Implementing a Mini MLC in a Non Dedicated Planning System*

Pittomvils

Coghe²,

Gersem³

et al. 2007

Strahlenther Onkol

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Radiosurgery of Small Skull-Base Lesions

Cited by 44 publications

References 57 publications

Hypofraktionierte stereotaktische Radiotherapie primärer und sekundärer Lungentumoren. Präliminäre Ergebnisse einer Phase-I/II-Studie

Hypofraktionierte stereotaktische Radiotherapie primärer und sekundärer Lungentumoren. Präliminäre Ergebnisse einer Phase-I/II-Studie

Single fraction radiosurgery using Rapid Arc for treatment of intracranial targets

Measurement Techniques, Modeling Strategies and Pitfalls to Avoid when Implementing a Mini MLC in a Non Dedicated Planning System*

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